Results 51 to 60 of about 380 (133)

RELATIONSHIP OF ADAMTS WITH BIOCHEMICAL PARAMETERS IN METABOLIC SYNDROME

Sabiad
Objective: The aim of our study was to investigate the potential of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) proteins, which are thought to change in levels as a result of the deterioration of the extracellular matrix in ...
Semiramis Doğan Zeybek, Adnan Adil Hişmioğulları   +1 more
doaj   +1 more source

ADAMTS-7 Expression Increases in the Early Stage of Angiotensin II-Induced Renal Injury in Elderly Mice

Kidney & Blood Pressure Research, 2014
Background/Aims: We investigated the recently described family of proteinases, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTs), and matrix metalloproteinases (MMPs) as inflammatory mediators in inflammatory kidney damage by ...
Yan-Xiang Gao, Chang-An Yu, Jian-Hua Lu, Hong-Mei Gao, Geng Li, Wei Kong, Jingang Zheng   +6 more
doaj   +1 more source

Histopathologic Analysis of the Morpho‐Functional Zones of the Human Acetabular Labrum

Clinical Anatomy, EarlyView.
ABSTRACT The structural and functional adaptation of soft tissues to mechanical load controls their ability to withstand injury and influences their capacity for healing. Similar to the knee meniscus, the acetabular labrum exhibits zonal differences in mechanical load distribution, resulting in distinct regions with unique structural and functional ...
Abdulaziz A. Alomiery, Andrew C. Hall, Thomas H. Gillingwater, Afaf Alsolami, Abduelmenem Alashkham   +4 more
wiley   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Licochalcone A Inhibits MMPs and ADAMTSs via the NF-κB and Wnt/β-Catenin Signaling Pathways in Rat Chondrocytes

Cellular Physiology and Biochemistry, 2017
Background: Osteoarthritis (OA) is a joint disease in which cartilage degradation is the central pathological change. In this study, we investigated the anti-osteoarthritic effects of licochalcone A (Lico A) in rat chondrocytes. Methods: Polymerase chain
Wei-Ping Chen, Zhong-Nan Hu, Li-Bin Jin, Li-Dong Wu   +3 more
doaj   +1 more source

A possible issue of articular cartilage degeneration in acute phase after anterior cruciate ligament reconstruction

Orthopaedic Journal of Sports Medicine, 2021
Objectives: Intra-articular hematoma are caused by articular injury such as ligament rupture or intra-articular fracture and following knee surgery. It has been reported that intra-articular hematoma leads to cartilage degeneration. Exposure of articular
Takuya Tajima MD, PhD, Nami Yamaguchi, Takuji Yokoe, Etsuo Chosa, Yudai Morita MD   +4 more
doaj   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion [PDF]

Molecular Cancer, 2013
ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in normal and neoplastic tissues using qPCR, immunohistochemistry and immunoblot analyses, and we addressed the role of ADAMTS-1 in regulating migration, invasion and ...
Freitas, Vanessa M, do Amaral, Jônatas Bussador, Silva, Thaiomara A, Santos, Emerson S, Mangone, Flávia R, Pinheiro, João de Jesus, Jaeger, Ruy G, Nagai, Maria A, Machado-Santelli, Gláucia Maria   +8 more
openaire   +2 more sources