Results 11 to 20 of about 12,137 (168)

ADAMTS-1 Expression in Cumulus Cells: A Biomarker for Oocyte Maturity [PDF]

پزشکی بالینی ابن سینا, 2018
Background and Objective: Cumulus cells regulate oocyte maturation through bilateral communication during follicular growth. Expression of disintegrin-like and metalloproteinase with thrombospondin type I motifs-1 (ADAMTS-1) is essential for structural ...
Sepide Gohari Taban, Iraj Amiri, Massoud Saidijam, Sara Soleimani Asl, Mahnaz Yavangi, Elham Khanlarzadeh, Tayebe Artimani   +6 more
doaj   +2 more sources

Role of Versican and ADAMTS-1 in Polycystic Ovary Syndrome. [PDF]

J Clin Res Pediatr Endocrinol, 2017
ADAMTS-1 is a matrix metalloproteinase which cleaves versican in the cumulus oocyte complex under the effect of luteinizing hormone surge in the periovulatory period. Altered levels may have a role in the pathogenesis of polycystic ovary syndrome (PCOS).
Özler S, Öztaş E, Tokmak A, Ergin M, Kuru Pekcan M, Gümüş Güler B, Yakut Hİ, Yılmaz N.   +7 more
europepmc   +4 more sources

Role of adamts-1 in pleomorphic xanthoastrocytoma tumor cells progression [PDF]

Turkish Neurosurgery, 2021
To analyze the expression of ADAMTS-1, NF-?B, and STAT3 in human pleomorphic xanthoastrocytoma specimens, and their correlation with glioma advancement.Pleomorphic xanthoastrocytoma tumor cell lines were treated with low and high doses of cytokines at 24 and 48 hours (h) to replicate the inflammatory environment.
Gokce, Aysun, SUNGUROĞLU, Asuman, Gokce, Emre Cemal   +2 more
openaire   +3 more sources

Follicular ADAMTS-1 and aggrecan levels in polycystic ovary syndrome. [PDF]

J Assist Reprod Genet, 2017
Polycystic ovary syndrome (PCOS) is the most common cause of ovulatory dysfunction and female infertility. The etiopathogenetic mechanisms of PCOS have been studied for many years, although exact causes remain unclear. It has been demonstrated that proteoglycan degradation by a disintegrin-like metalloproteinase with thrombospondin type motifs-1 ...
Tola EN, Karatopuk DU, Koroglu N, Ergin M, Oral HB.   +4 more
europepmc   +7 more sources

ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis. [PDF]

J Cell Sci, 2020
ABSTRACT ADAMTS-1 is an extracellular protease with critical roles in organogenesis and angiogenesis. Here we demonstrate a functional convergence of ADAMTS-1 and the transmembrane heparan sulfate proteoglycan syndecan-4 in influencing adhesion, migration and angiogenesis.
Lambert J, Makin K, Akbareian S, Johnson R, Alghamdi AAA, Alghamdi AAA, Robinson SD, Edwards DR.   +7 more
europepmc   +6 more sources

Association of ADAMTS proteoglycanases downregulation with IVF-ET outcomes in patients with polycystic ovary syndrome: a systematic review and meta-analysis

Reproductive Biology and Endocrinology, 2022
Background A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) is involved in inflammation and fertility in women with polycystic ovary syndrome (PCOS).
Yanbin Shi, Yang Shi, Guiyuan He, Guang Wang, Hongbo Liu, Xiaoguang Shao   +5 more
doaj   +1 more source

Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling. [PDF]

Int J Mol Med
Skeletal muscle satellite cells (MuSCs) play a central role in muscle regeneration; however, their capacity declines with age, contributing to sarcopenia. A disintegrin and metalloproteinase with thrombospondin motifs‑1 (ADAMTS‑1) regulates MuSC activation and differentiation. The present study aimed to investigate the potential of recombinant ADAMTS‑1
Kim JH, Lee SH, Kim SY, Kim JW, Jeong JS, Chung EH, Lee SH, Kim CY, Choi BK, Ko JW, Kim TW.   +10 more
europepmc   +3 more sources

ADAMTS‐1 cleaves a cartilage proteoglycan, aggrecan [PDF]

FEBS Letters, 2000
A disintegrin‐like and metalloproteinase with thrombospondin type I motifs‐1 (ADAMTS‐1) is an extracellular matrix‐anchored metalloproteinase. In this study we have demonstrated that ADAMTS‐1 is able to cleave a major cartilage proteoglycan, aggrecan.
Kuno, Kouji, Okada, Yasunori, Kawashima, Hiroto, Nakamura, Hiroyuki, Miyasaka, Masayuki, Ohno, Hiroshi, Matsushima, Kouji   +6 more
openaire   +2 more sources

ADAMTS expression in colorectal cancer. [PDF]

PLoS ONE, 2015
ADAMTSs are a family of secreted proteinases that share the metalloproteinase domain with matrix metalloproteinases (MMPs). By acting on a large panel of extracellular substrates, they control several cell functions such as fusion, adhesion ...
Serafula Filou, Aggeliki Korpetinou, Dora Kyriakopoulou, Dimitrios Bounias, Michael Stavropoulos, Panagiota Ravazoula, Dionysios J Papachristou, Achilleas D Theocharis, Demitrios H Vynios   +8 more
doaj   +1 more source

First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator

Diagnostics, 2022
Background: We have previously shown that metzincin protease ADAMTS-4 accompanies renal fibrogenesis, as it appears in the blood of hemodialysis patients.
Ivana Kovacevic Vojtusek, Mario Laganovic, Marija Burek Kamenaric, Stela Bulimbasic, Stela Hrkac, Grgur Salai, Vanja Ivkovic, Marijana Coric, Rudjer Novak, Lovorka Grgurevic   +9 more
doaj   +1 more source