A broad inhibitor of acyl-acyl carrier protein synthetases [PDF]
Biochemistry and Biophysics Reports, 2023 The acyl-acyl carrier protein synthetase enzyme enables some bacteria to scavenge free fatty acids from the environment for direct use in lipids. This fatty acid recycling pathway can help pathogens circumvent fatty acid synthase (FAS) inhibition with ...
Magdalena Todorinova +2 more
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Acyl–Acyl Carrier Protein Desaturases and Plant Biotic Interactions [PDF]
Cells, 2021 Interactions between land plants and other organisms such as pathogens, pollinators, or symbionts usually involve a variety of specialized effectors participating in complex cross-talks between organisms.
Sami Kazaz +2 more
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Gating mechanism of elongating β-ketoacyl-ACP synthases [PDF]
Nature Communications, 2020 The formation of C-C bonds in fatty acid and polyketide biosynthesis depends on β-ketoacyl-acyl carrier protein (ACP) synthases (KSs). Here, the authors present structures of E.coli KSs bound to substrate mimetic bearing ACPs, providing insights into the
Jeffrey T. Mindrebo +9 more
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Acyl carrier protein promotes MukBEF action in Escherichia coli chromosome organization-segregation [PDF]
Nature Communications, 2021 E. coli MukBEF is an SMC complex that plays key roles in chromosome organization-segregation. Here the authors show that the interaction between MukBEF and the Acyl Carrier Protein (AcpP) is essential for MukBEF activity in vitro (ATPase) and in vivo.
Josh P. Prince +7 more
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Visualizing acyl carrier protein interactions within a crosslinked type I polyketide synthase [PDF]
Nature CommunicationsUsing a combination of dual covalent crosslinking and cryo-EM analyses, we elucidate the structure of mycocerosic acid synthase from Mycobacterium tuberculosis trapped in two distinct catalytic states during its iterative cycle.
Ziran Jiang +5 more
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Specialized acyl carrier protein used by serine palmitoyltransferase to synthesize sphingolipids in Rhodobacteria [PDF]
Frontiers in Microbiology, 2022 Serine palmitoyltransferase (SPT) catalyzes the first and committed step in sphingolipid biosynthesis condensating L-serine and acyl-CoA to form 3-oxo-sphinganine. Whenever the structural gene for SPT is present in genomes of Rhodobacteria (α-, β-, and γ-
Jonathan Padilla-Gómez +9 more
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An Acyl Carrier Protein Gene Affects Fatty Acid Synthesis and Growth of Hermetia illucens [PDF]
Insects, 2023 Acyl carrier protein (ACP) is an acyl carrier in fatty acid synthesis and is an important cofactor of fatty acid synthetase. Little is known about ACP in insects and how this protein may modulate the composition and storage of fatty acids.
Xiaoyan Peng +5 more
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Campylobacter jejuni resistance to human milk involves the acyl carrier protein AcpP [PDF]
mBioCampylobacter jejuni is a common foodborne pathogen worldwide that is associated with high rates of morbidity and mortality among infants in low- to middle-income countries (LMICs).
Bibi Zhou +14 more
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Determination of the Protein-Protein Interactions within Acyl Carrier Protein (MmcB)-Dependent Modifications in the Biosynthesis of Mitomycin [PDF]
Molecules, 2021 Mitomycin has a unique chemical structure and contains densely assembled functionalities with extraordinary antitumor activity. The previously proposed mitomycin C biosynthetic pathway has caused great attention to decipher the enzymatic mechanisms for ...
Dongjin Leng +7 more
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SCO6564, a novel 3-ketoacyl acyl carrier protein synthase III, contributes in fatty acid synthesis in Streptomyces coelicolor. [PDF]
PLoS ONEThe genus Streptomyces comprises gram-positive bacteria that produce large numbers of secondary metabolites, which have promising commercial applications and deserve extensive study.
Jian-Rong Ma +6 more
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