Results 201 to 210 of about 60,949 (235)

Activin, Activin-Binding Protein (Follistatin) and Activin Receptor

1993
The principal regulators of the pituitary gonadotropins LH and FSH in mammals are the gonadotropin-releasing hormone (GnRH) from the hypothalamus and the gonadal steroids.
Hiromu Sugino, Takanori Nakamura, Kishiko Sugino, Koiti Titani   +3 more
openaire   +1 more source

Activin A and Activin Receptors in Thyroid Cancer

Thyroid, 2001
Proliferation is controlled by a network of mitogenic and growth inhibitory factors. Transforming growth factor-beta1 (TGF-beta1) and activin A are the most important growth inhibitors of benign follicular epithelial cells of the human thyroid. The effects of these substances on malignant primary thyrocytes are not known.
K M, Schulte, C, Jonas, R, Krebs, H D, Röher   +3 more
openaire   +2 more sources

Bovine preantral follicles and activin: Immunohistochemistry for activin and activin receptor and the effect of bovine activin a in vitro

Theriogenology, 1997
Activin was originally isolated from follicular fluid as a factor stimulating FSH from the pituitary. Recent studies also suggest a local role for activin in the development of preantral and early antral follicles. In the present study, activin and activin receptor immunoreactivity are shown in oocyte and granulosa cells of bovine preantral follicles ...
S C, Hulshof, J R, Figueiredo, J F, Beckers, M M, Bevers, H, Vanderstichele, R, van den Hurk   +5 more
openaire   +2 more sources

Inhibins and Activins

1988
Publisher Summary This chapter discusses the isolation, structure, characterization, and biosynthesis of inhibins and activins. The two pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) which regulate the development and maturation of the gonad, are identified.
N, Ling, N, Ueno, S Y, Ying, F, Esch, S, Shimasaki, M, Hotta, P, Cuevas, R, Guillemin   +7 more
openaire   +2 more sources

Activin Receptor Inhibitors—Dalantercept

Current Oncology Reports, 2015
Development of anti-angiogenic therapy including the vascular endothelial growth factor (VEGF) antibodies and VEGF-tyrosine kinase receptors has been a major landmark in cancer therapy leading improvement in survival in several cancers. While anti-angiogenic therapy is effective in some settings, resistance often develops owing to evasive, alternative ...
Shilpa, Gupta, David, Gill, Sumanta K, Pal, Neeraj, Agarwal   +3 more
openaire   +2 more sources

Activin Signal Transduction Pathways

Trends in Endocrinology & Metabolism, 2000
Many of the signal transduction pathways required for mammalian endocrine cell function are conserved from flies and worms. These model organisms permitted the illumination of the biological properties of ligands and provided systems in which cellular coactivating molecules could be identified rapidly.
S A, Pangas, T K, Woodruff
openaire   +2 more sources

Activins and activin antagonists in the prostate and prostate cancer

Molecular and Cellular Endocrinology, 2012
Activins are members of the TGF-β super-family. There are 4 mammalian activin subunits (β(A), β(B), β(C) and β(E)) that combine to form functional proteins. The role of activin A (β(A)β(A)) is well characterized and known to be a potent growth and differentiation factor.
Elspeth, Gold, Gail, Risbridger
openaire   +2 more sources

Follistatin/activin-binding protein

Trends in Endocrinology & Metabolism, 1992
Follistatin, or follicle-stimulating hormone (FSH) suppressing protein, is a protein isolated from side fractions in the purification of inhibin and activin, which shares with inhibin the property of suppressing the secretion of FSH from the pituitary gonadotroph. This protein is structurally distinct from inhibin.
openaire   +2 more sources

Activin in Glucose Metabolism

2011
Activins, members of the TGF-β family, are multifunctional growth and differentiation factors. Activins regulate glucose/energy metabolism by promoting the differentiation of insulin-producing and -responsive cells, and regulating function of the differentiated cells.
Osamu, Hashimoto, Masayuki, Funaba
openaire   +2 more sources