Results 81 to 90 of about 726,631 (184)

Wrangling Actin Assemblies: Actin Ring Dynamics during Cell Wound Repair

Cells, 2022
To cope with continuous physiological and environmental stresses, cells of all sizes require an effective wound repair process to seal breaches to their cortex.
Justin Hui, Viktor Stjepić, Mitsutoshi Nakamura, Susan M. Parkhurst   +3 more
doaj   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Vrp1p Functions in Both Actomyosin Ring‐Dependent and Hof1p‐Dependent Pathways of Cytokinesis [PDF]

Traffic, 2001
Vrp1p/verprolin/End5p is a Saccharomyces cerevisiae proline‐rich protein, structurally and functionally related to human Wiskott–Aldrich syndrome protein‐interacting protein. Vrp1p is required for viability at 37°C, but not 24°C. Here, we show that loss of Vrp1p (vrp1Δ) leads to a 3–4‐fold delay in cytokinesis, wide bud necks, abnormal ...
S N, Naqvi, Q, Feng, V J, Boulton, R, Zahn, A L, Munn   +4 more
openaire   +2 more sources

Translational Macrophage Mechano‐Immunotherapy for Next‐Generation Implantable Biomaterials

Advanced NanoBiomed Research, EarlyView.
This review explores how macrophage mechanosensing drives inflammation, fibrosis and foreign body responses to implanted biomaterials. It examines emerging pharmacological strategies to modulate mechanotransduction, alongside biomaterial platforms for localised drug delivery, clinical translation, regulatory considerations and standardised testing ...
Xueying Xu, Ian L. Chin, Richard P. Tan
wiley   +1 more source

Bub2 regulation of cytokinesis and septation in budding yeast

BMC Cell Biology, 2009
Background The mitotic exit network (MEN) is required for events at the end of mitosis such as degradation of mitotic cyclins and cytokinesis. Bub2 and its binding partner Bfa1 act as a GTPase activating protein (GAP) to negatively regulate the MEN ...
Park Su Young, Cable Addie E, Blair Jessica, Stockstill Katherine E, Shannnon Katie B   +4 more
doaj   +1 more source

The Role of the Cell Integrity Pathway in Septum Assembly in Yeast

Journal of Fungi, 2021
Cytokinesis divides a mother cell into two daughter cells at the end of each cell cycle and proceeds via the assembly and constriction of a contractile actomyosin ring (CAR).
Cesar Roncero, Rubén Celador, Noelia Sánchez, Patricia García, Yolanda Sánchez   +4 more
doaj   +1 more source

Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation

BMEMat, EarlyView.
Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh, Varsha Sagar, Amal George Kurian, Shreyas Kumar Jain, Hye Sung Kim, Hae‐Won Kim   +5 more
wiley   +1 more source

Structure and constriction mechanism of the actomyosin ring

, 2017
Cytokinesis is orchestrated by a contractile actomyosin ring, but its structure and mechanism remain elusive. We visualized the 3D structure of the ring in frozen‐hydrated dividing yeast cells by electron cryotomography (ECT). Detailed arrangements of actin filaments within the ring and with respect to the membrane were seen for the first time ...
Nguyen, L. T., Jensen, G. J.
openaire   +2 more sources

UCS protein Rng3p is essential for myosin-II motor activity during cytokinesis in fission yeast. [PDF]

PLoS ONE, 2013
UCS proteins have been proposed to operate as co-chaperones that work with Hsp90 in the de novo folding of myosin motors. The fission yeast UCS protein Rng3p is essential for actomyosin ring assembly and cytokinesis.
Benjamin C Stark, Michael L James, Luther W Pollard, Vladimir Sirotkin, Matthew Lord   +4 more
doaj   +1 more source

Substrate stiffness regulates cell fate and its applications in the repair of motor system: From two dimensions to three dimensions

BMEMat, EarlyView.
Substrate stiffness with different dimensions (2D and 3D) exerts a regulatory role in cellular behaviors, thereby governing cell fate decisions. Biomaterials with tunable stiffness exhibit substantial functional potential for the repair and regeneration of the motor system.
Zhiyuan Lu, Renwang Sheng, Ludvig J. Backman, Chuanquan Liu, Danning Zheng, Wei Zhang, Jialin Chen   +6 more
wiley   +1 more source