Results 131 to 140 of about 89,225 (346)
An efficient method for acylation reactions [PDF]
, 1999 Cu(OTf)2 was found to be an efficient catalyst in the acylation reaction of alcohols, phenols, amines and thiols with acetic anhydride in CH2Cl2 or acetic acid.
Saravanan, Parthasarathy +3 more
core +1 more source
RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging
Biological Reviews, EarlyView.ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad +5 more
wiley +1 more source
The impact of maternal obesity and gestational diabetes mellitus on adipose tissue and placental derived adipocytokines [PDF]
Pregnancy; a natural insulin resistant state; becomes exaggerated when complicated by obesity and gestational diabetes (GDM). Both obesity and GDM are associated with severe maternal and fetal complications as well as with increased risks of obesity ...
Sivakumar, Kavitha
core
Sequestering sequestosome 1 via S-acylation in autophagy, Huntington disease, and beyond
Autophagy ReportsProtein mislocalization and aggregation are hallmark features in neurodegeneration. As proteins mislocalize, proteostasis deficiency and protein aggregation typically follow.
Y Alshehabi, F Abrar, D.D.O Martin
doaj +1 more source
A Small Molecule SIRT2 Inhibitor that Promotes K-Ras4a Lysine Fatty-acylation
ChemMedChem, 2019 SIRT2, a member of the sirtuin family of protein lysine deacylases, has been identified as a promising therapeutic target for treating cancer. In addition to catalyzing deacetylation, SIRT2 has recently been shown to remove fatty acyl groups from K‐Ras4a
Nicole A Spiegelman +9 more
semanticscholar +1 more source
Chemistry – A European Journal, EarlyView.ABSTRACT Over the past twenty years, main group chemistry has significantly expanded its scope to include reactivities once considered the exclusive domain of transition metals. Among the emerging concepts, element‐ligand cooperation has proven to be a powerful strategy for enabling bond activation reactions but remains relatively unexplored for ...
Lennart Hensle, Viktoria H. Gessner
wiley +1 more source
Acylation of ω-phenylalkanoylferrocenes by cinnamoyl and phenylpropiolyl chlorides [PDF]
, 1987 In Friedel-Crafts acylation of ω-phenylalkanoylferrocenes, the site of electrophilic attack depends on the reagent used. The acylation with cinnamoyl chloride yields preferentially the products of substitution of the unsubstituted cyclopentadienyl ring ...
Marta Sališová, Štefan Toma
core +1 more source
Журнал органічної та фармацевтичної хімії, 2019 Aim. To synthesize new derivatives based on hexamethylene(ethylene)-N,N’-bis(spiroindole-3,3’-pyrrolo-[3,4-c]pyrrole-2a,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trions) and 1’-(m-phenylene-N-maleimidido)-2a’,5a’-dihydro-1’H- spiroindole-3,3’-pyrrolo[3,4-c]pyrrole-
Yevheniia I. Siumka +5 more
doaj +1 more source
The molecular era of protein S-acylation: spotlight on structure, mechanisms, and dynamics
Critical reviews in biochemistry and molecular biology, 2018 S-Acylation (commonly referred to as S-palmitoylation) is a post-translational modification consisting in the covalent attachment of an acyl chain to a cysteine residue of the target protein. The lability of the resulting thioester bond gives S-acylation
M. Zaballa, F. G. van der Goot
semanticscholar +1 more source
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, EarlyView.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source