Results 91 to 100 of about 1,578 (184)

FeCl3‐Catalyzed Synthesis of Ynones from Silylated Alkynes and Acetic Anhydride

ChemistryOpen, EarlyView.
The synthesis of alkynones from silylated alkynes and acid chlorides, first reported by Birkhofer in 1963, remains a valuable transformation. However, its reliance on stoichiometric AlCl3 and corrosive reagents raises environmental and practical concerns. To address this, a greener protocol using catalytic FeCl3 and acetic anhydride is developed.
Paul Charki, Urs Gellrich, Daniel S. Müller   +2 more
wiley   +1 more source

Tuning adsorption and morphology in poly(glutamic acid) via controlled acidic partial deprotection

Polymer International, EarlyView.
Partial deprotection of poly(glutamic acid) generates morphologies and assemblies that match fully deprotected polypeptides in small‐molecule adsorption, extending to block copolypeptides with pH‐dependent effects. Abstract Synthetic polypeptides prepared from N‐carboxyanhydride (NCA) monomers are important platforms for environmental and medical ...
Hunter Wood, Stella Trickett, Joseph Dosch, Farin Weinger, Dan Flaherty, Stefanie Sydlik   +5 more
wiley   +1 more source

Proteome‐Wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights Into Early Immune Signaling

PROTEOMICS, EarlyView.
ABSTRACT Protein S‐palmitoylation, a reversible lipid modification, plays critical roles in regulating protein function and localization. However, its comprehensive role in the rapid reprogramming of macrophages during early immune responses remains incompletely understood.
Hyojung Kim, Jiraphorn Issara‐Amphorn, Sung Hwan Yoon, Anirban Banerjee, Aleksandra Nita‐Lazar   +4 more
wiley   +1 more source

Vegetable Oil–Mediated Transesterification as a Green Route to Tune Ethyl Cellulose Properties

Journal of Polymer Science, EarlyView.
An environmentally conscious strategy for augmenting the hydrophobicity of ethyl cellulose polymer via a transesterification reaction using renewable vegetable oil. ABSTRACT The inherent hydrophilicity of biopolymers presents significant limitations to their implementation, particularly in coating and packaging applications.
Athira Narayanan, Valeria D'Errico, Marco Friuli, Sonia Bagheri, Claudio Mele, Alessandro Sannino, Christian Demitri, Leonardo Lamanna   +7 more
wiley   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

University teaching of mass spectrometry as a key practical technique within the context of a fully integrated, spiral curriculum

Rapid Communications in Mass Spectrometry, EarlyView.
Rationale Mass spectrometry (MS) is introduced to high school students in the UK in many pre‐university course syllabi. As such, we have identified the use of MS as a key technique that should be taught practically to undergraduates from the outset of their studies.
Andrew F. Worrall, Craig D. Campbell, Megan O. Midson, Malcolm I. Stewart   +3 more
wiley   +1 more source

Catalytic Scalable Synthesis of Polyketides Enabled by Chiral Brønsted Acid‐Catalyzed Asymmetric Allylborations

The Chemical Record, EarlyView.
The scalable synthesis of target molecules is crucial for applications such as biological evaluation in medicinal chemistry and even industrial production. We described recent advances in chiral Brønsted acid–catalyzed asymmetric allylboration, which enables access to previously elusive chiral building blocks, and highlight its application to the ...
Shigenobu Umemiya, Masahiro Terada
wiley   +1 more source

Cutting‐edge advances in bicyclic peptide‐based radiotracers for cancer imaging and theranostics

VIEW, EarlyView.
Abstract Along with successful clinical approval of radiopharmaceuticals targeting somatostatin receptor subtype 2 and prostate‐specific membrane antigen, peptide‐based radiotracers have garnered the increasing attention in cancer imaging and theranostics. As a newly emerging targeting ligand in recent years, bicyclic peptides have demonstrated immense
Hengyi Ou, Xiaobo Wang, Fei Kang
wiley   +1 more source

Unimolecular GLP‐1/Apelin Hybrid Peptides Cause Prominent Appetite Suppression, as Well as Enhancing Insulin Secretion, Beta‐Cell Survival and Glycaemic Regulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To characterise the metabolic benefits of a GLP‐1/apelin hybrid peptide, namely exendin‐4‐linker‐apelin (ELA), and associated acylated forms, including ELA‐Lys12(γGluPal), ELA‐Lys27(γGluPal) and ELA‐Lys38(γGluPal). Methods Concentration‐ and receptor‐dependent effects of the peptides on insulin secretion and beta‐cell turnover were ...
Ananyaa Sridhar, Ethan S. Palmer, Sarah L. Craig, Elzbieta Krason‐Kidzinska, Nigel Irwin, Finbarr P. M. O'Harte   +5 more
wiley   +1 more source