Results 21 to 30 of about 380 (133)

Follicular ADAMTS-1 and aggrecan levels in polycystic ovary syndrome [PDF]

Journal of Assisted Reproduction and Genetics, 2017
Polycystic ovary syndrome (PCOS) is the most common cause of ovulatory dysfunction and female infertility. The etiopathogenetic mechanisms of PCOS have been studied for many years, although exact causes remain unclear. It has been demonstrated that proteoglycan degradation by a disintegrin-like metalloproteinase with thrombospondin type motifs-1 ...
Koroglu, Nadiye, ORAL, Hilmi Baha, ERGİN, Merve, Tola, Esra Nur, Karatopuk, Dilek   +4 more
openaire   +5 more sources

Fibulin-1 Acts as a Cofactor for the Matrix Metalloprotease ADAMTS-1 [PDF]

Journal of Biological Chemistry, 2005
ADAMTS-1 is a metalloprotease that has been implicated in the inhibition of angiogenesis and is a mediator of proteolytic cleavage of the hyaluronan binding proteoglycans, aggrecan and versican. In an attempt to further understand the biological function of ADAMTS-1, a yeast two-hybrid screen was performed using the carboxyl-terminal region of ADAMTS-1
Nathan V, Lee, Juan Carlos, Rodriguez-Manzaneque, Shelley N-M, Thai, Waleed O, Twal, Alfonso, Luque, Karen M, Lyons, W Scott, Argraves, M Luisa, Iruela-Arispe   +7 more
openaire   +2 more sources

Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family.

PLoS Computational Biology, 2023
Numerous computational methods based on sequences or structures have been developed for the characterization of protein function, but they are still unsatisfactory to deal with the multiple functions of multi-domain protein families.
Olivier Dennler, François Coste, Samuel Blanquart, Catherine Belleannée, Nathalie Théret   +4 more
doaj   +1 more source

Role of Versican and ADAMTS-1 in Polycystic Ovary Syndrome

Journal of Clinical Research in Pediatric Endocrinology, 2017
ADAMTS-1 is a matrix metalloproteinase which cleaves versican in the cumulus oocyte complex under the effect of luteinizing hormone surge in the periovulatory period. Altered levels may have a role in the pathogenesis of polycystic ovary syndrome (PCOS).
Ergin, MERVE, Yılmaz, N, Yakut, Hİ, Gümüş, Güler, Kuru, Pekcan, Tokmak, A, Öztaş, E, Özler, S   +7 more
openaire   +3 more sources

ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis

Frontiers in Cardiovascular Medicine, 2020
Background: Acute aortic dissection (AAD) is associated with degeneration of the aortic media and accompanied by vascular extracellular matrix (ECM) remodeling.
Tao Zeng, Jianting Gan, Yu Liu, Lei Shi, Zhengde Lu, Yan Xue, Rixin Xiong, Ling Liu, Zicong Yang, Yingzhong Lin, Jun Yuan   +10 more
doaj   +1 more source

ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia

Hypertension in Pregnancy, 2018
The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies.
Müberra Namlı Kalem, Ziya Kalem, Tuncay Yüce, Feride Soylemez   +3 more
doaj   +1 more source

Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model

Intensive Care Medicine Experimental, 2020
Introduction In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, resulting in obstruction of the microcirculation and ...
Mathijs R. Wirtz, Daan P. van den Brink, Joris J. T. H. Roelofs, J. Carel Goslings, Nicole P. Juffermans   +4 more
doaj   +1 more source

Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women

Акушерство, гинекология и репродукция, 2023
Introduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel–Palade bodies, which can affect activity of ADAMTS ...
N. R. Gashimova, K. N. Grigoreva, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, Ya. M. Shammut, E. Iu. Iupatov, V. I. Tsibizova, J.-K. Gris, D. V. Blinov, A. D. Makatsariya   +11 more
doaj   +1 more source

Selective inhibition of ADAMTS‐1, ‐4 and ‐5 by catechin gallate esters [PDF]

European Journal of Biochemistry, 2003
Three mammalian ADAMTS enzymes, ADAMTS‐1, ‐4 and ‐5, are known to cleave aggrecan at certain glutamyl bonds and are considered to be largely responsible for cartilage aggrecan catabolism observed during the development of arthritis. We have previously reported that certain catechins, polyphenolic compounds found in highest concentration in green tea ...
Day, A. J., Knight, C. Graham., Mort, John S., Buttle, D. J., Vankemmelbeke, Mireille N., Jones, G. C., Fowles, C., Ilic, Mirna., Handley, Christopher.   +8 more
openaire   +2 more sources

ADAMTS-15 Has a Tumor Suppressor Role in Prostate Cancer

Biomolecules, 2020
Extracellular matrix remodeling has emerged as an important factor in many cancers. Proteoglycans, including versican (VCAN), are regulated via cleavage by the proteolytic actions of A Disintegrin-like And Metalloproteinase domain with Thrombospondin-1 ...
Marley J. Binder, Scott McCoombe, Elizabeth D. Williams, Daniel R. McCulloch, Alister C. Ward   +4 more
doaj   +1 more source