Results 51 to 60 of about 12,137 (168)

Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases [PDF]

Proceedings of the National Academy of Sciences, 2000
Ovulation is a precisely timed process by which a mature oocyte is released from an ovarian follicle. This process is initiated by the pituitary surge of luteinizing hormone (LH), is temporally associated with transcriptional regulation of numerous genes, and is presumed to involve the synthesis and/or activation of specific proteases that degrade the ...
R L, Robker, D L, Russell, L L, Espey, J P, Lydon, B W, O'Malley, J S, Richards   +5 more
openaire   +2 more sources

Thrombotic thrombocytopenic purpura as a rare cause of anemia with thrombocytopenia in childhood: report of 2 cases

The Turkish Journal of Pediatrics, 2019
Thrombotic thrombocytopenic purpura (TTP) is a rare multisystem disorder characterized by single or recurrent episodes of thrombocytopenia, microangiopathic hemolytic anemia and widespread microvascular thrombosis, which causes significant morbidity and
Oya Köker, Zeynep Yıldız Yıldırmak, Dildar Bahar Genç, Önder Kılıçaslan   +3 more
doaj   +1 more source

ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals

Scientific Reports, 2023
This study investigated the cytotoxic effects of oxidative stress (OS), high mobility group box 1 (HMGB1), ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs), and neuropathology associated with coenurus cerebralis (Taenia multiceps).
Gungor Cagdas Dincel, Orhan Yavuz, Serkan Yildirim, Ebtesam M. Al-Olayan, Saeed El-Ashram   +4 more
doaj   +1 more source

Harnessing bacterial extracellular vesicles for bone and cartilage organoids

BMEMat, EarlyView.
This review presents bacterial extracellular vesicles (BEVs) as programmable bioactive regulators for bone and cartilage organoids by delivering functional cargos that modulate skeletal remodeling. It highlights key engineering strategies and future directions to advance next‐generation organoid models for bone aging related diseases.
Han Liu, Xukun Lv, Ting Cheng, Lei Yan, Yuxiao Lai, Keying Guo, Yingying Jing, Hao Shen, Jiacan Su   +8 more
wiley   +1 more source

RELATIONSHIP OF ADAMTS WITH BIOCHEMICAL PARAMETERS IN METABOLIC SYNDROME

Sabiad
Objective: The aim of our study was to investigate the potential of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) proteins, which are thought to change in levels as a result of the deterioration of the extracellular matrix in ...
Semiramis Doğan Zeybek, Adnan Adil Hişmioğulları   +1 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

ADAMTS-7 Expression Increases in the Early Stage of Angiotensin II-Induced Renal Injury in Elderly Mice

Kidney & Blood Pressure Research, 2014
Background/Aims: We investigated the recently described family of proteinases, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTs), and matrix metalloproteinases (MMPs) as inflammatory mediators in inflammatory kidney damage by ...
Yan-Xiang Gao, Chang-An Yu, Jian-Hua Lu, Hong-Mei Gao, Geng Li, Wei Kong, Jingang Zheng   +6 more
doaj   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion [PDF]

Molecular Cancer, 2013
ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in normal and neoplastic tissues using qPCR, immunohistochemistry and immunoblot analyses, and we addressed the role of ADAMTS-1 in regulating migration, invasion and ...
Freitas, Vanessa M, do Amaral, Jônatas Bussador, Silva, Thaiomara A, Santos, Emerson S, Mangone, Flávia R, Pinheiro, João de Jesus, Jaeger, Ruy G, Nagai, Maria A, Machado-Santelli, Gláucia Maria   +8 more
openaire   +2 more sources