Results 11 to 20 of about 20,502 (253)

ADAMTS13 activity decreases in the early phase of trauma associated with coagulopathy and systemic inflammation: a prospective observational study

Thrombosis Journal, 2021
Background We conducted a prospective observational study for investigating the changes in the 13th member of a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS13) and its association with the coagulofibrinolytic response in ...
Hironori Matsumoto, Jun Takeba, Kensuke Umakoshi, Satoshi Kikuchi, Muneaki Ohshita, Suguru Annen, Naoki Moriyama, Yuki Nakabayashi, Norio Sato, Mayuki Aibiki   +9 more
doaj   +2 more sources

Anti-ADAMTS13 Autoantibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura [PDF]

Antibodies
Autoantibodies to ADAMTS13 are at the center of pathology of the immune-mediated thrombotic thrombocytopenic purpura. These autoantibodies can be either inhibitory (enzymatic function) or non-inhibitory, resulting in protein depletion.
Michael R. Snyder, Robert W. Maitta
doaj   +2 more sources

Aberrant Expression of A Disintegrin and Metalloproteinase With Thrombospondin Motifs 13 (ADAMTS13) in Pancreatic Cancer Leads to Dichotomic Functions. [PDF]

MedComm (2020)
Allmang et al. demonstrated that ADAMTS13 is overexpressed in PDAC, associated with prolonged survival and reduced vascular density. Knockout of ADAMTS13 in PDAC cells led to a decrease in migration and invasion. In a xenograft model, loss of ADAMTS13 altered angiogenesis, vascular maturation, and reduced the expression of key angiogenic factors ...
Allmang S, Witzel HR, Hausen A, Marquard S, Eckert C, Marnet N, Hörner N, Mayer P, Heinrich S, Dang H, Roth W, Gaida MM.   +11 more
europepmc   +2 more sources

ADAMTS13 and Non-ADAMTS13 Biomarkers in Immune-Mediated Thrombotic Thrombocytopenic Purpura

Journal of Clinical Medicine, 2023
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare medical emergency for which a correct and early diagnosis is essential. As a severe deficiency in A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats, member 13 ...
Q. Bonnez, K. Sakai, K. Vanhoorelbeke
semanticscholar   +1 more source

Immune and Hereditary Thrombotic Thrombocytopenic Purpura: Can ADAMTS13 Deficiency Alone Explain the Different Clinical Phenotypes?

Journal of Clinical Medicine, 2023
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy caused by a hereditary or immune-mediated deficiency of the enzyme ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13).
S. Lancellotti, M. Sacco, M. Tardugno, A. Ferretti, R. De Cristofaro   +4 more
semanticscholar   +1 more source

Impaired exercise capacity in post–COVID-19 syndrome: the role of VWF-ADAMTS13 axis

Blood Advances, 2022
Post-COVID syndrome (PCS) or Long-COVID is an increasingly recognised complication of acute SARS-CoV-2 infection, characterised by persistent fatigue, reduced exercise tolerance chest pain, shortness of breath and cognitive slowing.
Nithya Prasannan, M. Heightman, T. Hillman, E. Wall, Robert Bell, Anna Kessler, L. Neave, A. Doyle, Akshitha Devaraj, Deepak Singh, Hakim-Moulay Dehbi, M. Scully   +11 more
semanticscholar   +1 more source

Mechanisms of ADAMTS13 regulation

Journal of Thrombosis and Haemostasis, 2022
Recombinant ADAMTS13 is currently undergoing clinical trials as a treatment for hereditary thrombotic thrombocytopenic purpura, a lethal microvascular condition resulting from ADAMTS13 deficiency.
V. DeYoung, Kanwal Singh, C. Kretz
semanticscholar   +1 more source

Peptidylarginine deiminase 4 and ADAMTS13 activity in Staphylococcus aureus bacteraemia

Philosophical Transactions of the Royal Society of London. Biological Sciences, 2023
Staphylococcus aureus infection is associated with increased levels of neutrophil extracellular traps (NETs) and von Willebrand factor (VWF), and with reduced activity of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs ...
C. Martens, M. Peetermans, T. Vanassche, P. Verhamme, M. Jacquemin, K. Martinod   +5 more
semanticscholar   +1 more source

Recombinant ADAMTS13 for Hereditary Thrombotic Thrombocytopenic Purpura.

New England Journal of Medicine, 2022
A 27-year-old patient with a history of severe obstetrical complications and arterial thrombosis received a diagnosis of hereditary thrombotic thrombocytopenic purpura (TTP) due to severe ADAMTS13 deficiency when she presented with an acute episode in ...
L. Asmis, A. Serra, A. Krafft, A. Licht, E. Leisinger, J. Henschkowski-Serra, M. Ganter, S. Hauptmann, M. Tinguely, J. K. Kremer Hovinga   +9 more
semanticscholar   +1 more source

The Intriguing Connections between von Willebrand Factor, ADAMTS13 and Cancer

Healthcare, 2022
von Willebrand factor (VWF) is a complex and large protein that is cleaved by ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13), and together they serve important roles in normal hemostasis.
Chanukya K Colonne, E. Favaloro, Leonardo Pasalic   +2 more
semanticscholar   +1 more source