Results 31 to 40 of about 73,976 (284)

Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. [PDF]

, 2015
BackgroundUnderstanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.
Akagi, Naomi, Bauer, Jessica, Carroll, Timothy, Eckmann, Lars, Grippo, Paul J, Jung, Barbara, Ozden, Ozkan, Principe, Daniel R, Spehlmann, Martina E, Staudacher, Jonas J   +9 more
core   +2 more sources

Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells [PDF]

, 2012
Peer reviewedPublisher ...
A Kubo, AK Teo, C. H.-H. Cho, D Zhang, E Kroon, E Wandzioch, F. M. Docherty, H Li, H. M. Docherty, IG Brons, J Ameri, J Cai, J Jonsson, JA Thomson, JF Habener, JK Mfopou, JM Wells, JR Spence, K Takahashi, K. Docherty, KA D’Amour, KA Harrison, KS Zaret, L Vallier, L Vallier, L. Vallier, M Inamura, M Polak, M. Joåo Lima, M. W. B. Trotter, MC Nostro, MF Offield, N. R.-F. Hannan, OG Kelly, R Bort, R Maehr, RI Sherwood, S Brown, ST Rashid, T Touboul, V Ramos-Mejia, W Jiang, Y Kunisada   +42 more
core   +2 more sources

Activins and Activin Receptors in Cell Growth

Experimental Biology and Medicine, 1997
Activin and inhibin, members of transforming growth factor-beta (TGFbeta) superfamily, have diverse and widespread effects within living organisms at many stages during growth and development. From the initial isolation of these growth factors based on their effects of FSH secretion, the study of these factors, as well as of the activin-binding protein
S Y, Ying, Z, Zhang, B, Furst, Y, Batres, G, Huang, G, Li   +5 more
openaire   +2 more sources

Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds

Nature Communications, 2020
Matrix deposition is essential for wound repair, but when excessive, leads to hypertrophic scars and fibrosis. The factors that control matrix deposition in skin wounds have only partially been identified and the consequences of matrix alterations for ...
Mateusz S. Wietecha, M. Pensalfini, M. Cangkrama, Bettina Müller, Juyoung Jin, J. Brinckmann, E. Mazza, S. Werner   +7 more
semanticscholar   +1 more source

Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. [PDF]

, 2017
BackgroundProper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development, leading to ...
Brayman, Melissa J, Hoffmann, Hanne M, Iyer, Anita K, Mellon, Pamela L, Ngo, Cindy, Sunshine, Mary Jean, Xie, Huimin   +6 more
core   +3 more sources

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

eLife, 2020
Activin A functions in BMP signaling in two ways: it either engages ACVR1B to activate Smad2/3 signaling or binds ACVR1 to form a non-signaling complex (NSC).
S. Aykul, R. A. Corpina, Erich J. Goebel, C. Cunanan, Alexandra Dimitriou, Hyonjong Kim, Qian Zhang, A. Rafique, Raymond Leidich, Xin Wang, J. McClain, Johanna Jimenez, Kalyan C. Nannuru, Nyanza J. Rothman, John B. Lees-Shepard, E. Martinez-Hackert, A. Murphy, T. Thompson, A. Economides, V. Idone   +19 more
semanticscholar   +1 more source

A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming

EMBO Molecular Medicine, 2020
Cancer‐associated fibroblasts (CAFs) are key regulators of tumorigenesis and promising targets for next‐generation therapies. We discovered that cancer cell‐derived activin A reprograms fibroblasts into pro‐tumorigenic CAFs.
M. Cangkrama, Mateusz S. Wietecha, Nicolas Mathis, Rin Okumura, L. Ferrarese, D. Al-Nuaimi, M. Antsiferova, R. Dummer, M. Innocenti, S. Werner   +9 more
semanticscholar   +1 more source

Activin A in Mammalian Physiology.

Physiological Reviews, 2019
Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins.
E. Bloise, P. Ciarmela, C. Dela Cruz, S. Luisi, F. Petraglia, F. Reis   +5 more
semanticscholar   +1 more source

Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector

Frontiers in Cellular and Infection Microbiology, 2019
Despite the increasing number of studies concerning insect immunity, Lutzomyia longipalpis immune responses in the presence of Leishmania infantum chagasi infection has not been widely investigated. The few available studies analyzed the role of the Toll
Tatiana Di-Blasi, Erich Loza Telleria, Erich Loza Telleria, Christiane Marques, Rodrigo de Macedo Couto, Monique da Silva-Neves, Magdalena Jancarova, Petr Volf, Antonio Jorge Tempone, Yara Maria Traub-Csekö   +9 more
doaj   +1 more source

Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure

Frontiers in Endocrinology, 2023
Correct fetal testis development underpins adult male fertility, and TGFβ superfamily ligands control key aspects of this process. Transcripts encoding one such ligand, activin A, are upregulated in testes after sex determination and remain high until ...
Penny A. F. Whiley, Penny A. F. Whiley, Michael C. M. Luu, Liza O’Donnell, David J. Handelsman, Kate L. Loveland, Kate L. Loveland   +6 more
doaj   +1 more source