Results 141 to 150 of about 89,225 (346)
Identification of acylation products in SHAPE Chemistry [PDF]
, 2017 International audienceSHAPE chemistry (selective 2’-hydroxyl acylation analyzed by primer extension) has been developed to specifically target flexible nucleotides (often unpaired nucleotides) independently to their purine or pyrimidine nature for RNA ...
Olivier Mauffret +13 more
core +1 more source
Applying Acylated Fucose Analogues to Metabolic Glycoengineering
Bioengineering, 2015 Manipulations of cell surface glycosylation or glycan decoration of selected proteins hold immense potential for exploring structure-activity relations or increasing glycoprotein quality.
Julia Rosenlöcher +7 more
doaj +1 more source
Fatty Acylation of Proteins: The Long and the Short of it
Progress in lipid research, 2016 Long, short and medium chain fatty acids are covalently attached to hundreds of proteins. Each fatty acid confers distinct biochemical properties, enabling fatty acylation to regulate intracellular trafficking, subcellular localization, protein-protein ...
M. Resh
semanticscholar +1 more source
Chemistry – A European Journal, EarlyView.Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato +3 more
wiley +1 more source
Functional Group Tolerance in Organocatalytic Regioselective Acylation of Carbohydrates [PDF]
, 2016 Organocatalytic regioselective acylation of mono- and disaccaharides with various functionalized acid anhydrides has been developed. Acylation of octyl β-d-glucopyranoside with acid anhydrides derived from α-amino acids, cinnamic acid, and gallic acid ...
Kenji Mishiro (1910746) +4 more
core +1 more source
Improvement of plant resistance to geminiviruses via protein de-S-acylation
Stress BiologyGeminiviruses are an important group of viruses that infect a variety of plants and result in heavy agricultural losses worldwide. The homologs of C4 (or L4) in monopartite geminiviruses and AC4 (or AL4) in bipartite geminiviruses are critical viral ...
Yawen Zhao +11 more
doaj +1 more source
Nature Microbiology, 2018 Shigella flexneri, an intracellular Gram-negative bacterium causative for shigellosis, employs a type III secretion system to deliver virulence effectors into host cells. One such effector, IcsB, is critical for S.
Wang Liu +10 more
semanticscholar +1 more source
Precision Chemistry for Protein Lysine Modification
Chemistry – A European Journal, EarlyView.Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley +1 more source
Cross‐Dehydrogenative Coupling Reactions With Redox‐Active Guanidine Reagents
Chemistry – A European Journal, EarlyView.ABSTRACT Cross‐dehydrogenative coupling (CDC) reactions are attractive and environmentally friendly ways to form new C‐C and other element‐element bonds. Here, we report the first CDC reactions triggered by a redox‐active guanidine reagent. N‐phenyltetrahydroisoquinoline and derivatives with electron‐donating and withdrawing substituents at the N ...
Petra Walter +2 more
wiley +1 more source
Synthesis of the Core Tetracycle of the Spirobiflavonoid Daphnodorin C
European Journal of Organic Chemistry, EarlyView.Core spirotetracycle of daphnodorin C: Oxidative ring contraction of benzofuro[3,2‐b]chromenones affords novel 2,3′‐spirobi[benzofuran]diones, rather than the isomeric spiroketals. The first synthesis of the spirobi[benzofuran]dione core structure of the spirobiflavonoid daphnodorin C is described.
Lukas Heemann +2 more
wiley +1 more source