Results 131 to 140 of about 59,022 (255)
Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro
JOR SPINE, Volume 9, Issue 2, June 2026.Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis +4 more
wiley +1 more source
Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis [PDF]
, 1993 To contribute to an understanding of the roles and mechanisms of action of Wnts in early vertebrate development, we have characterized the normal expression of Xenopus laevis Wnt-5A, and investigated the consequences of misexpression of this putative ...
Campbell, Robert M. +5 more
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The FASEB Journal, Volume 40, Issue 7, 15 April 2026.The helminth TGF‐β mimic TGM4 activates SMAD signaling in macrophages and T cells through canonical TGF‐β receptors and the CD44 co‐receptor, through Domains 1–5 (D1‐5). In fibroblasts, which express lower levels of CD44, TGM4 binds but does not transduce a signal; furthermore, it inhibits activation by agonist ligands such as TGF‐β itself, in a manner
Kyle T. Cunningham +15 more
wiley +1 more source
Scientific Reports, 2017 Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed in isolation ...
Jonas J. Staudacher +11 more
doaj +1 more source
Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development
Advanced Science, Volume 13, Issue 19, 2 April 2026.This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen +11 more
wiley +1 more source
Brain and Behavior, Volume 16, Issue 4, April 2026.Can invasive suckermouth catfish, Hypostomus plecostomus, be used as fishmeal? A potential solution to eradicate it from the Buriganga River, Bangladesh ABSTRACT Background and objective: Sarcoidosis, characterized by granulomatous inflammation across multiple systems, has an unclear connection with ischemic stroke and shared molecular pathways.
Zihong Bai +7 more
wiley +1 more source
Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages
EMBO Molecular Medicine, 2016 Activin has emerged as an important player in different types of cancer, but the underlying mechanisms are largely unknown. We show here that activin overexpression is an early event in murine and human skin tumorigenesis. This is functionally important,
Maria Antsiferova +10 more
doaj +1 more source
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Local complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Hui Zhang +9 more
wiley +1 more source
The Importance of Liver‐Lung Communication in Pulmonary Vascular Diseases
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Schematic depicting the key drivers of liver‐lung communication in pulmonary vascular diseases, including hepatic dysfunction, portosystemic shunting, and gut microbial dysbiosis, which together drive pulmonary vascular remodeling. ABSTRACT In normal health, the liver and lungs enjoy a close anatomic, physiologic, and functional relationship.
Navneet Singh +8 more
wiley +1 more source
Activin A: its role and involvement in inflammatory diseases [PDF]
, 2015 Activin proteins are members of the transforming growth factor-β family. Activin A is involved in several biological responses including wound repair, cell death, proliferation and differentiation of many cell types.
Basir, Rusliza +4 more
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