Results 101 to 110 of about 7,599 (177)

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

The Mechanosensitive Pkd2 Channel Modulates the Recruitment of Myosin II and Actin to the Cytokinetic Contractile Ring

Journal of Fungi
Cytokinesis, the last step in cell division, separates daughter cells through mechanical force. This is often through the force produced by an actomyosin contractile ring.
Pritha Chowdhury, Debatrayee Sinha, Abhishek Poddar, Madhurya Chetluru, Qian Chen   +4 more
doaj   +1 more source

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression

The FEBS Journal, EarlyView.
Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre, Guila Dayan, Patricia Rousselle   +2 more
wiley   +1 more source

Two Septin complexes mediate actin dynamics during cell wound repair

Cell Reports
Summary: Cells have robust wound repair systems to prevent further damage or infection and to quickly restore cell cortex integrity when exposed to mechanical and chemical stress.
Viktor Stjepić, Mitsutoshi Nakamura, Justin Hui, Susan M. Parkhurst   +3 more
doaj   +1 more source

Cytokinesis: Myosin Spots the Ring

, 2002
Faithful actomyosin ring assembly is pivotal for successful cell division. The mechanisms by which the actomyosin ring is assembled at the correct time and place remain unclear.
McCollum, Dannel, Hou, Ming-Chin
core   +2 more sources

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Structure and constriction mechanism of the actomyosin ring [PDF]

, 2017
Cytokinesis is orchestrated by a contractile actomyosin ring, but its structure and mechanism remain elusive. We visualized the 3D structure of the ring in frozen‐hydrated dividing yeast cells by electron cryotomography (ECT).
Jensen, G. J., Nguyen, L. T.
core  

Recruitment of the mitotic exit network to yeast centrosomes couples septin displacement to actomyosin constriction

Nature Communications, 2018
The Mitotic Exit Network (MEN) promotes mitotic exit and cytokinesis but if and how MEN independently controls these two processes is unclear. Here, the authors report that MEN displaces septins from the cell division site to promote actomyosin ring ...
Davide Tamborrini, Maria Angeles Juanes, Sandy Ibanes, Giulia Rancati, Simonetta Piatti   +4 more
doaj   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Robust gap repair in the contractile ring ensures timely completion of cytokinesis [PDF]

, 2016
Cytokinesis in animal cells requires the constriction of an actomyosin contractile ring, whose architecture and mechanism remain poorly understood. We use laser microsurgery to explore the biophysical properties of constricting rings in Caenorhabditis ...
Daniel S. Osório, Ana Xavier Carvalho, Rubinstein, Boris, Gassmann, Reto, Pinto, Inês Mendes, Inês Mendes Pinto, Boris Rubinstein, Pereira, Antonio J, Telley, Ivo Andreas, Reto Gassmann, Osório, Daniel S, Antonio J. Pereira, Maiato, Helder, Helder Maiato, Ana M. Silva, Carvalho, Ana Xavier, Ivo Andreas Telley, Silva, Ana M   +17 more
core   +1 more source