Results 71 to 80 of about 12,137 (168)

Determination of vWF, ADAMTS-13 and Thrombospondin-1 in Venous Thromboembolism and Relating Them to the Presence of Factor V Leiden Mutation

Clinical and Applied Thrombosis/Hemostasis
Thrombophilia in venous thromboembolism (VTE) is multifactorial. Von Willebrand factor (vWF) plays a major role in primary hemostasis. While elevated vWF levels are well documented in VTE, findings related to its cleaving protease (ADAMTS-13) are ...
Anwar Al-Awadhi PhD, Rajaa Marouf MBBch, DCP, FRCPath, Mehrez M. Jadaon MS, Mohammad M. Al-Awadhy MD   +3 more
doaj   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

IMMUNOHISTOCHEMICAL ANALYSIS OF SFLT-1 AND ADAMTS-8 EXPRESSION IN DIABETIC RAT TESTIS TISSUE

International Journal of Health Services Research and Policy, 2019
he aim of this study was to determine the testicular inflammation and angiogenetic effect of diabetes with ADAMTS-8 and SFlt-1 proteins immunohistochemically.
Seval Kaya
doaj   +1 more source

USP25 stabilises GLI1 through K48‐linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
GLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Qian Zhang, Yinyan Ye, Yijie Huang, Jun Li, Dongfeng Huang   +4 more
wiley   +1 more source

Monitoring ADAMTS-13 conformation in immune-mediated thrombotic thrombocytopenic purpura: toward personalized management

Research and Practice in Thrombosis and Haemostasis
Background: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy caused by an autoimmune-driven deficiency of ADAMTS-13.
Bérangère S. Joly, Elien Roose, Charlotte Dekimpe, Karen Vanhoorelbeke, Agnès Veyradier, Paul Coppo   +5 more
doaj   +1 more source

ADAMTS-1 has nuclear localization in cells with epithelial origin and leads to decreased cell migration. [PDF]

Exp Cell Res, 2023
Silva SV, Lima MA, Hodgson L, Freitas VM, Rodríguez-Manzaneque JC.   +4 more
europepmc   +1 more source

Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis

Developmental Biology, 2006
Murine ovarian folliculogenesis commences after birth involving oocyte growth, somatic cell differentiation and structural remodeling of follicle stromal boundaries. The extracellular metalloproteinase ADAMTS-1 has activity against proteoglycans and collagen and is produced by the granulosa cells of ovarian follicles. Mice with ADAMTS-1 gene disruption
Brown, H., Dunning, K., Robker, R., Pritchard, M., Russell, D.   +4 more
openaire   +3 more sources

Assessment of ADAMTS-13 Level in Hospitalized Children with Serious Bacterial Infections as a Possible Prognostic Marker

Medicina, 2019
Background and objectives: In children, acute infection is the most common cause of visits in the primary care or emergency department. In 2002, criteria for diagnostics of pediatric sepsis were published, and then revised in 2016 as “life ...
Linda Rautiainen, Anna Cirko, Jana Pavare, Reinis Balmaks, Ilze Grope, Irina Katirlo, Gita Gersone, Peteris Tretjakovs, Dace Gardovska   +8 more
doaj   +1 more source

Mechanistic insight into multiple antibody binding to ADAMTS13 in immune thrombotic thrombocytopenic purpura

Research and Practice in Thrombosis and Haemostasis
Background: Antibody-mediated inhibition of von Willebrand factor (VWF) cleavage by ADAMTS-13 results in immune thrombotic thrombocytopenic purpura (iTTP).
Konstantine Halkidis, Chan Meng, Vikram G. Pillai, Madison Shay, Szumam Liu, X. Long Zheng   +5 more
doaj   +1 more source

Prognostic role of the vWF/ADAMTS-13 axis in thrombosis risk stratification in gynecologic oncology patients

Акушерство, гинекология и репродукция
Aim: to evaluate a prognostic significance for the vWF/ADAMTS-13 (von Willebrand factor/a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13) ratio as an integral biomarker for stratifying the risk of venous thromboembolic events
A. V. Vorobev, V. O. Bitsadze, A. G. Solopova, J. Kh. Khizroeva, D. O. Utkin, D. О. Ostrikov, D. V. Blinov, J.-C. Gris, I. Elalamy, G. Gerotziafas, A. D. Makatsariya   +10 more
doaj   +1 more source