Results 101 to 110 of about 12,875 (250)
Clinical Case Reports, Volume 13, Issue 4, April 2025.ABSTRACT Thrombotic microangiopathy (TMA) is a rare but severe complication in renal transplant recipients, often linked to tacrolimus. Early recognition and intervention, such as stopping the drug, are crucial to preventing graft loss. This case highlights the importance of prompt diagnosis and vigilance for subtle signs to ensure effective management.
Ahmad S. Matarneh +6 more
wiley +1 more source
A new name in thrombosis, ADAMTS13 [PDF]
Proceedings of the National Academy of Sciences, 2002 Thrombotic thrombocytopenic purpura (TTP) is a rapidly fatal illness, first described by Moschowitz in 1924 (1), that is characterized by anemia, a low platelet count (thrombocytopenia), and microvascular thrombosis. The anemia is caused by hemolysis and is associated with sharply pointed red cell fragments, termed schistocytes, that look as though ...
openaire +3 more sources
Caplacizumab treatment in elderly patients with iTTP: Experience from the Spanish TTP Registry
HemaSphere, Volume 9, Issue 4, April 2025.Abstract Immune thrombotic thrombocytopenic purpura (iTTP) typically affects middle‐aged individuals, although it sometimes appears in older patients. Caplacizumab is approved for the treatment of iTTP, but information on the safety and efficacy of this drug in elderly patients is not available.
Inés Gómez‐Seguí +20 more
wiley +1 more source
The allosteric activation of ADAMTS13 [PDF]
, 2018 ADAMTS13 regulates the multimeric size of Von Willebrand Factor (VWF) in plasma by specific, shear-dependent proteolysis. Despite circulating in a seemingly proteolytically competent form, and with a very long active plasma half-life, ADAMTS13 is specific for VWF, and is resistant to plasma inhibitors. This unprecedented specificity has been attributed
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Enzymatically Active ADAMTS13 Variants Are Not Inhibited by Anti-ADAMTS13 Autoantibodies [PDF]
Journal of Biological Chemistry, 2005 ADAMTS13 (a disintegrin and metalloprotease with thrombospondin motifs), a circulating multidomain zinc metalloprotease of the reprolysin subfamily, is critical for preventing von Willebrand factor-platelet interaction under high shear stress conditions.
David Ginsburg +4 more
openaire +3 more sources
International Journal of Hepatology, 2011 The liver plays a central role in hemostasis by synthesizing clotting factors, coagulation inhibitors, and fibrinolytic proteins. Liver cirrhosis (LC), therefore, impacts on both primary and secondary hemostatic mechanisms.
Masahito Uemura +5 more
doaj +1 more source
Therapeutic Plasma Exchange: Analysis of Practices and Compliance With International Guidelines
Journal of Clinical Apheresis, Volume 40, Issue 2, April 2025.ABSTRACT Therapeutic plasma exchange (TPE) is widely used in the treatment of autoimmune diseases and hematological emergencies. It is also applied in transplant patients for the desensitization of anti‐HLA (human leukocyte antigen) antibodies and the management of antibody‐mediated rejection.
Davi Mesquita Miranda +3 more
wiley +1 more source
Profound Thrombocytopenia and Dyspnea 11 Days After Cardiac Surgery
American Journal of Hematology, Volume 100, Issue 7, Page 1234-1239, July 2025.
Sebastian Vuong +3 more
wiley +1 more source
Clinical Case Reports, Volume 13, Issue 3, March 2025.ABSTRACT Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy (TMA) that is considered life‐threatening and caused by dysregulation of the complement system. Here, we report a previously healthy 8‐year‐old boy who presented with features of aHUS 1 week after viral symptoms during the COVID‐19 pandemic.
Parsa Lorestani +2 more
wiley +1 more source
Blood Advances, 2020 Acute ischemic stroke (IS) and transient ischemic attack (TIA) are associated with raised von Willebrand factor (VWF) and decreased ADAMTS13 activity (ADAMTS13Ac). Their impact on mortality and morbidity is unclear.
A. Taylor +4 more
semanticscholar +1 more source