Effects of Cannabidiol on TAFAZZIN‐Deficient B‐Lymphoblastoid Cells
Deficiency of the cardiolipin remodeling enzyme TAFAZZIN causes Barth syndrome (BTHS), resulting in cardiolipin loss, monolysocardiolipin (MLCL) accumulation, and electron transport chain (ETC) abnormalities in B‐lymphoblastoid cells. Effects of the non‐psychotropic phytocannabinoid cannabidiol (CBD) were examined on B‐lymphoblastoid cells from ...
John Z. Chan +10 more
wiley +1 more source
Lysophosphatidylcholine Acyltransferase 1-Phosphatidylcholine Axis Protects Nucleus Pulposus Cells From Ferroptosis by Facilitating Lysosomal Repair via Interaction With the Endoplasmic Reticulum. [PDF]
Li C +5 more
europepmc +1 more source
Characterization of <i>PDAT</i> Genes in Oat (<i>Avena sativa</i> L.) and the Role of <i>AsPDAT-5C</i> in Lipid Biosynthesis and Abiotic Stress Response. [PDF]
Sun Y +8 more
europepmc +1 more source
Genome-wide analysis of the <i>GPAT</i> gene family in wheat and the potential roles of <i>TaGPAT58</i> and its homologs in male reproductive development. [PDF]
Zhou H +7 more
europepmc +1 more source
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao +5 more
wiley +1 more source
Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang +12 more
wiley +1 more source
Comparative Expression of Diacylglycerol Acyltransferases for Enhanced Accumulation of Punicic Acid-Enriched Triacylglycerols in Yarrowia lipolytica. [PDF]
Hambalko V +5 more
europepmc +1 more source
Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice
A[Color figure can be viewed at www.annalsofneurology.org] Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone
Soudabeh Naderi +10 more
wiley +1 more source

