Results 61 to 70 of about 380 (133)

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

The ADAMTS/Fibrillin Connection: Insights into the Biological Functions of ADAMTS10 and ADAMTS17 and Their Respective Sister Proteases

Biomolecules, 2020
Secreted a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS) proteases play crucial roles in tissue development and homeostasis.
Stylianos Z. Karoulias, Nandaraj Taye, Sarah Stanley, Dirk Hubmacher   +3 more
doaj   +1 more source

The High‐Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration

Orthopaedic Surgery, EarlyView.
The HIZ, a dynamic inflammatory hub in lumbar disc degeneration, links inflammation‐degeneration‐pain; integrating advanced diagnostics and targeted therapies offers precise management for discogenic low back pain. ABSTRACT The lumbar intervertebral disc high‐intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2‐weighted ...
Qi Zhou, Jingyi Cai, Weijian Zhu, Sirui Zhou, Liling Zhou, Yiyao Pei, Gang Wu   +6 more
wiley   +1 more source

Immunohistochemical analysis of ADAMTS-1, versican and pEGFR expressions in periapical granuloma and radicular cyst

BMC Oral Health, 2021
Background ADAMTS expression can be associated with several inflammatory processes, and has been correlated with tumorigenesis of some neoplasms, but its participation in the development of periapical lesions has not been investigated.
Nádia Marielly Gomes Batista, Antonia Taiane Lopes de Moraes, Karolyny Martins Balbinot, Osvaldo Rodrigues de Souza Neto, Juliana Melo da Silva Brandão, Maria Sueli da Silva kataoka, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro   +7 more
doaj   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Report on the 13th international workshop on the CCN family of genes and inaugural ARBIOCOM conference, Nice, France

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Celebration of the 13th ICCNS meeting joint to the 1st ARBIOCOM Conference held on the site of Nice in December 2025. Abstract The 13th International Workshop on the CCN Family of Genes, held in Nice as part of the inaugural ARBIOCOM World Conference, brought together investigators with diverse research backgrounds, disciplines, and expertise. Building
Bernard Perbal, Ralf Weiskirchen, Annick Perbal, Brahim Chaqour   +3 more
wiley   +1 more source

Causal association and mechanistic validation of the USP8‐DLK1 axis in osteoarthritis: A genetic meta‐analysis integrated with in vitro and in vivo investigations

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Abstract Background/Objective Osteoarthritis (OA) affects more than 500 million people globally and remains without effective disease‐modifying therapy, owing in part to an incomplete understanding of the molecular mechanisms driving chondrocyte degeneration.
Sayed Abdulla Jami, Md Ariful Haque, Ernest Dapaah, Vidmi Taolam Martin, Md Tofazzale Hosain   +4 more
wiley   +1 more source

Determination of vWF, ADAMTS-13 and Thrombospondin-1 in Venous Thromboembolism and Relating Them to the Presence of Factor V Leiden Mutation

Clinical and Applied Thrombosis/Hemostasis
Thrombophilia in venous thromboembolism (VTE) is multifactorial. Von Willebrand factor (vWF) plays a major role in primary hemostasis. While elevated vWF levels are well documented in VTE, findings related to its cleaving protease (ADAMTS-13) are ...
Anwar Al-Awadhi PhD, Rajaa Marouf MBBch, DCP, FRCPath, Mehrez M. Jadaon MS, Mohammad M. Al-Awadhy MD   +3 more
doaj   +1 more source

IMMUNOHISTOCHEMICAL ANALYSIS OF SFLT-1 AND ADAMTS-8 EXPRESSION IN DIABETIC RAT TESTIS TISSUE

International Journal of Health Services Research and Policy, 2019
he aim of this study was to determine the testicular inflammation and angiogenetic effect of diabetes with ADAMTS-8 and SFlt-1 proteins immunohistochemically.
Seval Kaya
doaj   +1 more source

ADAMTS4 mediates LPS‐induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
• ADAMTS4 is induced primarily in cardiac fibroblasts during sepsis. • ADAMTS4 cleaves TSP1 at the 236–246 aa functional region. • TSP1 cleavage activates TGF‐β/Smad and NF‐κB signalling in fibroblasts. • Targeting ADAMTS4 reduces fibroblast activation and cardiac fibrosis.
Zhe‐Wei Zhang, Shi‐Yan Wan, Wen Li, Xiao Lu, Rong Chen, Xin Xing, Wei Lai, Shu‐Yang Sheng, M. M. Mosebetsi, Qing‐Tao Meng, Zi‐Long Lu, Di Fan, Wan‐Li Jiang   +12 more
wiley   +1 more source