Results 1 to 10 of about 80,711 (299)
Journal of Biological Chemistry, 1969 Abstract Holo acyl carrier protein synthetase transfers 4'-phosphopantetheine from reduced coenzyme A to acyl carrier protein (ACP) apoprotein to form ACP holoprotein (holo-ACP). The specificity of this enzyme was tested by using apopeptides derived from ACP. The apopeptides were derived from holopeptides, those containing 4'-phosphopantetheine, by the
Michael D. Greenspan +2 more
+10 more sources
A broad inhibitor of acyl-acyl carrier protein synthetases. [PDF]
Biochem Biophys Rep, 2023 The acyl-acyl carrier protein synthetase enzyme enables some bacteria to scavenge free fatty acids from the environment for direct use in lipids. This fatty acid recycling pathway can help pathogens circumvent fatty acid synthase (FAS) inhibition with established antibiotics and those in clinical development.
Todorinova M, Beld J, Jaremko KL.
europepmc +4 more sources
Journal of Biological Chemistry, 1972 β-Ketoacyl-acyl carrier protein (ACP) synthetase catalyzes the chain elongation step of fatty acid biosynthesis, the condensation of fatty acyl-ACP with malonyl-ACP yielding β-ketoacyl-ACP, CO2, and ACP. This enzyme catalyzes two additional reactions, fatty acyl-CoA-ACP transacylation and the decarboxylation of malonyl-ACP to form acetyl-ACP and CO2 ...
Claire H. Birge, P. Roy Vagelos
+7 more sources
Acyl-Acyl Carrier Protein Desaturases and Plant Biotic Interactions. [PDF]
Cells, 2021 Interactions between land plants and other organisms such as pathogens, pollinators, or symbionts usually involve a variety of specialized effectors participating in complex cross-talks between organisms. Fatty acids and their lipid derivatives play important roles in these biological interactions. While the transcriptional regulation of genes encoding
Kazaz S, Miray R, Baud S.
europepmc +8 more sources
Journal of Biological Chemistry, 1966 Abstract A pantothenate-requiring auxotroph and a β-alanine-requiring auxotroph of Escherichia coli were grown in media supplemented with radioactive pantothenate or β-alanine, respectively. Analyses of extracts of these organisms showed that acyl carrier protein accounts for approximately 90% of the radioactivity associated with the protein fraction ...
Alfred W. Alberts, P. Roy Vagelos
openalex +3 more sources
Decoding allosteric regulation by the acyl carrier protein. [PDF]
Proc Natl Acad Sci U S A, 2021 SignificanceAcyl carrier proteins (ACPs) are involved in primary and secondary metabolic pathways, including the ubiquitous fatty acid biosynthesis, required for all domains of life. This single protein must deliver pathway intermediates to the appropriate enzyme, distinguishing between a myriad of possible intermediate-enzyme combinations.
Sztain T +8 more
europepmc +7 more sources
Stearoyl-Acyl Carrier Protein and Unusual Acyl-Acyl Carrier Protein Desaturase Activities Are Differentially Influenced by Ferredoxin [PDF]
Plant Physiology, 2000 Abstract Acyl-acyl carrier protein (ACP) desaturases function to position a single double bond into an acyl-ACP substrate and are best represented by the ubiquitous Δ9 18:0-ACP desaturase. Several variant acyl-ACP desaturases have also been identified from species that produce unusual monoenoic fatty acids.
David J. Schultz +2 more
openalex +5 more sources
Acyl Carrier Protein in Mycoplasmas [PDF]
Journal of Bacteriology, 1973 Acyl carrier protein (ACP) activity was determined by the malonyl-coenzyme A–CO 2 exchange reaction. It was highest in Acholeplasma laidlawii , lower in A. granularum , and lowest in A. axanthum . The sterol-requiring Mycoplasma
Shlomo Rottem +2 more
openaire +3 more sources
A Natural Plasmid Uniquely Encodes Two Biosynthetic Pathways Creating a Potent Anti-MRSA Antibiotic [PDF]
, 2011 Background Understanding how complex antibiotics are synthesised by their producer bacteria is essential for creation of new families of bioactive compounds. Thiomarinols, produced by marine bacteria belonging to the genus Pseudoalteromonas, are hybrids
Cox, Russell J. +11 more
core +13 more sources
Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]
, 2010 Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Alam, Mohammad T. +6 more
core +12 more sources