Results 31 to 40 of about 12,137 (168)

ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia

Hypertension in Pregnancy, 2018
The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies.
Müberra Namlı Kalem, Ziya Kalem, Tuncay Yüce, Feride Soylemez   +3 more
doaj   +1 more source

ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis

Frontiers in Cardiovascular Medicine, 2020
Background: Acute aortic dissection (AAD) is associated with degeneration of the aortic media and accompanied by vascular extracellular matrix (ECM) remodeling.
Tao Zeng, Jianting Gan, Yu Liu, Lei Shi, Zhengde Lu, Yan Xue, Rixin Xiong, Ling Liu, Zicong Yang, Yingzhong Lin, Jun Yuan   +10 more
doaj   +1 more source

Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women

Акушерство, гинекология и репродукция, 2023
Introduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel–Palade bodies, which can affect activity of ADAMTS ...
N. R. Gashimova, K. N. Grigoreva, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, Ya. M. Shammut, E. Iu. Iupatov, V. I. Tsibizova, J.-K. Gris, D. V. Blinov, A. D. Makatsariya   +11 more
doaj   +1 more source

Selective inhibition of ADAMTS‐1, ‐4 and ‐5 by catechin gallate esters [PDF]

European Journal of Biochemistry, 2003
Three mammalian ADAMTS enzymes, ADAMTS‐1, ‐4 and ‐5, are known to cleave aggrecan at certain glutamyl bonds and are considered to be largely responsible for cartilage aggrecan catabolism observed during the development of arthritis. We have previously reported that certain catechins, polyphenolic compounds found in highest concentration in green tea ...
Day, A. J., Knight, C. Graham., Mort, John S., Buttle, D. J., Vankemmelbeke, Mireille N., Jones, G. C., Fowles, C., Ilic, Mirna., Handley, Christopher.   +8 more
openaire   +2 more sources

ADAMTS-15 Has a Tumor Suppressor Role in Prostate Cancer

Biomolecules, 2020
Extracellular matrix remodeling has emerged as an important factor in many cancers. Proteoglycans, including versican (VCAN), are regulated via cleavage by the proteolytic actions of A Disintegrin-like And Metalloproteinase domain with Thrombospondin-1 ...
Marley J. Binder, Scott McCoombe, Elizabeth D. Williams, Daniel R. McCulloch, Alister C. Ward   +4 more
doaj   +1 more source

The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. [PDF]

PLoS ONE, 2015
The specific degradation of type II collagen and aggrecan by matrix metalloproteinase (MMP)-9, -13 and ADAMTS-4 and -5 (aggrecanase-1 and -2) in the cartilage matrix is a critical step in pathology of osteoarthritis (OA).
Yi He, Qinlong Zheng, MengMeng Jiang, Shu Sun, Thorbjørn G Christiansen, Moustapha Kassem, Morten A Karsdal, Anne C Bay-Jensen   +7 more
doaj   +1 more source

ADAMTS-13 activity in stroke of known and unknown cause: Relation to vascular risk factor burden

Frontiers in Neurology, 2023
BackgroundThe identification of the underlying mechanism in ischemic stroke has important implications for secondary prevention. A disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS-13) has antithrombotic properties and
Gerrit M. Grosse, Andrei Leotescu, Jan-Thorben Sieweke, Sonja Schneppenheim, Ulrich Budde, Nora L. Ziegler, Saskia Biber, Maria M. Gabriel, Johanna Ernst, Ramona Schuppner, Ralf Lichtinghagen, Udo Bavendiek, Julian Widder, Julian Widder, Karin Weissenborn   +14 more
doaj   +1 more source

Coordinate Transcription of the ADAMTS-1 Gene by Luteinizing Hormone and Progesterone Receptor [PDF]

Molecular Endocrinology, 2004
AbstractADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin-like motifs) is a multifunctional protease that is expressed in periovulatory follicles. Herein we show that induction of ADAMTS-1 message in vivo and transcription of the ADAMTS-1 promoter in cultured granulosa cells are dependent on separable but coordinate actions of LH and ...
Doyle, K., Russell, D., Sriraman, V., Richards, J.   +3 more
openaire   +3 more sources

Adventitial delivery of lentivirus-shRNA-ADAMTS-1 reduces venous stenosis formation in arteriovenous fistula.

PLoS ONE, 2014
Hemodialysis vascular access can develop venous neointimal hyperplasia (VNH) causing stenosis. Recent clinical and experimental data has demonstrated that there is increased expression of a disintegrin and metalloproteinase thrombospondin motifs-1 ...
Evelyn C Nieves Torres, Binxia Yang, Bhaskar Roy, Rajiv Janardhanan, Akshaar Brahmbhatt, Ed Leof, Debabrata Mukhopadhyay, Sanjay Misra   +7 more
doaj   +1 more source

Immunothrombosis in cancer patients: contribution of neutrophil extracellular traps, ADAMTS-13 and von Willebrand factor

Акушерство, гинекология и репродукция, 2023
Introduction. Neutrophil extracellular traps (NETs) and von Willebrand factor (vWF) are integral players in thrombosis and inflammation in cancer patients. It has been increasingly evident that an active interplay exists between NETs and vWF.
E. V. Slukhanchuk, V. O. Bitsadze, A. G. Solopova, J. Kh. Khizroeva, V. I. Tsibizova, J.-K. Gris, I. Elalamy, D. V. Shcherbakov, L. L. Pankratyeva, L. A. Ashrafyan, A. D. Makatsariya   +10 more
doaj   +1 more source