Results 21 to 30 of about 1,578 (184)
SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a
eLife, 2017 Ras proteins play vital roles in numerous biological processes and Ras mutations are found in many human tumors. Understanding how Ras proteins are regulated is important for elucidating cell signaling pathways and identifying new targets for treating ...
Hui Jing +6 more
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Optimization of the Enzymatic Acylation Reaction Conditions of Vitis davidii Malvidin
Shipin gongye ke-ji, 2022 In order to increase the structural stability of anthocyanins, taking Vitis davidii malvidin as sample and the lipase CAL-B as catalyst, the effects of reaction time, temperature, and substrate molar ratio on enzymatic acylation were investigated.
Aili CAI +5 more
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Site-specific analysis of protein S-acylation by resin-assisted capture[S]
Journal of Lipid Research, 2011 Protein S-acylation is a major posttranslational modification whereby a cysteine thiol is converted to a thioester. A prototype is S-palmitoylation (fatty acylation), in which a protein undergoes acylation with a hydrophobic 16 carbon lipid chain ...
Michael T. Forrester +6 more
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PLoS ONE, 2021 Mitochondrial trifunctional protein (TFP) is a membrane-associated heterotetramer that catalyzes three of the four reactions needed to chain-shorten long-chain fatty acids inside the mitochondria.
Yuxun Zhang, Eric Goetzman
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Cycvalone in the synthesis of nitrogen-, oxygen-containing heterocycles [PDF]
Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология, 2023 Cycvalone is an analogue of curcumin (EE conformation), exhibits a wide range of biological activity (antioxidant, hepatoprotective, membrane stabilizing, anti-ulcer) and is used in medical practice as a choleretic.
Rogov, Danila A. +1 more
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The effect of acylation with fatty acids and other modifications on HLA class II:peptide binding and T cell stimulation for three model peptides. [PDF]
PLoS ONE, 2018 Immunogenicity is a major concern in drug development as anti-drug antibodies in many cases affect both patient safety and drug efficacy. Another concern is often the limited half-life of drugs, which can be altered by different chemical modifications ...
Heidi S Schultz +4 more
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Regulation of ERK2 activity by dynamic S-acylation
Cell Reports, 2023 Summary: Extracellular signal-regulated kinases (ERK1/2) are key effector proteins of the mitogen-activated protein kinase pathway, choreographing essential processes of cellular physiology.
Saara-Anne Azizi +3 more
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Pharmaceuticals, 2023 Anthocyanins (ANCs) are naturally occurring water-soluble pigments responsible for conferring red, blue, and purple colors to fruits, vegetables, flowers, and grains. Due to their chemical structure, they are highly susceptible to degradation by external
Jimena Yañez-Apam +6 more
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SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
eLife, 2017 The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors. Understanding their regulation is thus important for studying biology and human diseases.
Xiaoyu Zhang +4 more
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eLife, 2021 Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel
Amado Carreras-Sureda +8 more
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