Results 51 to 60 of about 98,046 (284)

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

Acyl Maleic Hydrazides as Versatile Acyl Transferring Agents. [PDF]

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Jadhav Latika Shivaji, Sabir H. Mashraqui   +1 more
openaire   +2 more sources

Designing New Natural‐Mimetic Phosphatidic Acid: A Versatile and Innovative Synthetic Strategy for Glycerophospholipid Research

Angewandte Chemie, EarlyView.
We report the role of the fatty acyl chains in biological activities of phosphatidic acids (PA). Several PA probes having two different fatty acyl chains were synthesized through a multi‐steps synthesis and bearing various fluorophores or photo‐cross‐linkers (PCL).
Antoine Schlichter, Alexander Wolf, Thomas Ferrand, Aurelien Cocq, Lina Riachy, Steven Vertueux, Brice Beauvais, Marine Courvalet, Paul‐Joël Henry, Emeline Tanguy, Louis Gonzales, Rémy Ferlet, Fanny Laguerre, Charles Decraene, Alexia Pellissier, Muriel Sebban, Cyrille Sabot, Lydie Jeandel, Sarah Cianférani, Jean‐Marc Strub, Magalie Bénard, Victor Flon, Valérie Peulon‐Agasse, Pascal Cardinael, Stéphane Ory, Stéphane Gasman, Pierre‐Yves Renard, Maïté Montero‐Hadjadje, Nicolas Vitale, Sébastien Balieu   +29 more
wiley   +2 more sources

Enhancing the β‐Oxidation‐Like Pathway for the Optimal Production of the Immunosuppressant Mycophenolic Acid

Advanced Science, EarlyView.
The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan, Yinuo Liu, Lu‐ping Chi, Chaofan Yang, Shengying Li, Wei Zhang   +5 more
wiley   +1 more source

Size‐Selective Functionalization of Sugars and Polyols Using Zeolites for Renewable Surfactant Production

Angewandte Chemie, EarlyView.
A zeolite‐catalyzed strategy enables size‐selective monoacetalization of sugars and polyols in a single step by leveraging pore confinement to distinguish between mono‐ and multi‐substituted species. This broadly applicable method avoids protection steps and excess reagents, opening new routes to bio‐based amphiphiles with strong surface activity and ...
Songlan Sun, Zezhong John Li, Yu‐Cheng Lin, Manon Rolland, Tom Nelis, Seongmin Jin, Shasha Zheng, Benjamin Nicolas Raffy, Wen Hua Bi, Esther Amstad, Jeremy S. Luterbacher   +10 more
wiley   +2 more sources

Catch and release’ cascades: a resin-mediated three-component cascade approach to small molecules [PDF]

, 2006
The application of a ‘catch and release’ approach to palladium-catalysed multi-component cascade reactions leads to diverse libraries of pharmacologically interesting small molecules in high yield and with excellent ...
Andrew Cook, Bannwarth, Baxter, Brain, Brown, De Luca, Dondas, Gai, Graybill, Grigg, Hoekstra, Kumpathy, Laganis, Larsen, Lee, Ley, Mason, Porcheddu, Ronald Grigg, Sui, Sumiyoshi, Thompson, Thompson, Wu   +23 more
core   +1 more source

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

VANILLYL-ACYL AMIDES. [PDF]

Journal of the American Chemical Society, 1919
n ...
openaire   +3 more sources

Transition Metal‐Free Formal C─H/C─H Coupling of Arylacetamides and Sulfoxides: An Interrupted Pummerer/[2,3]‐sigmatropic Rearrangement Sequence

Angewandte Chemie, EarlyView.
A two‐step formal C─H/C─H coupling of arylacetamides with sulfoxides proceeds via the formation and rearrangement of little‐known α‐amido sulfonium salts and provides an alternative to transition metal‐catalyzed C─H activation. The protocol is showcased in a short synthesis of a dopamine D1 receptor allosteric modulator.
Shibo Zhang, Ying Xin Lou, Allya Larroza, Ben W. Joynson, Ciro Romano, David J. Procter   +5 more
wiley   +2 more sources

HiTRACE-Web: an online tool for robust analysis of high-throughput capillary electrophoresis [PDF]

, 2013
To facilitate the analysis of large-scale high-throughput capillary electrophoresis data, we previously proposed a suite of efficient analysis software named HiTRACE (High Throughput Robust Analysis of Capillary Electrophoresis).
Cordero, Pablo, Das, Rhiju, Kim, Hanjoo, Yoon, Sungroh   +3 more
core   +2 more sources