Results 21 to 30 of about 102,908 (194)

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

open access: yeseLife, 2021
Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel
Amado Carreras-Sureda   +8 more
doaj   +1 more source

Synthesis and properties of lipoamino acid/fatty acid mixtures. Influence of the amphiphilic structure. [PDF]

open access: yes, 2009
The acylation of amino acids by acid chlorides with from 8 to 12 carbon atoms, in alkaline aqueous medium following Shotten-Baumann reaction, results in sodium salts of Nα-acylamino acids and fatty acids mixture. These lastest are present in proportion
Alric, Isabelle   +4 more
core   +2 more sources

Green Production of Anionic Surfactant Obtained from Pea Protein [PDF]

open access: yes, 2011
A pea protein isolate was hydrolyzed by a double enzyme treatment method in order to obtain short peptide sequences used as raw materials to produce lipopeptides-based surfactants.
A Clemente   +40 more
core   +1 more source

Examining the Underappreciated Role of S-Acylated Proteins as Critical Regulators of Phagocytosis and Phagosome Maturation in Macrophages

open access: yesFrontiers in Immunology, 2021
Phagocytosis is a receptor-mediated process used by cells to engulf a wide variety of particulates, including microorganisms and apoptotic cells. Many of the proteins involved in this highly orchestrated process are post-translationally modified with ...
Charneal L. Dixon   +7 more
doaj   +1 more source

SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

open access: yeseLife, 2017
The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors. Understanding their regulation is thus important for studying biology and human diseases.
Xiaoyu Zhang   +4 more
doaj   +1 more source

Lipase catalysed kinetic resolution of racemic 1,2-diols containing a chiral quaternary center [PDF]

open access: yes, 2018
Optically active 1,2-diols are valuable buildings blocks in organic synthesis. In the present paper, a set of racemic 1,2-diols with an ester functional group are prepared, starting from -ketoesters in a three-step procedure with moderate yields.
Gonzalo Calvo, Gonzalo de
core   +2 more sources

ATP-independent Control of Vac8 Palmitoylation by a SNARE Subcomplex on Yeast Vacuoles [PDF]

open access: yes, 2005
Yeast vacuole fusion requires palmitoylated Vac8. We previously showed that Vac8 acylation occurs early in the fusion reaction, is blocked by antibodies against Sec18 (yeast N-ethylmaleimide-sensitive fusion protein (NSF)), and is mediated by the R-SNARE
Cristodero, Marina   +5 more
core   +1 more source

Acylation, a Conductor of Ghrelin Function in Brain Health and Disease

open access: yesFrontiers in Physiology, 2022
Acyl-ghrelin (AG) is an orexigenic hormone that has a unique octanoyl modification on its third serine residue. It is often referred to as the “hunger hormone” due to its involvement in stimulating food intake and regulating energy homeostasis.
Alanna S. Thomas   +4 more
doaj   +1 more source

Bi-acylation of cellulose: determining the relative reactivities of the acetyl and fatty-acyl moieties [PDF]

open access: yes, 2011
The global reaction between acetic anhydride and a fatty acid yields, at equilibrium, an asymmetric acetic-aliphatic anhydride in a medium containing finally: acetic-fatty anhydride, acetic anhydride, fatty acid, acetic acid and fatty anhydride.
Borredon, Marie-Elisabeth   +2 more
core   +2 more sources

Discovery of Anthocyanin Acyltransferase1 (AAT1) in Maize Using Genotyping-by-Sequencing (GBS)

open access: yesG3: Genes, Genomes, Genetics, 2018
The reduced acylation phenotype describes the inability of certain accessions of maize (Zea mays [L.]) to produce significant amounts of acylated anthocyanins, which are typically the most abundant pigments.
Michael N. Paulsmeyer   +2 more
doaj   +1 more source

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