Results 61 to 70 of about 11,949 (172)

The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury

Journal of Neuroinflammation, 2012
Background Chondroitin sulfate proteoglycans are major inhibitory molecules for neural plasticity under both physiological and pathological conditions. The chondroitin sulfate degrading enzyme chondroitinase ABC promotes functional recovery after spinal ...
Tauchi Ryoji, Imagama Shiro, Natori Takamitsu, Ohgomori Tomohiro, Muramoto Akio, Shinjo Ryuichi, Matsuyama Yukihiro, Ishiguro Naoki, Kadomatsu Kenji   +8 more
doaj   +1 more source

Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators. [PDF]

PLoS ONE, 2012
The extracellular signaling protein Reelin, indispensable for proper neuronal migration and cortical layering during development, is also expressed in the adult brain where it modulates synaptic functions. It has been shown that proteolytic processing of
Dimitrije Krstic, Myriam Rodriguez, Irene Knuesel   +2 more
doaj   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes [PDF]

Arthritis Research & Therapy, 2013
Abstract Introduction Increased expression of aggrecanase-1 (ADAMTS-4) has emerged as an important factor in osteoarthritis (OA) and other joint diseases. This study aimed to determine whether the expression of ADAMTS-4 in human chondrocytes is regulated by miRNA.
Matsukawa, Tetsuya, Sakai, Tadahiro, Yonezawa, Tomo, Hiraiwa, Hideki, Hamada, Takashi, Nakashima, Motoshige, Ono, Yohei, Ishizuka, Shinya, Nakahara, Hiroyuki, Lotz, Martin K, Asahara, Hiroshi, Ishiguro, Naoki   +11 more
openaire   +2 more sources

Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells [PDF]

European Cells & Materials, 2012
Aggrecanases from the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family are important therapeutic targets due to their essential role in aggrecan depletion in arthritic diseases.
W Richter, B Moradi, CB Little, J Fischer, S Boeuf, F Graf   +5 more
doaj  

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5 [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2009
Cleavage of aggrecan by ADAMTS proteinases at specific sites within highly conserved regions may be important to normal physiological enzyme functions, as well as pathological degradation.To examine ADAMTS selectivity, we assayed ADAMTS-4 and -5 cleavage of recombinant bovine aggrecan mutated at amino acids N-terminal or C-terminal to the interglobular
Hazuki E, Miwa, Thomas A, Gerken, Tru D, Huynh, Lori R, Duesler, Meghan, Cotter, Thomas M, Hering   +5 more
openaire   +2 more sources

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Autocatalytic Cleavage of ADAMTS-4 (Aggrecanase-1) Reveals Multiple Glycosaminoglycan-binding Sites [PDF]

Journal of Biological Chemistry, 2002
ADAMTS-4, also referred to as aggrecanase-1, is a glutamyl endopeptidase capable of generating catabolic fragments of aggrecan analogous to those released from articular cartilage during degenerative joint diseases such as osteoarthritis. Efficient aggrecanase activity requires the presence of sulfated glycosaminoglycans (GAGs) attached to the aggrecan
Carl R, Flannery, Weilan, Zeng, Chris, Corcoran, Lisa A, Collins-Racie, Priya S, Chockalingam, Tracy, Hebert, Stewart A, Mackie, Thomas, McDonagh, Tara K, Crawford, Kathy N, Tomkinson, Edward R, LaVallie, Elisabeth A, Morris   +11 more
openaire   +2 more sources

Gene Expression of Metalloproteinases and Endogenous Inhibitors in the Lamellae of Dairy Heifers With Oligofructose-Induced Laminitis

Frontiers in Veterinary Science, 2020
Bovine laminitis leads to huge economic losses and animal welfare problems in the dairy industry worldwide. Numerous studies suggested that several metalloproteinases (MPs) may play vital roles in the failure of epidermal attachment.
Jiafeng Ding, Jiafeng Ding, Mingxian Shi, Mingxian Shi, Long Wang, Long Wang, Dongdong Qi, Dongdong Qi, Ze Tao, Ze Tao, Muhammad A. Hayat, Muhammad A. Hayat, Tao Liu, Tao Liu, Jian-tao Zhang, Jian-tao Zhang, Hongbin Wang, Hongbin Wang   +17 more
doaj   +1 more source