The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis
Journal of Periodontal Research, EarlyView.Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis +2 more
wiley +1 more source
Stereoselective formation of a 2 prime (3 prime)- aminoacyl ester of a nucleotide [PDF]
Reaction of DL-series and adenosine-5-phosphorimidazolide in the presence of adenosine-5'-(0-methylphosphate) and imidazole resulted in the stereoselective synthesis of the aminoacyl nucleotide ester, 2'(3')-0-seryl-adenosine-5'-(0-methylphosphate).
Weber, A. L.
core +1 more source
The Oral‐Gut Axis: Bidirectional Interactions Between Microbiome and Diseases
Journal of Periodontal Research, EarlyView.This study aims to summarize the mechanisms underlying ectopic colonization of the gut by oral pathobionts and the microbial and host factors that regulate this process. ABSTRACT Increased colonization of typically oral microorganisms is frequently observed in the gut mucosa or lumen of individuals with gastrointestinal disorders, including patients ...
Shinya Ebihara, Nobuhiko Kamada
wiley +1 more source
Correction: Acylation of Lysine 983 Is Sufficient for Toxin Activity of Bordetella pertussis Adenylate Cyclase. [PDF]
J Biol ChemBasar T +4 more
europepmc +1 more source
Sweet Potato Gene Clusters Control Anthocyanin Biosynthesis and Leaf Morphology
Plant Biotechnology Journal, EarlyView.ABSTRACT Sweet potato (Ipomoea batatas) exhibits diversity in pigmentation and leaf morphology, yet the genetic architecture and regulatory organisation underlying these traits remain poorly resolved, particularly with respect to organ‐specific control.
Dong An +13 more
wiley +1 more source
Phylogenomic Insights into High Conservation and Lineage-Specific Expansion of the ABAPT Gene Family in Plants. [PDF]
Int J Mol SciSong H +8 more
europepmc +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Thermo‐sensitive genic male sterility (TGMS) lines play a pivotal role in two‐line hybrid rice breeding. However, the availability of elite TGMS germplasm remains limited, and the molecular mechanisms underlying fertility transition of TGMS lines are still poorly understood.
Siqi Cheng +33 more
wiley +1 more source
Screening anticancer peptides performance in organotypic prostate tumor‐stroma 3D models
International Journal of Cancer, Volume 158, Issue 11, Page 2936-2946, 1 June 2026.What's new? Peptide‐based drugs have emerged as promising anticancer therapies for their potential to disrupt protein–protein interactions. In this study, the authors developed a physiomimetic human 3D prostate cancer spheroid model to assess the efficacy of the CAVPENET peptide in inhibiting tumor growth. Upon incubation with CAVPENET, prostate cancer
Bárbara Matos +7 more
wiley +1 more source
C-terminal S-acylation governs membrane distribution, interaction dynamics and function of a plant Rho GTPase. [PDF]
PLoS OneAkerman A +5 more
europepmc +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.ABSTRACT Background Chronic obstructive pulmonary disease (COPD) is associated with musculoskeletal comorbidities, including cachexia. Weight loss (WL) is the major criterion for cachexia and increases risk for mortality in COPD. Risk factors for WL in COPD are incompletely understood.
Joe W. Chiles III +23 more
wiley +1 more source