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The Adipocyte and Adaptive Immunity [PDF]
Frontiers in Immunology, 2020 Not only do Adipocytes have energy storage and endocrine functions, but they also play an immunological role. Adipocytes are involved in adaptive immunity to mediate the pathological processes of a variety of chronic inflammatory diseases and autoimmune ...
Jianfeng Song +4 more
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Adaptive immunity in the neuroinflammation of Alzheimer’s disease [PDF]
Chinese Medical Journal. Alzheimer’s disease (AD) is the most common cause of dementia and is a growing public health challenge. Neuroinflammation has been proposed as a prominent pathological feature of AD and has traditionally been attributed to the innate immune system ...
Hanchen Liu +4 more
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Role of platelets and megakaryocytes in adaptive immunity
Platelets, 2021 The immune system is comprised of two principal interconnected components called innate and adaptive immunity. While the innate immune system mounts a nonspecific response that provides protection against the spread of foreign pathogens, the adaptive ...
Genevieve Marcoux +3 more
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eLife, 2023 Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote tumor growth by inhibiting anticancer immunity.
Oksana Tsyklauri +13 more
doaj +1 more source
Frontiers in Immunology, 2022 Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate ...
Darina Paprckova +22 more
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Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
Nature Immunology, 2022 Despite the success of the BNT162b2 mRNA vaccine, the immunological mechanisms that underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive responses to BNT162b2 in mice, and show that immunization stimulated potent antibody
Chunfeng Li +23 more
semanticscholar +1 more source
Pinpointing the tumor-specific T cells via TCR clusters
eLife, 2022 Adoptive cell transfer (ACT) is a promising approach to cancer immunotherapy, but its efficiency fundamentally depends on the extent of tumor-specific T cell enrichment within the graft. This can be estimated via activation with identifiable neoantigens,
Mikhail M Goncharov +12 more
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Measuring Intratumoral Heterogeneity of Immune Repertoires
Frontiers in Oncology, 2020 There is considerable clinical and fundamental value in measuring the clonal heterogeneity of T and B cell expansions in tumors and tumor-associated lymphoid structures—along with the associated heterogeneity of the tumor neoantigen landscape—but such ...
Diana Vladimirovna Yuzhakova +30 more
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Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
Nature Communications, 2022 Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive this ...
Martha Triantafilou +11 more
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Frontiers in Oncology, 2020 Substantial effort is being invested in the search for peripheral or intratumoral T cell receptor (TCR) repertoire features that could predict the response to immunotherapy.
Ekaterina A. Zhigalova +19 more
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