Results 21 to 30 of about 10,400 (184)
Progress in Lipid Research, 2010 l-carnitine is present in mammalian cells as free carnitine and acylcarnitines. The acylcarnitine profile has been shown to be useful in identifying inborn errors of metabolism and to be altered under different metabolic conditions. While carnitine's most widely known function is its involvement in beta-oxidation of fatty acids, it may also have other ...
Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, United States ( host institution ) +3 more
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Synthesis of unsaturated carnitine esters with N-acyl imidazoles
Journal of Lipid Research, 1982 A novel procedure is described for the synthesis of acylcarnitines. This entails the synthesis of an N-acyl imidazole intermediate, which subsequently is reacted with L-carnitine perchlorate to form the acylcarnitine.
J Cervenka, H Osmundsen
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Metabolites, 2022 The objective of this study was to evaluate how schizophrenia spectrum disorders and applied long-term (5.1 years) antipsychotic (AP) treatment affect the serum level of acylcarnitines (ACs), cytokines and metabolic biomarkers and to characterize the ...
Madis Parksepp +6 more
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Acylcarnitine profiling by low-resolution LC-MS.
PLoS ONE, 2019 Acylcarnitines are fatty acyl esters of L-carnitine and facilitate the entry of long-chain fatty acids into mitochondria via the carnitine shuttle, where they are metabolized via ß-oxidation.
David Meierhofer
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Obesity and lipid stress inhibit carnitine acetyltransferase activity[S]
Journal of Lipid Research, 2014 Carnitine acetyltransferase (CrAT) is a mitochondrial matrix enzyme that catalyzes the interconversion of acetyl-CoA and acetylcarnitine. Emerging evidence suggests that this enzyme functions as a positive regulator of total body glucose tolerance and ...
Sarah E. Seiler +9 more
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Metabolites, 2021 Defects in fatty acid (FA) utilization have been well described in group 1 pulmonary hypertension (PH) and in heart failure (HF), yet poorly studied in group 2 PH.
Maxime Tremblay-Gravel +11 more
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Acylcarnitines: Distinguishing acylcarnitine isomeric forms by HPLC/ESI/MS
The FASEB Journal, 2006 Isomeric acylcarnitines are indistinguishable by tandem mass spectrometry. This methodological deficiency can be overcome by including a chromatographic component in the analysis procedure. Isomeric acylcarnitines were synthesized and their pentafluorophenacyl esters chromatographed by HPLC and detected by ESI/MS using a quadrupole ion‐trap instrument.
Paul E. Minkler +4 more
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Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells
Frontiers in Pharmacology, 2018 Impairment of hepatic fatty acid metabolism can lead to liver steatosis and injury. Testing drugs for interference with hepatic fatty acid metabolism is therefore important.
David Grünig +6 more
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Urine Metabolism Biomarkers Predict Preterm Infant Adiposity at Hospital Discharge. [PDF]
Mol Nutr Food ResIn this cohort of term and preterm infants, urinary amino acid and acylcarnitine concentrations varied by diabetes in pregnancy exposure and gestational age at birth, and certain patterns of urinary metabolites were differentially related to postnatal adiposity development in preterm infants of women with diabetes in pregnancy. ABSTRACT In infants born
Buck CO +5 more
europepmc +2 more sources
Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
Metabolites, 2023 Gaining a deep understanding of the molecular mechanisms underlying ischemic stroke is necessary to develop treatment alternatives. Ischemic stroke is known to cause a cellular energy imbalance when glucose supply is deprived, enhancing the role for ...
Leonidas Mavroudakis, Ingela Lanekoff
doaj +1 more source