Results 11 to 20 of about 51,515 (263)

Aldehydes: magnificent acyl equivalents for direct acylation [PDF]

Organic & Biomolecular Chemistry, 2020
This review sheds light on the use of aldehydes in the selective acylation of arene, heteroarene and alkyl (sp3, sp2and sp) C–H bonds by proficient utilization of the C–H activation strategy.
Kumar, Prashant, Dutta, Sriparna, Kumar, Sandeep, Bahadur, Vijay, van der Eycken, Erik V., Vimaleswaran, Karani Santhanarishnan, Parmar, Virinder S., Singh, Brajendra K.   +7 more
openaire   +4 more sources

Acyl-Lipid Metabolism [PDF]

The Arabidopsis Book, 2010
Acyl lipids in Arabidopsis and all other plants have a myriad of diverse functions. These include providing the core diffusion barrier of the membranes that separates cells and subcellular organelles. This function alone involves more than 10 membrane lipid classes, including the phospholipids, galactolipids, and sphingolipids, and within each class ...
Li-Beisson, Yonghua, Shorrosh, Basil, Beisson, Fred, Andersson, Mats X., Arondel, Vincent, Bates, Philippe D., Baud, Sebastien, Bird, David, Debono, Allan, Durrett, Timithy P., Franke, Rochus B., Graham, Ian A., Katayama, Kenta, Kelly, Amelie A., Larson, Tony, Markham, Jonathan E., Miquel, Martine, Molina, Isabel, Nishida, Ikuo, Rowland, Owen, Samuels, Lacey, Schmid, Katherine M., Wada, Hajime, Welti, Ruth, Xu, Changcheng, Zallot, Rémi, Ohlrogge, John   +26 more
openaire   +6 more sources

SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a

eLife, 2017
Ras proteins play vital roles in numerous biological processes and Ras mutations are found in many human tumors. Understanding how Ras proteins are regulated is important for elucidating cell signaling pathways and identifying new targets for treating ...
Hui Jing, Xiaoyu Zhang, Stephanie A Wisner, Xiao Chen, Nicole A Spiegelman, Maurine E Linder, Hening Lin   +6 more
doaj   +1 more source

Optimization of the Enzymatic Acylation Reaction Conditions of Vitis davidii Malvidin

Shipin gongye ke-ji, 2022
In order to increase the structural stability of anthocyanins, taking Vitis davidii malvidin as sample and the lipase CAL-B as catalyst, the effects of reaction time, temperature, and substrate molar ratio on enzymatic acylation were investigated.
Aili CAI, Mingyong HUANG, Zheng WANG, Yabo GUO, Qian ZHAO, Jiehong DENG   +5 more
doaj   +1 more source

Regulation of ERK2 activity by dynamic S-acylation

Cell Reports, 2023
Summary: Extracellular signal-regulated kinases (ERK1/2) are key effector proteins of the mitogen-activated protein kinase pathway, choreographing essential processes of cellular physiology.
Saara-Anne Azizi, Tian Qiu, Noah E. Brookes, Bryan C. Dickinson   +3 more
doaj   +1 more source

Site-specific analysis of protein S-acylation by resin-assisted capture[S]

Journal of Lipid Research, 2011
Protein S-acylation is a major posttranslational modification whereby a cysteine thiol is converted to a thioester. A prototype is S-palmitoylation (fatty acylation), in which a protein undergoes acylation with a hydrophobic 16 carbon lipid chain ...
Michael T. Forrester, Douglas T. Hess, J. Will Thompson, Rainbo Hultman, M. Arthur Moseley, Jonathan S. Stamler, Patrick J. Casey   +6 more
doaj   +1 more source

Cycvalone in the synthesis of nitrogen-, oxygen-containing heterocycles [PDF]

Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология, 2023
Cycvalone is an analogue of curcumin (EE conformation), exhibits a wide range of biological activity (antioxidant, hepatoprotective, membrane stabilizing, anti-ulcer) and is used in medical practice as a choleretic.
Rogov, Danila A., Krivenko, Adel Pavlovna   +1 more
doaj   +1 more source

The enzyme activity of mitochondrial trifunctional protein is not altered by lysine acetylation or lysine succinylation.

PLoS ONE, 2021
Mitochondrial trifunctional protein (TFP) is a membrane-associated heterotetramer that catalyzes three of the four reactions needed to chain-shorten long-chain fatty acids inside the mitochondria.
Yuxun Zhang, Eric Goetzman
doaj   +1 more source

The effect of acylation with fatty acids and other modifications on HLA class II:peptide binding and T cell stimulation for three model peptides. [PDF]

PLoS ONE, 2018
Immunogenicity is a major concern in drug development as anti-drug antibodies in many cases affect both patient safety and drug efficacy. Another concern is often the limited half-life of drugs, which can be altered by different chemical modifications ...
Heidi S Schultz, Søren Østergaard, John Sidney, Kasper Lamberth, Alessandro Sette   +4 more
doaj   +1 more source

Pharmacological Activities and Chemical Stability of Natural and Enzymatically Acylated Anthocyanins: A Comparative Review

Pharmaceuticals, 2023
Anthocyanins (ANCs) are naturally occurring water-soluble pigments responsible for conferring red, blue, and purple colors to fruits, vegetables, flowers, and grains. Due to their chemical structure, they are highly susceptible to degradation by external
Jimena Yañez-Apam, Astrid Domínguez-Uscanga, Azucena Herrera-González, Jonhatan Contreras, Luis Mojica, Gail Mahady, Diego A. Luna-Vital   +6 more
doaj   +1 more source