Results 1 to 10 of about 110,640 (341)

A broad inhibitor of acyl-acyl carrier protein synthetases [PDF]

Biochemistry and Biophysics Reports, 2023
The acyl-acyl carrier protein synthetase enzyme enables some bacteria to scavenge free fatty acids from the environment for direct use in lipids. This fatty acid recycling pathway can help pathogens circumvent fatty acid synthase (FAS) inhibition with ...
Magdalena Todorinova, Joris Beld, Kara L. Jaremko   +2 more
doaj   +4 more sources

Acyl–Acyl Carrier Protein Desaturases and Plant Biotic Interactions [PDF]

Cells, 2021
Interactions between land plants and other organisms such as pathogens, pollinators, or symbionts usually involve a variety of specialized effectors participating in complex cross-talks between organisms.
Sami Kazaz, Romane Miray, Sébastien Baud   +2 more
doaj   +8 more sources

Acyl Carrier Protein [PDF]

Journal of Biological Chemistry, 1969
Abstract Holo acyl carrier protein synthetase transfers 4'-phosphopantetheine from reduced coenzyme A to acyl carrier protein (ACP) apoprotein to form ACP holoprotein (holo-ACP). The specificity of this enzyme was tested by using apopeptides derived from ACP. The apopeptides were derived from holopeptides, those containing 4'-phosphopantetheine, by the
Michael D. Greenspan, Alfred W. Alberts, P. Roy Vagelos   +2 more
  +10 more sources

Acyl Carrier Protein

Journal of Biological Chemistry, 1972
β-Ketoacyl-acyl carrier protein (ACP) synthetase catalyzes the chain elongation step of fatty acid biosynthesis, the condensation of fatty acyl-ACP with malonyl-ACP yielding β-ketoacyl-ACP, CO2, and ACP. This enzyme catalyzes two additional reactions, fatty acyl-CoA-ACP transacylation and the decarboxylation of malonyl-ACP to form acetyl-ACP and CO2 ...
Claire H. Birge, P. Roy Vagelos
  +7 more sources

Acyl carrier protein promotes MukBEF action in Escherichia coli chromosome organization-segregation [PDF]

Nature Communications, 2021
E. coli MukBEF is an SMC complex that plays key roles in chromosome organization-segregation. Here the authors show that the interaction between MukBEF and the Acyl Carrier Protein (AcpP) is essential for MukBEF activity in vitro (ATPase) and in vivo.
Josh P. Prince, Jani R. Bolla, Gemma L. M. Fisher, Jarno Mäkelä, Marjorie Fournier, Carol V. Robinson, Lidia K. Arciszewska, David J. Sherratt   +7 more
doaj   +2 more sources

Gating mechanism of elongating β-ketoacyl-ACP synthases [PDF]

Nature Communications, 2020
The formation of C-C bonds in fatty acid and polyketide biosynthesis depends on β-ketoacyl-acyl carrier protein (ACP) synthases (KSs). Here, the authors present structures of E.coli KSs bound to substrate mimetic bearing ACPs, providing insights into the
Jeffrey T. Mindrebo, Ashay Patel, Woojoo E. Kim, Tony D. Davis, Aochiu Chen, Thomas G. Bartholow, James J. La Clair, J. Andrew McCammon, Joseph P. Noel, Michael D. Burkart   +9 more
doaj   +2 more sources

Specialized acyl carrier protein used by serine palmitoyltransferase to synthesize sphingolipids in Rhodobacteria [PDF]

Frontiers in Microbiology, 2022
Serine palmitoyltransferase (SPT) catalyzes the first and committed step in sphingolipid biosynthesis condensating L-serine and acyl-CoA to form 3-oxo-sphinganine. Whenever the structural gene for SPT is present in genomes of Rhodobacteria (α-, β-, and γ-
Jonathan Padilla-Gómez, Roberto Jhonatan Olea-Ozuna, Sandra Contreras-Martínez, Orlando Morales-Tarré, Daniela A. García-Soriano, Diana X. Sahonero-Canavesi, Sebastian Poggio, Sergio Encarnación-Guevara, Isabel M. López-Lara, Otto Geiger   +9 more
doaj   +2 more sources

Campylobacter jejuni resistance to human milk involves the acyl carrier protein AcpP [PDF]

mBio
Campylobacter jejuni is a common foodborne pathogen worldwide that is associated with high rates of morbidity and mortality among infants in low- to middle-income countries (LMICs).
Bibi Zhou, Jolene M. Garber, James Butcher, Artur Muszynski, Rebekah L. Casey, Steven Huynh, Stephanie Archer-hartmann, Sara Porfírio, Ashley M. Rogers, Parastoo Azadi, Craig T. Parker, Kenneth K. S. Ng, Kelly M. Hines, Alain Stintzi, Christine M. Szymanski   +14 more
doaj   +2 more sources

Determination of the Protein-Protein Interactions within Acyl Carrier Protein (MmcB)-Dependent Modifications in the Biosynthesis of Mitomycin [PDF]

Molecules, 2021
Mitomycin has a unique chemical structure and contains densely assembled functionalities with extraordinary antitumor activity. The previously proposed mitomycin C biosynthetic pathway has caused great attention to decipher the enzymatic mechanisms for ...
Dongjin Leng, Yong Sheng, Hengyu Wang, Jianhua Wei, Yixin Ou, Zixin Deng, Linquan Bai, Qianjin Kang   +7 more
doaj   +2 more sources

An Acyl Carrier Protein Gene Affects Fatty Acid Synthesis and Growth of Hermetia illucens [PDF]

Insects, 2023
Acyl carrier protein (ACP) is an acyl carrier in fatty acid synthesis and is an important cofactor of fatty acid synthetase. Little is known about ACP in insects and how this protein may modulate the composition and storage of fatty acids.
Xiaoyan Peng, Jiawen Liu, Baoling Li, Shengyin Wang, Bosheng Chen, Dayu Zhang   +5 more
doaj   +2 more sources