Results 31 to 40 of about 10,400 (184)

Quantitative acylcarnitine determination by UHPLC-MS/MS — Going beyond tandem MS acylcarnitine “profiles” [PDF]

Molecular Genetics and Metabolism, 2015
Tandem MS "profiling" of acylcarnitines and amino acids was conceived as a first-tier screening method, and its application to expanded newborn screening has been enormously successful. However, unlike amino acid screening (which uses amino acid analysis as its second-tier validation of screening results), acylcarnitine "profiling" also assumed the ...
Paul E, Minkler, Maria S K, Stoll, Stephen T, Ingalls, Janos, Kerner, Charles L, Hoppel   +4 more
openaire   +2 more sources

Serum Acylcarnitines and Risk of Cardiovascular Death and Acute Myocardial Infarction in Patients With Stable Angina Pectoris

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundExcess levels of serum acylcarnitines, which are intermediate products in metabolism, have been observed in metabolic diseases such as type 2 diabetes mellitus.
Elin Strand, Eva R. Pedersen, Gard F. T. Svingen, Thomas Olsen, Bodil Bjørndal, Therese Karlsson, Jutta Dierkes, Pål R. Njølstad, Gunnar Mellgren, Grethe S. Tell, Rolf K. Berge, Asbjørn Svardal, Ottar Nygård   +12 more
doaj   +1 more source

The metabolomics approach revealed a distinctive metabolomics pattern associated with hyperthyroidism treatment

Frontiers in Endocrinology, 2022
BackgroundHyperthyroidism is characterized by increased thyroid hormone production, which impacts various processes, including metabolism and energy expenditure.
Malak A. Jaber, Hicham Benabdelkamel, Lina A. Dahabiyeh, Afshan Masood, Reem H. AlMalki, Reem H. AlMalki, Mohthash Musambil, Assim A. Alfadda, Assim A. Alfadda, Anas M. Abdel Rahman, Anas M. Abdel Rahman, Anas M. Abdel Rahman   +11 more
doaj   +1 more source

Simultaneously quantifying hundreds of acylcarnitines in multiple biological matrices within ten minutes using ultrahigh-performance liquid-chromatography and tandem mass spectrometry

Journal of Pharmaceutical Analysis
Acylcarnitines are metabolic intermediates of fatty acids and branched-chain amino acids having vital biofunctions and pathophysiological significances.
Jingxian Zhang, Qinsheng Chen, Lianglong Zhang, Biru Shi, Men Yu, Qingxia Huang, Huiru Tang   +6 more
doaj   +1 more source

Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada)

International Journal of Circumpolar Health, 2021
In contrast to most Indigenous people in Canada, Inuit appeared until recently to have been protected from type 2 diabetes (T2D) related to obesity. We assessed the associations of metabolites (amino acids, acylcarnitines) with adiposity and biomarkers ...
Thierry Comlan Marc Medehouenou, Cynthia Roy, Pierre-Yves Tremblay, Audray St-Jean, Salma Meziou, Gina Muckle, Pierre Ayotte, Michel Lucas   +7 more
doaj   +1 more source

A Preliminary Metabolomic Study of Yorkshire Terrier Enteropathy

Metabolites, 2022
Perturbations of metabolite profiles in human and canine enteropathies have been reported before. However, data in dogs are scarce and inconsistent. Currently, the metabolite profile in Yorkshire Terrier enteropathy (YTE) and the impact of treatment is ...
Alexandra I. Galler, Kristaps Klavins, Iwan A. Burgener   +2 more
doaj   +1 more source

Population-Level Analysis to Determine Parameters That Drive Variation in the Plasma Metabolite Profiles

Metabolites, 2018
The plasma metabolome is associated with multiple phenotypes and diseases. However, a systematic study investigating clinical determinants that control the metabolome has not yet been conducted.
Mahmoud Al-Majdoub, Katharina Herzog, Bledar Daka, Martin Magnusson, Lennart Råstam, Ulf Lindblad, Peter Spégel   +6 more
doaj   +1 more source

Insight into the metabolic shifts in Graves' hyperthyroidism: a study of acylcarnitine and lipid profiles

European Thyroid Journal
Objective: Graves' disease increases metabolism and leads to net lipid degradation. Circulating acylcarnitines reflect lipid metabolism and the state of fatty acid oxidation in individuals. The aim of this study was to explore the lipid and acylcarnitine
Mikael Thomassen Neset, Arve Ulvik, Kristian Løvås, Johnny Laupsa-Borge, Lars Ertesvåg Breivik, Ann-Elin Meling Stokland, Bjørn Gunnar Nedrebø, Eyvind Rødahl, Eystein Husebye, Grethe Åstrøm Ueland, Hans Olav Ueland   +10 more
doaj   +1 more source

A preliminary investigation of amino acid and acylcarnitine levels in neonates from the Tibet autonomous

Frontiers in Genetics, 2022
Background: The purpose of the study was to investigate the levels of amino acids and acylcarnitines in newborns of the Tibet Autonomous Region for the first time and to provide an experimental basis for the diagnosis of genetic metabolic diseases ...
Chunyan Zhang, Drun Dha, Yuxuan Cheng, Ya Ma, Yan Meng, Drun Tse, Dolma Ngawang, Pedrun Dekyi, Tao Jiang, Yang Shu, Jiayi Cui, Jing Li, Yaping Tian   +12 more
doaj   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source