Results 111 to 120 of about 726,631 (184)

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

open access: yesBritish Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher   +6 more
wiley   +1 more source

Robust gap repair in the contractile ring ensures timely completion of cytokinesis [PDF]

open access: yes, 2016
Cytokinesis in animal cells requires the constriction of an actomyosin contractile ring, whose architecture and mechanism remain poorly understood. We use laser microsurgery to explore the biophysical properties of constricting rings in Caenorhabditis ...
Daniel S. Osório   +17 more
core   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

open access: yesBritish Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang   +5 more
wiley   +1 more source

A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans

open access: yeseLife, 2018
To ensure timely cytokinesis, the equatorial actomyosin contractile ring constricts at a relatively constant rate despite its progressively decreasing size. Thus, the per-unit-length constriction rate increases as ring perimeter decreases.
Renat N Khaliullin   +6 more
doaj   +1 more source

A Conceptual Framework for Understanding Intelligent Behavior in Fungal Mycelia

open access: yesTopics in Cognitive Science, EarlyView.
Abstract Fungi exhibit remarkably complex behavior through their mycelial networks, which consist of thread‐like structures known as hyphae. Recent research on saprotrophic fungi has demonstrated that their mycelium behaves in ways that indicate memory, learning, decision‐making, and problem‐solving based on spatial pattern recognition—all of which are
Yu Fukasawa
wiley   +1 more source

The Tem1 Small GTPase Controls Actomyosin and Septin Dynamics during Cytokinesis [PDF]

open access: yes, 2001
Cytokinesis in budding yeast involves an actomyosin-based ring which assembles in a multistepped fashion during the cell cycle and constricts during cytokinesis.
Li, Rong   +4 more
core  

PP2A-Cdc55 phosphatase regulates actomyosin ring contraction and septum formation during cytokinesis. [PDF]

open access: yesCell Mol Life Sci, 2022
Moyano-Rodríguez Y   +5 more
europepmc   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Phosphorylation of the F-BAR protein Hof1 drives septin ring splitting in budding yeast

open access: yesNature Communications
A double septin ring accompanies cytokinesis in yeasts and mammalian cells. In budding yeast, reorganisation of the septin collar at the bud neck into a dynamic double ring is essential for actomyosin ring constriction and cytokinesis.
Maritzaida Varela Salgado   +8 more
doaj   +1 more source

Making the Final Cut — Mechanisms Mediating the Abscission Step of Cytokinesis

open access: yesThe Scientific World Journal, 2010
Cytokinesis is the final stage of mitotic cell division that results in a physical separation of two daughter cells. Cytokinesis begins in the early stages of anaphase after the positioning of the cleavage plane and after the chromosomes segregate.
John A. Schiel, Rytis Prekeris
doaj   +1 more source

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