Results 21 to 30 of about 12,137 (168)

Is There a Role of ADAMTS-1 in Cyst Development in Autosomal Dominant Polycystic Kidney Disease?

Turkish Journal of Nephrology, 2021
Objective: Autosomal dominant polycystic kidney disease (ADPKD) is the most commonly inherited kidney disease. It is characterized by the development of multiple bilateral cysts that cause enlargement of the kidney. The underlying mechanisms related with
Süleyman Karaköse, Pervin Özkan Kurtgöz, Çiğdem Damla Deniz, Edip Erkuş, İbrahim Güney   +4 more
doaj   +1 more source

ADAMTS-1 Is an Active Metalloproteinase Associated with the Extracellular Matrix [PDF]

Journal of Biological Chemistry, 1999
Cellular disintegrin and metalloproteinases (ADAMs) are a family of genes with a sequence similar to the snake venom metalloproteinases and disintegrins. ADAMTS-1 is a unique ADAM family protein with respect to the presence of thrombospondin type I motifs and the capacity to bind to the extracellular matrix.
K, Kuno, Y, Terashima, K, Matsushima
openaire   +2 more sources

Identification of Prodomain Determinants Involved in ADAMTS-1 Biosynthesis [PDF]

Journal of Biological Chemistry, 2004
The metalloprotease ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin type I motif), similarly to other members of the ADAMTS family, is initially synthesized as a zymogen, proADAMTS-1, that undergoes proteolytic processing at the prodomain/catalytic domain junction by serine proteinases of the furin-like family of proprotein convertases.
Jean-Michel, Longpré, Richard, Leduc
openaire   +2 more sources

ADAMTS proteases in cardiovascular physiology and disease [PDF]

Open Biology, 2020
The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family comprises 19 proteases that regulate the structure and function of extracellular proteins in the extracellular matrix and blood.
Salvatore Santamaria, Rens de Groot
doaj   +1 more source

The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis

Biomolecules, 2022
Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized by the inflammation of the bone leading to degeneration and loss of cartilage function.
Ting Li, Jie Peng, Qingqing Li, Yuan Shu, Peijun Zhu, Liang Hao   +5 more
doaj   +1 more source

Gene expression and immunohistochemistry analysis of ADAMTS-1 and its substrates in odontogenic keratocyst. [PDF]

Diagn Pathol
Considering the significant participation of the microenvironment in the local aggressiveness of odontogenic keratocysts, this study aims to evaluate the expression of ADAMTS-1 and its substrates, versican, aggrecan and brevican in this locally invasive odontogenic cyst.Immunohistochemistry and polymerase chain reaction (PCR) were conducted on 30 cases
de Souza Neto OR, de Moraes ATL, Fuzii HT, Maneschy Faria AG, Freitas VM, da Silva Kataoka MS, de Melo Alves S, de Jesus Viana Pinheiro J.   +7 more
europepmc   +4 more sources

Differential Effects of ADAMTS-1, -4, and -5 in the Trabecular Meshwork [PDF]

Investigative Opthalmology & Visual Science, 2009
Matrix metalloproteinases (MMPs) degrade extracellular matrix (ECM) and increase outflow facility in anterior segment perfusion culture. One group is the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin type 1 motifs). In this study, the authors examined the effects of ADAMTS-1, -4, and -5 on outflow facility and investigated their mRNA
Kate E, Keller, John M, Bradley, Ted S, Acott   +2 more
openaire   +2 more sources

Fibulin-1 Acts as a Cofactor for the Matrix Metalloprotease ADAMTS-1 [PDF]

Journal of Biological Chemistry, 2005
ADAMTS-1 is a metalloprotease that has been implicated in the inhibition of angiogenesis and is a mediator of proteolytic cleavage of the hyaluronan binding proteoglycans, aggrecan and versican. In an attempt to further understand the biological function of ADAMTS-1, a yeast two-hybrid screen was performed using the carboxyl-terminal region of ADAMTS-1
Nathan V, Lee, Juan Carlos, Rodriguez-Manzaneque, Shelley N-M, Thai, Waleed O, Twal, Alfonso, Luque, Karen M, Lyons, W Scott, Argraves, M Luisa, Iruela-Arispe   +7 more
openaire   +2 more sources

Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family.

PLoS Computational Biology, 2023
Numerous computational methods based on sequences or structures have been developed for the characterization of protein function, but they are still unsatisfactory to deal with the multiple functions of multi-domain protein families.
Olivier Dennler, François Coste, Samuel Blanquart, Catherine Belleannée, Nathalie Théret   +4 more
doaj   +1 more source

Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model

Intensive Care Medicine Experimental, 2020
Introduction In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, resulting in obstruction of the microcirculation and ...
Mathijs R. Wirtz, Daan P. van den Brink, Joris J. T. H. Roelofs, J. Carel Goslings, Nicole P. Juffermans   +4 more
doaj   +1 more source