Results 81 to 90 of about 11,544 (171)

Comparative assessment of changes ADAMTS-13/von Willebrand factor axis in singleton and bichorial biamniotic pregnancy

Акушерство, гинекология и репродукция
Aim: to compare changes in the ADAMTS-13 metalloproteinase/von Willebrand factor (vWF) axis in pregnant women with spontaneous or following in vitro fertilization (IVF) singleton and bichorial biamniotic pregnancies.Materials and Methods.
F. Е. Yagubova, V. O. Bitsadze, N. V. Samburova, J. Kh. Khizroeva, A. D. Makatsariya   +4 more
doaj   +1 more source

IMMUNOHISTOCHEMICAL ANALYSIS OF SFLT-1 AND ADAMTS-8 EXPRESSION IN DIABETIC RAT TESTIS TISSUE

International Journal of Health Services Research and Policy, 2019
he aim of this study was to determine the testicular inflammation and angiogenetic effect of diabetes with ADAMTS-8 and SFlt-1 proteins immunohistochemically.
Seval Kaya
doaj   +1 more source

Severe ADAMTS-13 deficiency without hemolysis as a cause of cryptogenic stroke: A single center case series

Journal of Stroke and Cerebrovascular Diseases
Introduction: Cerebral Infarction due to Severe ADAMTS-13 Deficiency (CISAD) remains an underrecognized cause of cryptogenic stroke. Despite the absence of classic hematologic features, CISAD confers a risk of recurrent ischemic events if not promptly ...
Johanna Seiden, MD, MPH, Juan Felipe Daza-Ovalle, MD, Zhengrui Xiao, MD, Olga Rubalsky, MD, Irina Murakhovskaya, MD, Ellen Friedman, MD, Kathryn Kirchoff-Torres, MD, Daniel Labovitz, MD, MS, Charles Esenwa, MD, MS   +8 more
doaj   +1 more source

Discovery of Isoindoline Amide Derivatives as Potent and Orally Bioavailable ADAMTS-4/5 Inhibitors for the Treatment of Osteoarthritis. [PDF]

ACS Pharmacol Transl Sci, 2022
Zhao P, Liu D, Song C, Li D, Zhang X, Horecny I, Zhang F, Yan Y, Zhuang L, Li J, Liu S, Mao Y, Feng J, Liu J, Tao W.   +14 more
europepmc   +1 more source

Proinflammatory and Anabolic Gene Expression Effects of Platelet-Rich Gel Supernatants on Equine Synovial Membrane Explants Challenged with Lipopolysaccharide

Veterinary Medicine International, 2017
Platelet-rich plasma (PRP) preparations are used in horses with osteoarthritis (OA). However, some controversies remain regarding the ideal concentration of platelets and leukocytes to produce an adequate anti-inflammatory and anabolic response in the ...
Jorge U. Carmona, Diana L. Ríos, Catalina López, María E. Álvarez, Jorge E. Pérez   +4 more
doaj   +1 more source

Transforming growth factor activating kinase 1 regulates extracellular matrix degrading enzymes and pain-related molecule expression following tumor necrosis factor-α stimulation of synovial cells: an in vitro study

BMC Musculoskeletal Disorders, 2017
Background Recent studies have suggested that the tumor necrosis factor-α (TNF-α) pathway is a potential target for the management of osteoarthritis (OA).
Kentaro Uchida, Shotaro Takano, Toshihide Matsumoto, Naoshige Nagura, Gen Inoue, Makoto Itakura, Masayuki Miyagi, Jun Aikawa, Dai Iwase, Atsushi Minatani, Hisako Fujimaki, Masashi Takaso   +11 more
doaj   +1 more source

Prophylactic use of recombinant ADAMTS-13 during pregnancy for congenital thrombotic thrombocytopenic purpura

Research and Practice in Thrombosis and Haemostasis
Background: Congenital thrombotic thrombocytopenic purpura (cTTP) related to ADAMTS-13 deficiency is associated with a maternal risk of death of 10% and a risk of fetal loss greater than 50% without treatment.
Éloïse Colliou, Agnès Ribes, Clotilde Gaible, Mathilde Marlas, David Ribes, Isabelle Labadens, Paul Guerby, Stanislas Faguer   +7 more
doaj   +1 more source

Regional Genetic Responses of Porcine Talar Articular Cartilage to Impact Injury

Foot & Ankle Orthopaedics, 2019
Category: Ankle Arthritis Introduction/Purpose: The ankle is at greatest risk for post-traumatic osteoarthritis (PTOA) in comparison to the hip or knee. Adaptive changes to the cartilaginous topography may be a marker for where cartilage damage poses the
Evan (Hank) Bryant, Kailey Mansour BS, C.Y. Charles Huang, Jonathan R. Kaplan MD, Amiethab A. Aiyer MD   +4 more
doaj   +1 more source

Poster 204: A Possible Cause of Articular Cartilage Degeneration in the Acute Phase after Anterior Cruciate Ligament Reconstruction

Orthopaedic Journal of Sports Medicine
Objectives: Intra-articular hemarthrosis contributes to the expression of various cytokines in articular injuries of knees. Exposure of articular cartilage to blood has been confirmed to induce irreversible cartilage damage.
Yudai Morita MD, Takuya Tajima MD, PhD, Nami Yamaguchi, Takuji Yokoe, Etsuo Chosa   +4 more
doaj   +1 more source

MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression. [PDF]

J Cell Mol Med, 2020
Li L, Ma W, Pan S, Li Y, Wang H, Wang B, Khalil RA.   +6 more
europepmc   +1 more source