Results 1 to 10 of about 152,036 (336)
Acyl–Acyl Carrier Protein Desaturases and Plant Biotic Interactions [PDF]
Cells, 2021 Interactions between land plants and other organisms such as pathogens, pollinators, or symbionts usually involve a variety of specialized effectors participating in complex cross-talks between organisms.
Sami Kazaz +2 more
doaj +8 more sources
A broad inhibitor of acyl-acyl carrier protein synthetases [PDF]
Biochemistry and Biophysics Reports, 2023 The acyl-acyl carrier protein synthetase enzyme enables some bacteria to scavenge free fatty acids from the environment for direct use in lipids. This fatty acid recycling pathway can help pathogens circumvent fatty acid synthase (FAS) inhibition with ...
Magdalena Todorinova +2 more
doaj +4 more sources
Decoding allosteric regulation by the acyl carrier protein. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Acyl carrier proteins (ACPs) are involved in primary and secondary metabolic pathways, including the ubiquitous fatty acid biosynthesis, required for all domains of life.
Sztain T +8 more
europepmc +7 more sources
Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase [PDF]
Nature Communications, 2020 Acyl-acyl carrier protein reductase (AAR) and aldehyde deformylating oxygenase (ADO) are the two enzymes in a cyanobacterial alkane biosynthesis pathway that is of interest for biofuel production.
Yu Gao +9 more
doaj +3 more sources
CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases [PDF]
EMBO Molecular Medicine, 2019 PKAN, CoPAN, MePAN, and PDH‐E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA ...
Roald A Lambrechts +10 more
doaj +3 more sources
Journal of Biological Chemistry, 1969 Abstract Holo acyl carrier protein synthetase transfers 4'-phosphopantetheine from reduced coenzyme A to acyl carrier protein (ACP) apoprotein to form ACP holoprotein (holo-ACP). The specificity of this enzyme was tested by using apopeptides derived from ACP. The apopeptides were derived from holopeptides, those containing 4'-phosphopantetheine, by the
Michael D. Greenspan +2 more
+10 more sources
Trapping of the Enoyl-Acyl Carrier Protein Reductase-Acyl Carrier Protein Interaction. [PDF]
Journal of the American Chemical Society, 2016 An ideal target for metabolic engineering, fatty acid biosynthesis remains poorly understood on a molecular level. These carrier protein-dependent pathways require fundamental protein-protein interactions to guide reactivity and processivity, and their ...
Lorillee Tallorin +5 more
semanticscholar +4 more sources
Journal of Biological Chemistry, 1972 β-Ketoacyl-acyl carrier protein (ACP) synthetase catalyzes the chain elongation step of fatty acid biosynthesis, the condensation of fatty acyl-ACP with malonyl-ACP yielding β-ketoacyl-ACP, CO2, and ACP. This enzyme catalyzes two additional reactions, fatty acyl-CoA-ACP transacylation and the decarboxylation of malonyl-ACP to form acetyl-ACP and CO2 ...
Claire H. Birge, P. Roy Vagelos
+7 more sources
Acyl carrier protein promotes MukBEF action in Escherichia coli chromosome organization-segregation [PDF]
Nature Communications, 2021 E. coli MukBEF is an SMC complex that plays key roles in chromosome organization-segregation. Here the authors show that the interaction between MukBEF and the Acyl Carrier Protein (AcpP) is essential for MukBEF activity in vitro (ATPase) and in vivo.
Josh P. Prince +7 more
doaj +2 more sources
Specialized acyl carrier protein used by serine palmitoyltransferase to synthesize sphingolipids in Rhodobacteria [PDF]
Frontiers in Microbiology, 2022 Serine palmitoyltransferase (SPT) catalyzes the first and committed step in sphingolipid biosynthesis condensating L-serine and acyl-CoA to form 3-oxo-sphinganine. Whenever the structural gene for SPT is present in genomes of Rhodobacteria (α-, β-, and γ-
Jonathan Padilla-Gómez +9 more
doaj +2 more sources