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Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, Volume 59, Issue 4, April 2026.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding +8 more
wiley +1 more source

Activins Family

, 2019
Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Identified in 1986, activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle.
openaire +1 more source

Transcriptome Comparison Between the Cultured and In Vivo Chick Primordial Germ Cells by SMART‐Seq‐Based Single‐Cell RNA Sequencing

Development, Growth &Differentiation, Volume 68, Issue 3, April 2026.
Cultivation of PGCs triggers a transition from MYC‐ to MYCN‐driven transcriptional regulation. ABSTRACT Primordial germ cells (PGCs), the precursors of the germline, have unique cellular characteristics to undergo long‐distance migration to the embryonic gonads and have the potential to differentiate into somatic cells. Among the animal models studying
Yoshiki Hayashi +7 more
wiley +1 more source

Understanding Impact of Anti‐Obesity Medications on Skeletal Muscle Mass Change Is Confounded by Measurement Methods

Obesity Reviews, Volume 27, Issue 4, April 2026.
ABSTRACT Anti‐obesity medications promote greater degrees of weight loss than lifestyle interventions alone. There is an important need to understand whether loss of skeletal muscle during pharmacologically induced weight loss is clinically significant due to its essential role in health and disease.
Arden McMath, Dympna Gallagher
wiley +1 more source

Revealing Sexual Dimorphism in Prolactin Regulation From Early Postnatal Development to Adulthood in Murine Models. [PDF]