Results 101 to 110 of about 20,502 (253)

Longitudinal assessments of plasma ADAMTS13 biomarkers predict recurrence of immune thrombotic thrombocytopenic purpura

Blood Advances, 2019
: Immune thrombotic thrombocytopenic purpura (iTTP) is primarily caused by immunoglobulin G (IgG)–type autoantibodies that bind and inhibit plasma ADAMTS13 activity and/or accelerate its clearance from circulation. Approximately 50% of patients with iTTP
Jingrui Sui, Wenjing Cao, Konstantine Halkidis, Mohammad S. Abdelgawwad, Nicole K. Kocher, Bryan Guillory, Lance A. Williams, Radhika Gangaraju, Marisa B. Marques, X. Long Zheng   +9 more
doaj   +1 more source

Systemic Lupus Erythematosus Presenting With Thrombotic Thrombocytopenic Purpura at Onset: A Case Report

Frontiers in Pediatrics, 2022
BackgroundThrombotic microangiopathy (TMA) is a syndrome associated with hemolytic anemia, thrombocytopenia, and various organ disorders. Thrombotic thrombocytopenic purpura (TTP) is a disease that develops when a disintegrin-like and metalloproteinase ...
Yoko Takagi, Yasuko Kobayashi, Ayako Hirakata, Mariko Takei, Satoshi Ogasawara, Chikage Yajima, Yuka Ikeuchi, Akira Matsumoto, Yoshiyuki Ogawa, Hiroshi Handa, Masanori Matsumoto, Hirokazu Arakawa, Takumi Takizawa   +12 more
doaj   +1 more source

ADAMTS13: A New Link Between Thrombosis and Inflammation [PDF]

, 2011
von Willebrand factor (VWF) levels are elevated and a disintegrin-like and metalloprotease with thrombospondin type I repeats–13 (ADAMTS13) activity is decreased in both acute and chronic inflammation.
Brill, Alexander, Chauhan, Anil K., Kisucka, Janka, Scheiflinger, Friedrich, Wagner, Denisa D., Walsh, Meghan T.   +5 more
core   +1 more source

ADAMTS13 activity to von Willebrand factor antigen ratio predicts acute kidney injury in patients with COVID‐19: Evidence of SARS‐CoV‐2 induced secondary thrombotic microangiopathy

International Journal of Laboratory Hematology, 2020
Severe COVID‐19 is often compounded by a prothrombotic state that is associated with poor outcomes. In this investigation, we aimed to evaluate ADAMTS13 activity, von Willebrand factor level (VWF:Ag), and the corresponding ADAMTS13 activity/VWF:Ag ratio,
B. Henry, S. Benoit, M. H. S. de Oliveira, G. Lippi, E. Favaloro, J. Benoit   +5 more
semanticscholar   +1 more source

Expression of ADAMTS13 and PCNA in the Placentas of Gestational Diabetic Mothers

, 2021
GDM is linked with overexpression of inflammatory cytokines and increased oxidative stress, leading to endothelial dysfunction and vascular disorder.
Süleyman Cemil Oğlak, M. Obut
semanticscholar   +1 more source

Reduced cleavage of von willebrand factor by ADAMTS13 is associated with microangiopathic acute kidney injury following trauma

Blood Coagulation and Fibrinolysis, 2021
Supplemental Digital Content is available in the text Acute kidney injury (AKI) is common after trauma, but contributory factors are incompletely understood.
William E Plautz, Shannon Haldeman, Mitchell R. Dyer, J. Sperry, Francis X. Guyette, P. Loughran, Jurgis Alvikas, Adnan Hassoune, Lara Hoteit, Nijmeh Alsaadi, B. Zuckerbraun, M. Rollins-Raval, J. Raval, R. Mota, M. Neal   +14 more
semanticscholar   +1 more source

A De Novo Splicing Mutation of SRP72 in Bone Marrow Failure Syndrome Type 1: Case Report and Review of the Literature

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
This study reports a rare case of bone marrow failure syndrome type 1 (BMFS1) caused by a novel de novo splicing mutation (c.1502+1G>A) in the SRP72 gene. The 6‐year‐old patient presented with aplastic anemia and pancytopenia. Genetic analysis identified the mutation, which was absent in both parents, confirming its de novo origin.
Wang Xiangwen, Zhang Duo, Hao Wenjing, Hou Hui   +3 more
wiley   +1 more source

Anti-ADAMTS13 autoantibody profiling in patients with immune-mediated thrombotic thrombocytopenic purpura.

Blood Advances, 2021
Anti-A Disintegrin and Metalloproteinase with a ThromboSpondin type 1 motif, member 13 (ADAMTS13) autoantibodies cause a severe ADAMTS13 deficiency in immune-mediated thrombotic thrombocytopenic purpura (iTTP). ADAMTS13 consists of a metalloprotease (M),
K. Kangro, E. Roose, B. Joly, G. Sinkovits, T. Falter, C. von Auer, H. Rossmann, M. Réti, J. Voorberg, Z. Prohászka, B. Lämmle, P. Coppo, A. Veyradier, S. D. De Meyer, Andres Männik, K. Vanhoorelbeke   +15 more
semanticscholar   +1 more source

Long‐Term Biobanked Dental Pulp Stem Cells Retain Angiogenic Potential for Vascularised Tissue Engineering—Laboratory Investigation

International Endodontic Journal, Volume 59, Issue 1, Page 105-118, January 2026.
ABSTRACT Aim This study aimed to evaluate whether human dental pulp stem cells (DPSCs), after long‐term biobanking (7–8 years), retain their pro‐angiogenic properties and can be used to engineer vascularised tissues, addressing their potential for clinical translation in regenerative dentistry.
Shuntaro Yamada, Katerina Holomkova, Åshild Johansen, Masoumeh Jahani Kadousaraei, Niyaz Al‐Sharabi, Francesco Torelli, Pierfrancesco Pagella, Ana Angelova Volponi, Hiroshi Egusa, Inge Fristad, Kamal Mustafa   +10 more
wiley   +1 more source

Pseudotumor Cerebri and Hemolytic Uremic Syndrome, A Rare Association

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Hemolytic uremic syndrome can present with central nervous system involvement. Idiopathic intracranial hypertension (IIH) is among the possible neurological manifestations of HUS, and clinicians should remain vigilant for extrarenal complications while treating patients with HUS.
Aasim Ali, Armaghana Abdullah, Mukesh Kumar Sharma, Anousha Tanveer, Muhammad Abdullah Mushtaq, Muhammad Mujtaba, Summaya Mushtaq   +6 more
wiley   +1 more source