Results 141 to 150 of about 20,228 (237)
Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.Abstract The oral, small molecule inhibitor of activin receptor‐like kinase‐2, zilurgisertib (INCB000928), is under evaluation in fibrodysplasia ossificans progressiva. Cardiac safety was assessed using electrocardiogram (ECG) parameters and a plasma concentration‐heart rate‐corrected QT (C‐QTc) interval analysis of pooled data from single ascending ...
Yan‐ou Yang +5 more
wiley +1 more source
Melanoma cells secrete follistatin, an antagonist of activin-mediated growth inhibition [PDF]
, 2004 Bracke, Marc +5 more
core +2 more sources
The Vascular‐Immune Cells Crosstalk and Microenvironment in Pulmonary Hypertension
Comprehensive Physiology, Volume 16, Issue 1, February 2026.This review synthesizes current evidence showing how vascular–immune cell crosstalk and microenvironmental cues shape pulmonary vascular remodeling in pulmonary hypertension. We provide an integrative perspective that positions disrupted cellular communication as a central driver of disease progression and a promising source of future therapeutic ...
Lola Navarro‐Llinares +3 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.Pan‐cancer analysis reveals an inflammatory phenotype remodeling of tissue‐resident macrophages (iTRM) in the tumor microenvironment, which is associated with immunosuppression. Tissue‐resident macrophages and monocyte‐derived macrophages exhibit convergent differentiation toward a similar inflammatory phenotype. iTRM‐enriched ecosystems are associated
Weikai Wang +19 more
wiley +1 more source
Effects of recombinant activins on steroidogenesis in human granulosa-lutein cells.
Journal of Clinical Endocrinology and Metabolism, 2014 Hsun‐Ming Chang +4 more
semanticscholar +1 more source
Glia, Volume 74, Issue 2, February 2026.Acute intermittent hypoxia is a novel, noninvasive therapy that shows promising and similar beneficial repair and remyelination following demyelination in male experimental autoimmune encephalomyelitis, as was previously shown in female mice. ABSTRACT Multiple sclerosis (MS) affects women more frequently than men, but the disease progresses more ...
Nataliya Tokarska +6 more
wiley +1 more source
MedComm, Volume 7, Issue 2, February 2026.Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao +8 more
wiley +1 more source
Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen +5 more
wiley +1 more source
Zinc Deficiency Disrupts Germ Cell Nest Breakdown During In Vitro Ovary Culture
Molecular Reproduction and Development, Volume 93, Issue 2, February 2026.ABSTRACT In mammals, the size of the non‐renewable primordial follicle pool is established before or soon after birth. Primordial follicles, each composed of a single oocyte surrounded by somatic cells, are the only source of gametes during the entire reproductive lifespan of the female.
James M. Hester +3 more
wiley +1 more source