Results 111 to 120 of about 89,225 (346)

S-Acylation of Neuronal Transport Machinery: A Focused Exploration of p150Glued S-Acylation in Neurons [PDF]

Neurons require efficient trafficking and delivery of neuronal proteins and organelles to specific subcellular locations. Dynein and kinesin motors mediate long-distance transport of cargo along microtubules spanning the axon to maintain neuronal ...
Doerksen, Amelia
core   +2 more sources

Protein S-acylation in plants (Review) [PDF]

, 2009
Membrane resident proteins are a common feature of biology yet many of these proteins are not integral to the membrane. These peripheral membrane proteins are often bound to the membrane by the addition of fatty acyl chains to the protein.
Hemsley, Piers A; id_orcid
core   +1 more source

Live-Cell Epigenome Manipulation by Synthetic Histone Acylation Catalyst System [PDF]

, 2020
Chemical modifications of histones play a pivotal role in the epigenome and regulation of gene expression, and their abnormality is tightly linked to numerous disease states in humans.
Yuko, Sato, Shigehiro, Kawashima, Yusuke, Fujiwara, Motomu, Kanai, Tomoya, Kujirai, Hitoshi, Kurumizaka, Kenzo, Yamatsugu, Hiroshi, Kimura, Yuki, Yamanashi   +8 more
core   +1 more source

S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

eLife
NLRP3 is an inflammasome seeding pattern recognition receptor activated in response to multiple danger signals which perturb intracellular homeostasis.
Daniel M Williams, Andrew A Peden
doaj   +1 more source

The chemistry and applications of RNA 2′-OH acylation

Nature Reviews Chemistry, 2019
RNA is a versatile biomolecule with a broad range of biological functions that go far beyond its initially described role as a simple information carrier.
W. A. Velema, E. Kool
semanticscholar   +1 more source

Anomeric Amide Enabled Divergent Synthesis of Unsymmetrical Ureas, Carbamates, Thioesters, and Amides From Aldehydes

Angewandte Chemie International Edition, EarlyView.
An anomeric amide‐enabled divergent aldehyde functionalization sequence provides one‐pot access to unsymmetrical ureas, carbamates, thiocarbamates, thioesters, and amides. Key to this transformation is the formation of N‐Boc‐hydroxamate intermediates, which serve as platforms for orthogonal activation via Lossen‐type rearrangements, single‐electron ...
Jasper L. Tyler, Meiyi Zeng, Julius Wiener, Marie‐Christin Leusmann, Colin Stein, Constantin G. Daniliuc, Frank Glorius   +6 more
wiley   +1 more source

Acylation through Ketene Intermediates [PDF]

, 2016
Carboxylic acids possessing a strong electron-withdrawing group in the α-position undergo facile dehydration upon reaction with carbodiimides to form the corresponding substituted ketenes that can react in situ with alcohols providing esters in a high ...
Artem Melman (2055379), Rimma Shelkov (2298766), Moshe Nahmany (2534557)   +2 more
core   +1 more source

DHHC enzymes in alphavirus glycoprotein acylation: A target for broad-spectrum antiviral therapy

Cell Reports
Summary: Alphaviruses are mosquito-transmitted viruses that cause severe zoonotic diseases. Their envelope glycoproteins, E1 and E2, undergo cysteine acylation, a process critical for virus infection but previously undefined mechanistically.
Xiaoling Li, Chaoyun Han, Wanjie Song, Zhiwen Jiang, Yunbiao Lu, Sainan Wang, Jie Chen, Yu Deng, Andres Merits, Wan-Ting He, Shuo Su, Michael Veit   +11 more
doaj   +1 more source

Optimized Enzymatic Synthesis of Hesperidin Fatty Acid Esters in a Two-Phase System Containing Ionic Liquid

Molecules, 2011
Response surface methodology (RSM) based on a five-level, three-variable central composite design (CCD) was employed for modeling and optimizing the conversion yield of the enzymatic acylation of hesperidin with decanoic acid using immobilized Candida ...
Yollanda Edwirges Moreira Franco, Alexandra C.H. Frankland Sawaya, Thiago Grando Alberto, Patrícia de Oliveira Carvalho, Natália Dalfré, Fabiano Jares Contesini, Maria Elisa Melo Branco de Araújo   +6 more
doaj   +1 more source

Design‐Driven Production of Soybean Oil‐Based Structured Fats as Potential Substitutes for Palm‐Based Fats

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT This study examined whether enzymatic modification of soybean oil (SBO) can be tailored to produce trans‐free fats with physicochemical properties comparable to palm olein, stearin, or palm‐mid fractions (PMFs). US‐grown SBO was modified by lipase‐catalyzed acidolysis using palmitic acid at linearly interpolated substrate molar ratios (C16:0 ...
Ityotagher P. Aondoakaa, Silvana Martini, Casimir C. Akoh   +2 more
wiley   +1 more source