Results 241 to 250 of about 89,225 (346)

From Brewing to Plastic Degradation: Uncovering the Polyurethanase Potential of <i>R. chinensis</i> Lipase through Atomistic Simulations. [PDF]

J Am Chem Soc
de Sousa Batista V, Ṡwiderek K, Moliner V.   +2 more
europepmc   +1 more source

Acid‐Catalyzed Rearrangement Reaction for Single‐Molecule Junction Formation

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
Hydrazobenzenes cannot form single‐molecule devices with gold electrodes in a nonpolar solvent, but with the addition of trifluoroacetic acid, robust single‐molecule junctions are created. Hydrazobenzenes likely undergo rearrangement reactions to form benzidines, which are then attached to gold contacts by dative NH2→Au interactions for junction ...
Yihao Zhang, Yunlong Li, Zhenpin Lu, Haixing Li   +3 more
wiley   +1 more source

Editorial: Unraveling enzyme-substrate dynamics in protein acylation and disease implications. [PDF]

Front Mol Biosci
Cheng S, Liu T, Xing J, Zhang G, Zhang L, Zhao W.   +5 more
europepmc   +1 more source

Proximity-driven acceleration of challenging solid-phase peptide couplings. [PDF]

Proc Natl Acad Sci U S A
Parker J, Farrell BA, Kohuth KA, Parker L, Abboud SA, Kodadek T.   +5 more
europepmc   +1 more source

Dilithium Enediamide Derived From a 1,4‐Diaza‐1,3‐diene: Reactivity of a Strongly N‐Basic, Highly C‐Nucleophilic Compound Toward C–H Acids

European Journal of Inorganic Chemistry, Volume 29, Issue 20, 17 July 2026.
The lithium enediamide complex 2 with intrinsically inverted C–N bond polarity combines strong basicity with unusual reactivity: deprotonation of malonates enables C–C bond formation without electron transfer. Depending on malonate substitution, electrophilic substitution or addition occurs at the enediamide CC bond.
Muhan Liang, Michael Kunze, Helmar Görls, Joachim Scholz   +3 more
wiley   +1 more source

Multi-step biocatalytic strategy to produce a library of original xylosides with various ester functions for cosmetic applications. [PDF]

RSC Adv
Jolly E, Muzard M, Plantier-Royon R, Rémond C.   +3 more
europepmc   +1 more source

Total Synthesis of Sacrolide A and Cytotoxic Evaluation

European Journal of Organic Chemistry, Volume 29, Issue 27, 17 July 2026.
Isolated from the edible cyanobacterium Aphanothece sacrum, sacrolide A is a highly potent antimicrobial and cytotoxic metabolite. Its total synthesis via a convergent strategy enabled accurate assessment of its effects on liver and colon cells, offering new insights into its bioactivity and potential health risks.
Priyanka Kataria, Kamel Hadj‐Kaddour, Alexis Giraudon, Jawad Belkheir, Alexandre Guy, Thierry Durand, Magali Gary‐Bobo, Camille Oger   +7 more
wiley   +1 more source

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain‐Containing Proteins

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley   +1 more source