Results 71 to 80 of about 6,880 (162)

Isolation of Cytokinetic Actomyosin Rings from Saccharomyces cerevisiae and Schizosaccharomyces pombe [PDF]

, 2016
Cytokinesis is the final stage of cell division, through which cellular constituents of mother cells are partitioned into two daughter cells resulting in the increase in cell number. In animal and fungal cells cytokinesis is mediated by an actomyosin contractile ring, which is attached to the overlying cell membrane.
Junqi, Huang, Mithilesh, Mishra, Saravanan, Palani, Ting Gang, Chew, Mohan K, Balasubramanian   +4 more
openaire   +2 more sources

Nonmedially assembled F-actin cables incorporate into the actomyosin ring in fission yeast [PDF]

Journal of Cell Biology, 2012
In many eukaryotes, cytokinesis requires the assembly and constriction of an actomyosin-based contractile ring. Despite the central role of this ring in cytokinesis, the mechanism of F-actin assembly and accumulation in the ring is not fully understood.
Huang, J., Huang, Y., Yu, H., Subramanian, D., Padmanabhan, A., Thadani, R., Tao, Y., Tang, X., Wedlich-Söldner, R., Balasubramanian, M.   +9 more
openaire   +3 more sources

Redefining the Role of Splenectomy in Scirrhous Gastric Cancer: Toward a Selective Multimodal Strategy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Scirrhous gastric cancer, characterized by diffuse infiltration and a high propensity for peritoneal dissemination, remains one of the most aggressive subtypes of gastric cancer. Despite a relatively high incidence of splenic hilar lymph node (No. 10) metastasis, the oncologic benefit of splenectomy remains controversial, while its association
Tsutomu Hayashi, Takaki Yoshikawa
wiley   +1 more source

The Multiple Roles of Cyk1p in the Assembly and Function of the Actomyosin Ring in Budding Yeast

Molecular Biology of the Cell, 1999
The budding yeast IQGAP-like protein Cyk1p/Iqg1p localizes to the mother-bud junction during anaphase and has been shown to be required for the completion of cytokinesis. In this study, video microscopy analysis of cells expressing green fluorescent protein-tagged Cyk1p/Iqg1p demonstrates that Cyk1p/Iqg1p is a dynamic component of the contractile ring ...
K B, Shannon, R, Li
openaire   +3 more sources

Vrp1p Functions in Both Actomyosin Ring‐Dependent and Hof1p‐Dependent Pathways of Cytokinesis [PDF]

Traffic, 2001
Vrp1p/verprolin/End5p is a Saccharomyces cerevisiae proline‐rich protein, structurally and functionally related to human Wiskott–Aldrich syndrome protein‐interacting protein. Vrp1p is required for viability at 37°C, but not 24°C. Here, we show that loss of Vrp1p (vrp1Δ) leads to a 3–4‐fold delay in cytokinesis, wide bud necks, abnormal ...
S N, Naqvi, Q, Feng, V J, Boulton, R, Zahn, A L, Munn   +4 more
openaire   +2 more sources

Wrangling Actin Assemblies: Actin Ring Dynamics during Cell Wound Repair

Cells, 2022
To cope with continuous physiological and environmental stresses, cells of all sizes require an effective wound repair process to seal breaches to their cortex.
Justin Hui, Viktor Stjepić, Mitsutoshi Nakamura, Susan M. Parkhurst   +3 more
doaj   +1 more source

Actomyosin rings constrain CD40 mobility to organize the dendritic cell immunological synapse. [PDF]

Cell Commun Signal
Abstract Background The interaction between dendritic cell CD40 and T cell CD40L is critical for dendritic cell licensing and the initiation of adaptive immunity. The spatial organization of CD40 on the dendritic cell surface is thought to dictate its signaling output, yet the underlying ...
Clamagirand CD, Mallet E, Nieves DJ, Ratswohl C, Owen DM, Rossy J.   +5 more
europepmc   +2 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Actin depolymerization drives actomyosin ring contraction during budding yeast cytokinesis. [PDF]

Dev Cell, 2012
Actin filaments and myosin II are evolutionarily conserved force-generating components of the contractile ring during cytokinesis. Here we show that in budding yeast, actin filament depolymerization plays a major role in actomyosin ring constriction.
Mendes Pinto I, Rubinstein B, Kucharavy A, Unruh JR, Li R.   +4 more
europepmc   +4 more sources

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome‐Wide Association Studies in Individuals With Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Joseph H. Breeyear, John S. House, Mark Kvale, Stella Nam, Farida S. Akhtari, Hetal S. Shah, Monique M. Hedderson, Kathleen M. Giacomini, Josyf C. Mychaleckyj, Alessandro Doria, Michael J. Wagner, Josephine H. Li, Sook Wah Yee, John B. Buse, Richard P. Woychik, Daniel M. Rotroff, Alison A. Motsinger‐Reif   +16 more
wiley   +1 more source