Results 51 to 60 of about 12,875 (250)

The ADAMTS13‐von Willebrand factor axis in COVID‐19 patients

Journal of Thrombosis and Haemostasis, 2020
Severe coronavirus disease 2019 (COVID‐19) is characterized by an increased risk of thromboembolic events, with evidence of microthrombosis in the lungs of deceased patients.
I. Mancini, L. Baronciani, A. Artoni, P. Colpani, Marina Biganzoli, G. Cozzi, C. Novembrino, Massimo Boscolo Anzoletti, Valentina de Zan, M. T. Pagliari, R. Gualtierotti, S. Aliberti, M. Panigada, G. Grasselli, F. Blasi, F. Peyvandi   +15 more
semanticscholar   +1 more source

Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions

Frontiers in Medicine, 2017
Platelet recruitment to sites of vascular injury is mediated by von Willebrand factor (VWF). The shear-induced unraveling of ultra-large VWF multimers causes the formation of a “stringlike” conformation, which rapidly recruits platelets from the ...
Kathleen S. Garland, Kathleen S. Garland, Stéphanie E. Reitsma, Stéphanie E. Reitsma, Toshiaki Shirai, Jevgenia Zilberman-Rudenko, Erik I. Tucker, Erik I. Tucker, David Gailani, András Gruber, András Gruber, Owen J. T. McCarty, Cristina Puy   +12 more
doaj   +1 more source

ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis

Journal of Neuroinflammation, 2020
Background ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13) plays a vital role in preventing microvascular thrombosis and inflammation.
Kaili Lu, Lan Liu, Xiaofeng Xu, Fei Zhao, Jiangshan Deng, Xin Tang, Xiuzhe Wang, Bing-Qiao Zhao, Xiaojie Zhang, Yuwu Zhao   +9 more
doaj   +1 more source

Von Willebrand factor collagen-binding capacity predicts in-hospital mortality in COVID-19 patients: insight from VWF/ADAMTS13 ratio imbalance

Angiogenesis, 2021
Microthrombosis is a hallmark of COVID-19. We previously described von willebrand factor (VWF) and their high molecular weight multimers (HMWMs) as potential trigger of microthrombosis. Investigate VWF activity with collagen-binding assay and ADAMTS13 in
A. Philippe, N. Gendron, O. Bory, Agathe Beauvais, T. Mirault, B. Planquette, O. Sanchez, J. Diehl, R. Chocron, D. Smadja   +9 more
semanticscholar   +1 more source

Laboratory testing for ADAMTS13: Utility for TTP diagnosis/exclusion and beyond

American journal of hematology/oncology, 2021
The metalloproteinase ADAMTS13 (a disintegrin with a thrombospondin type 1 motif, member 13), also known as VWF (von Willebrand factor) protease, may be assessed in a vast array of clinical conditions.
E. Favaloro, Leonardo Pasalic, B. Henry, G. Lippi   +3 more
semanticscholar   +1 more source

Robust thrombolytic and anti-inflammatory action of a constitutively active ADAMTS13 variant in murine stroke models

Blood, 2021
Advances in our understanding of ADAMTS13 structure, and the conformation changes required for full activity, have rejuvenated the possibility of its use as a thrombolytic therapy. We have tested a novel Ala1144Val ADAMTS13 variant (constitutively active
K. South, O. Saleh, Eloise Lemarchand, Graham Coutts, Craig J. Smith, I. Schiessl, S. Allan   +6 more
semanticscholar   +1 more source

Evidence for a role of anti-ADAMTS13 autoantibodies despite normal ADAMTS13 activity in recurrent thrombotic thrombocytopenic purpura

Haematologica, 2012
Background Severe ADAMTS13 deficiency is a critical component of the pathogenesis of idiopathic thrombotic thrombocytopenic purpura but is found only in about 60% of patients clinically diagnosed with this disease.Design and Methods Over a period of 8 ...
Rahel Froehlich-Zahnd, James N. George, Sara K. Vesely, Deirdra R. Terrell, Khatira Aboulfatova, Jing-Fei Dong, Brenda M. Luken, Jan Voorberg, Ulrich Budde, Irmela Sulzer, Bernhard Lämmle, Johanna A. Kremer Hovinga   +11 more
doaj   +1 more source

ADAMTS13 in pediatric sepsis: a prognostic biomarker with potential therapeutic implications

Egyptian Pediatric Association Gazette, 2023
Background Growing evidence implicates a pro-thrombotic state, caused by ADAMTS13 deficiency, in sepsis-associated organ dysfunction, but pediatric data is limited.
Muhammad Said El-Mekkawy, Sara Mahmoud El-Deeb, Maha Fawzy El-Hanafy   +2 more
doaj   +1 more source

Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13

Frontiers in Immunology, 2020
Both neutrophil extracellular traps (NETs) and von Willebrand factor (VWF) are essential for thrombosis and inflammation. During these processes, a complex series of events, including endothelial activation, NET formation, VWF secretion, and blood cell ...
Junxian Yang, Zhiwei Wu, Q. Long, Jiaqi Huang, Tiantian Hong, Wang Liu, Jiangguo Lin   +6 more
semanticscholar   +1 more source

Von Willebrand factor and ADAMTS13 activity as clinical severity markers in patients with COVID-19

Journal of Thrombosis and Thrombolysis, 2021
The coronavirus disease 2019 (COVID-19) increases thrombotic risk. The mechanisms that lead to this prothrombotic state are not well established. The main aim was to evaluate the von Willebrand factor (VWF) antigen and plasma ADAMTS13 activity as ...
A. Marco, P. Marco
semanticscholar   +1 more source