Results 81 to 90 of about 59,022 (255)

Activin C Antagonizes Activin A in Vitro and Overexpression Leads to Pathologies in Vivo [PDF]

The American Journal of Pathology, 2009
Activin A is a potent growth and differentiation factor whose synthesis and bioactivity are tightly regulated. Both follistatin binding and inhibin subunit heterodimerization block access to the activin receptor and/or receptor activation. We postulated that the activin-beta(C) subunit provides another mechanism regulating activin bioactivity.
Elspeth, Gold, Niti, Jetly, Moira K, O'Bryan, Sarah, Meachem, Deepa, Srinivasan, Supreeti, Behuria, L Gabriel, Sanchez-Partida, Teresa, Woodruff, Shelley, Hedwards, Hong, Wang, Helen, McDougall, Victoria, Casey, Birunthi, Niranjan, Shane, Patella, Gail, Risbridger   +14 more
openaire   +2 more sources

Differentiation of definitive endoderm from human induced pluripotent stem cells on hMSCs feeder in a defined medium [PDF]

, 2016
Background: The Definitive Endoderm (DE) differentiation using the undefined media and non-human feeders can cause contaminations in the generated cells for therapeutic applications.
Geramizadeh, B., Hosseinkhani, S., Jaafarpour, Z., Karimi, M.H., Mobarra, N., Soleimani, M., Yaghmaei, P.   +6 more
core  

Amniotic fluid embolism pathophysiology suggests the new diagnostic armamentarium: β-tryptase and complement fractions C3-C4 are the indispensable working tools [PDF]

, 2015
Amniotic fluid embolism (AFE) is an uncommon obstetric condition involving pregnant women during labor or in the initial stages after delivery. Its incidence is estimated to be around 5.5 cases per 100,000 deliveries.
Busardo', FRANCESCO PAOLO, Fineschi, Vittorio, Frati, Paola, Zaami, Simona   +3 more
core   +2 more sources

Activin Regulates  A-Subunit and Activin Receptor Messenger Ribonucleic Acid and Cellular Proliferation in Activin-Responsive Testicular Tumor Cells [PDF]

Endocrinology, 1998
Activin, a member of the transforming growth factor-beta superfamily of growth and differentiation factors, has a number of actions in embryonic as well as adult tissues. These actions are mediated via a family of receptors containing two subtypes and at least two members of each subtype.
Di Simone, Nicoletta, Hall Ha, Welt C, Schneyer Al   +3 more
openaire   +2 more sources

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Parkinson's Disease Patient‐Specific Striatum Organoids Show Hallmarks of Increased Inflammation

Movement Disorders, EarlyView.
Abstract Background Dopaminergic neurons from the substantia nigra pars compacta project their axons into the dorsal striatum, forming the nigrostriatal pathway. In Parkinson's disease (PD), dopaminergic terminals degenerate in the striatum, leading to dopamine depletion, which in turn causes alterations in the basal ganglia circuits that are essential
Kyriaki Barmpa, Claudia Saraiva, Alise Zagare, Mona Tuzza, Joseph Longworth, Elisa Zuccoli, Katrin Hufnagel, Florian Skwirblies, Ronny Schmidt, Dirk Brenner, Christoph Schröder, Jens C. Schwamborn   +11 more
wiley   +1 more source

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]

, 2018
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena, Danilova, Nadia, Lin, Shuo, Sakamoto, Kathleen M, Wilkes, Mark, Youn, Min-Young   +5 more
core   +2 more sources

Bright Ferritin for Non‐Invasive MRI Monitoring of the Fate of Transplanted hPSC‐Cardiomyocytes in the Infarcted Rat Heart

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To demonstrate that a recently reported bright ferritin magnetic resonance imaging (MRI) platform can track transplanted human pluripotent stem cell (hPSC)‐derived cardiomyocytes (hPSC‐CMs) longitudinally and on‐demand in the rat heart.
Keyu Zhuang, Faisal J. Alibhai, Beiping Qiang, Rocco Romagnuolo, Kyle D. W. Vollett, Bradley K. C. Freeman, M. Juliana Gomez‐Garcia, Tamilla Sadikov Valdman, Tameshwar Ganesh, Yu‐Qing Zhou, Hai‐Ying Mary Cheng, Michael A. Laflamme, Hai‐Ling Margaret Cheng   +12 more
wiley   +1 more source

Expression of SMADs in orthotopic human endometrium, ovarian endometriosis, and endometriotic lesions in a murine model

Endocrine Journal
Activin A promotes the development of endometriotic lesions in a murine model of endometriosis, and the immunohistochemical localization of phosphorylated suppressor of mothers against decapentaplegic homolog 2/3 (pSMAD2/3) complex in endometriotic ...
Yuri Kadota, Takeshi Kato, Kana Kasai, Takako Kawakita, Misaki Murayama, Akari Shinya, Hikari Sasada, Sachiko Katayama, Mari Nii, Shota Yamamoto, Hiroki Noguchi, Kou Tamura, Hidenori Aoki, Miyu Taniguchi, Tomotaka Nakagawa, Takashi Kaji, Masato Nishimura, Riyo Kinouchi, Kanako Yoshida, Takeshi Iwasa   +19 more
doaj   +1 more source

Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor (TGF ) signaling is essential for testicular aging and regulating testis size [PDF]

, 2013
Follistatin-like 3 (FSTL3) is a glycoprotein that binds and inhibits the action of TGFβ ligands such as activin. The roles played by FSTL3 and activin signaling in organ development and homeostasis are not fully understood.
Abir Mukherjee, Alan L. Schneyer, Andrew A. Pitsillides, Archambeault, Baker, Bakker, Bartholin, Bastow, Besset, Brehm, Chan, Cohen, Cooke, Cooke, Cooke, Coultas, Coussens, Dierich, Do, Fujita, Gill, Hardwick, Itman, Jan Seebacher, Johnston, Judit Villen, Karla J. Oldknow, Kato, Kato, Kooy, Kumar, Lee, Matzuk, Mukherjee, Nef, Noriega, Parvinen, Peter J. O'Shaughnessy, Salisbury, Shang, Sharpe, Sidis, Slegtenhorst-Eegdeman, St-Pierre, Steeno, Steven P. Gygi, Tanimoto, Tapasree Goswami, Tolonen, Tsuchida, Turek, Wilhelm, Wreford, Xia, Yang   +54 more
core   +1 more source