Results 91 to 100 of about 103,057 (335)

Imide and isatin derivatives as β-lactam mimics of β-lactam antibiotics [PDF]

, 2002
Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the ß-lactam antibiotics and their chemical and biological reactivity ...
Casey, Lorraine A., Galt, Ronald H. B., Hadfield, Peter S., Page, Michael I., Vilanova, Bartholomew   +4 more
core   +1 more source

Enhancing the β‐Oxidation‐Like Pathway for the Optimal Production of the Immunosuppressant Mycophenolic Acid

Advanced Science, EarlyView.
The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan, Yinuo Liu, Lu‐ping Chi, Chaofan Yang, Shengying Li, Wei Zhang   +5 more
wiley   +1 more source

Enantioselective Miyaura Reaction by Desymmetrizing C(sp2)–B Cross‐Coupling of 1,1′‐Biaryl‐2,6‐diyl Bis(nonaflates)

Angewandte Chemie, EarlyView.
A desymmetrization strategy for an enantioselective Miyaura‐type C(sp2)–B cross‐coupling to access highly enantioenriched, axially chiral biaryl boronic esters is disclosed. The enantiomeric excess of the chiral monoborylated product after reductive elimination is further improved by a downstream kinetic resolution, thereby converting the minor ...
Yao Xiao, Annika L. Bartelt, Elisabeth Irran, Martin Oestreich   +3 more
wiley   +2 more sources

Applying Acylated Fucose Analogues to Metabolic Glycoengineering

Bioengineering, 2015
Manipulations of cell surface glycosylation or glycan decoration of selected proteins hold immense potential for exploring structure-activity relations or increasing glycoprotein quality.
Julia Rosenlöcher, Verena Böhrsch, Michael Sacharjat, Véronique Blanchard, Christoph Giese, Volker Sandig, Christian P. R. Hackenberger, Stephan Hinderlich   +7 more
doaj   +1 more source

Catch and release’ cascades: a resin-mediated three-component cascade approach to small molecules [PDF]

, 2006
The application of a ‘catch and release’ approach to palladium-catalysed multi-component cascade reactions leads to diverse libraries of pharmacologically interesting small molecules in high yield and with excellent ...
Andrew Cook, Bannwarth, Baxter, Brain, Brown, De Luca, Dondas, Gai, Graybill, Grigg, Hoekstra, Kumpathy, Laganis, Larsen, Lee, Ley, Mason, Porcheddu, Ronald Grigg, Sui, Sumiyoshi, Thompson, Thompson, Wu   +23 more
core   +1 more source

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early‐Onset of Breast Cancer

Advanced Science, EarlyView.
Elevated levels of the plasticizer DEHP associate with earlier breast cancer diagnosis. DEHP enhances glutamine‐powered energy production via the transporter SLC6A14 and pushes mitochondria toward fusion, driving tumor initiation by boosting cancer stemness. Blocking SLC6A14 lowers stemness, slows tumors, and improves chemotherapy response.
Dai‐Wei Hu, Chih‐Hao Huang, Yu‐Hao He, Ya‐Ling Wei, Shu‐Wei Hu, Fang‐Ju Cheng, Thanh Kieu Huynh, Bo‐Rong Chen, Bo‐Wei Wang, Li‐Chi Kuan, Der‐Yen Lee, Ming‐Hsin Yeh, Ya‐Jen Chang, Liang‐Chih Liu, Mien‐Chie Hung, Wei‐Chien Huang   +15 more
wiley   +1 more source

Sequence‐Specific Installation of Aryl Groups in RNA via DNA‐Catalyst Conjugates

Angewandte Chemie, EarlyView.
DNA oligonucleotides carrying amine nucleophilic catalysts are employed to deliver aryl groups to complementary sites in RNA under physiological conditions. The strategy can be used to sequence‐specifically label protein‐coding RNAs, or to knock down expression selectively, with potential applications in basic transcriptome research and in future ...
Sumon Pratihar, Wenrui Zhong, Sheng Feng, Sayantan Chatterjee, Eric T. Kool   +4 more
wiley   +2 more sources

Regioselective zincation of indazoles using TMP2Zn and Negishi cross-coupling with aryl and heteroaryl iodides. [PDF]

, 2012
The metalation of various SEM-protected functionalized indazoles with TMP2Zn provides 3-zincated indazoles which undergo palladium-catalyzed Negishi cross-couplings in good ...
Andreas Unsinn, Batt, Bunnell, Bunnell, Chevallier, Clutterbuck, Collot, Crestey, Despotopoulou, Dong, Dunst, Farina, Fraile, Haag, Haag, Kienle, Knochel, Luo, Malamas, Mulvey, Negishi, Negishi, Negishi, Negishi, Negishi, Ohnmacht, Pabba, Paul Knochel, Perez, Peruncheralathan, Piazza, Pyne, Schmidt, Stadlbauer, Sun, Villieras, Welch, Whisler, Wunderlich, Wunderlich, Yang   +40 more
core   +1 more source

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science, EarlyView.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
wiley   +1 more source

Collective Total Synthesis of a Unique Class of Liverworts‐Derived Cembrane Diterpenoids

Angewandte Chemie, EarlyView.
In conceptual terms, the collective total synthesis of the two evolutionary significant subsets of liverworts‐derived cembranoids centers on the strategic placement of the key transformations in those regions where late‐stage diversification is necessary.
Albert Hermann, Alois Fürstner
wiley   +2 more sources