Results 21 to 30 of about 51,515 (263)

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

eLife, 2021
Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel
Amado Carreras-Sureda, Laurence Abrami, Kim Ji-Hee, Wen-An Wang, Christopher Henry, Maud Frieden, Monica Didier, F Gisou van der Goot, Nicolas Demaurex   +8 more
doaj   +1 more source

SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

eLife, 2017
The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors. Understanding their regulation is thus important for studying biology and human diseases.
Xiaoyu Zhang, Nicole A Spiegelman, Ornella D Nelson, Hui Jing, Hening Lin   +4 more
doaj   +1 more source

Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

eLife, 2021
Protein acylation is critical for many cellular functions across all domains of life. In bacteria, lipoproteins have important roles in virulence and are targets for the development of antimicrobials and vaccines. Bacterial lipoproteins are secreted from
Christopher Icke, Freya J Hodges, Karthik Pullela, Samantha A McKeand, Jack Alfred Bryant, Adam F Cunningham, Jeff A Cole, Ian R Henderson   +7 more
doaj   +1 more source

Discovery of Anthocyanin Acyltransferase1 (AAT1) in Maize Using Genotyping-by-Sequencing (GBS)

G3: Genes, Genomes, Genetics, 2018
The reduced acylation phenotype describes the inability of certain accessions of maize (Zea mays [L.]) to produce significant amounts of acylated anthocyanins, which are typically the most abundant pigments.
Michael N. Paulsmeyer, Patrick J. Brown, John A. Juvik   +2 more
doaj   +1 more source

Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases

Frontiers in Immunology, 2021
Protein S-palmitoylation is a covalent and reversible lipid modification that specifically targets cysteine residues within many eukaryotic proteins. In mammalian cells, the ubiquitous palmitoyltransferases (PATs) and serine hydrolases, including acyl ...
Yuqi Zhang, Ziran Qin, Wenhuan Sun, Feng Chu, Fangfang Zhou   +4 more
doaj   +1 more source

Homeoviscous Adaptation of the Acinetobacter baumannii Outer Membrane: Alteration of Lipooligosaccharide Structure during Cold Stress

mBio, 2021
To maintain optimal membrane dynamics, cells from all domains of life must acclimate to various environmental signals in a process referred to as homeoviscous adaptation.
Carmen M. Herrera, Bradley J. Voss, M. Stephen Trent   +2 more
doaj   +1 more source

Assaying protein palmitoylation in plants

Plant Methods, 2008
Background Protein S-acylation (also known as palmitoylation) is the reversible post-translational addition of acyl lipids to cysteine residues in proteins through a thioester bond. It allows strong association with membranes.
Taylor Laura, Hemsley Piers A, Grierson Claire S   +2 more
doaj   +1 more source

Research Progress on Acylation Modification and Application of Animal and Vegetable Proteins [PDF]

Shipin Kexue
Acylation is a common method for chemical modification of proteins, which can effectively improve the functional properties of proteins and has been widely used in food processing in recent years.
YAO Xuan, LÜ Xiaohui, JIN Yongguo, HU Gan
doaj   +1 more source

Versatility of Acyl-Acyl Carrier Protein Synthetases

Chemistry & Biology, 2014
The acyl carrier protein (ACP) requires posttranslational modification with a 4'-phosphopantetheine arm for activity, and this thiol-terminated modification carries cargo between enzymes in ACP-dependent metabolic pathways. We show that acyl-ACP synthetases (AasSs) from different organisms are able to load even, odd, and unnatural fatty acids onto E ...
Beld, Joris, Finzel, Kara, Burkart, Michael D.   +2 more
openaire   +2 more sources

Chiral isothiourea-catalyzed kinetic resolution of 4-hydroxy[2.2]paracyclophane

Beilstein Journal of Organic Chemistry, 2021
We herein report a method for the kinetic resolution of racemic 4-hydroxy[2.2]paracyclophane by means of a chiral isothiourea-catalyzed acylation with isobutyric anhydride.
David Weinzierl, Mario Waser
doaj   +1 more source