Results 1 to 10 of about 5,085,110 (360)

Adaptive immunity in the neuroinflammation of Alzheimer’s disease [PDF]

Chinese Medical Journal
. Alzheimer’s disease (AD) is the most common cause of dementia and is a growing public health challenge. Neuroinflammation has been proposed as a prominent pathological feature of AD and has traditionally been attributed to the innate immune system ...
Hanchen Liu, Yun Chen, Jing Zhang, Xiaochun Chen, Ting Gao   +4 more
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Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2

eLife, 2023
Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote tumor growth by inhibiting anticancer immunity.
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek   +13 more
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Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

Frontiers in Immunology, 2022
Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate ...
Darina Paprckova, Veronika Niederlova, Veronika Niederlova, Alena Moudra, Ales Drobek, Michaela Pribikova, Michaela Pribikova, Sarka Janusova, Kilian Schober, Kilian Schober, Ales Neuwirth, Juraj Michalik, Martina Huranova, Veronika Horkova, Michaela Cesnekova, Michaela Cesnekova, Michaela Simova, Jan Prochazka, Jana Balounova, Dirk H. Busch, Radislav Sedlacek, Martin Schwarzer, Ondrej Stepanek   +22 more
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Measuring Intratumoral Heterogeneity of Immune Repertoires

Frontiers in Oncology, 2020
There is considerable clinical and fundamental value in measuring the clonal heterogeneity of T and B cell expansions in tumors and tumor-associated lymphoid structures—along with the associated heterogeneity of the tumor neoantigen landscape—but such ...
Diana Vladimirovna Yuzhakova, Lilia N. Volchkova, Mikhail Valerievich Pogorelyy, Mikhail Valerievich Pogorelyy, Ekaterina O. Serebrovskaya, Ekaterina O. Serebrovskaya, Irina A. Shagina, Irina A. Shagina, Ekaterina A. Bryushkova, Ekaterina A. Bryushkova, Tatiana O. Nakonechnaya, Tatiana O. Nakonechnaya, Tatiana O. Nakonechnaya, Anna V. Izosimova, Daria S. Zavyalova, Maria M. Karabut, Mark Izraelson, Mark Izraelson, Mark Izraelson, Igor V. Samoylenko, Vladimir E. Zagainov, Vladimir E. Zagainov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Elena V. Zagaynova, George Vladimirovich Sharonov, George Vladimirovich Sharonov, George Vladimirovich Sharonov   +30 more
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Pinpointing the tumor-specific T cells via TCR clusters

eLife, 2022
Adoptive cell transfer (ACT) is a promising approach to cancer immunotherapy, but its efficiency fundamentally depends on the extent of tumor-specific T cell enrichment within the graft. This can be estimated via activation with identifiable neoantigens,
Mikhail M Goncharov, Ekaterina A Bryushkova, Nikita I Sharaev, Valeria D Skatova, Anastasiya M Baryshnikova, George V Sharonov, Vadim Karnaukhov, Maria T Vakhitova, Igor V Samoylenko, Lev V Demidov, Sergey Lukyanov, Dmitriy M Chudakov, Ekaterina O Serebrovskaya   +12 more
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Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication

Nature Communications, 2022
Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive this ...
Martha Triantafilou, Joshi Ramanjulu, Lee M. Booty, Gisela Jimenez-Duran, Hakan Keles, Ken Saunders, Neysa Nevins, Emma Koppe, Louise K. Modis, G. Scott Pesiridis, John Bertin, Kathy Triantafilou   +11 more
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RNA-Seq-Based TCR Profiling Reveals Persistently Increased Intratumoral Clonality in Responders to Anti-PD-1 Therapy

Frontiers in Oncology, 2020
Substantial effort is being invested in the search for peripheral or intratumoral T cell receptor (TCR) repertoire features that could predict the response to immunotherapy.
Ekaterina A. Zhigalova, Anna I. Izosimova, Diana V. Yuzhakova, Lilia N. Volchkova, Irina A. Shagina, Irina A. Shagina, Maria A. Turchaninova, Maria A. Turchaninova, Maria A. Turchaninova, Ekaterina O. Serebrovskaya, Ekaterina O. Serebrovskaya, Ekaterina O. Serebrovskaya, Elena V. Zagaynova, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, George V. Sharonov, George V. Sharonov, George V. Sharonov   +19 more
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The use of non-functional clonotypes as a natural calibrator for quantitative bias correction in adaptive immune receptor repertoire profiling

eLife, 2023
High-throughput sequencing of adaptive immune receptor repertoires is a valuable tool for receiving insights in adaptive immunity studies. Several powerful TCR/BCR repertoire reconstruction and analysis methods have been developed in the past decade ...
Anastasia O Smirnova, Anna M Miroshnichenkova, Yulia V Olshanskaya, Michael A Maschan, Yuri B Lebedev, Dmitriy M Chudakov, Ilgar Z Mamedov, Alexander Komkov   +7 more
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Novel bimodal TRBD1-TRBD2 rearrangements with dual or absent D-region contribute to TRB V-(D)-J combinatorial diversity

Frontiers in Immunology, 2023
T-cell receptor (TR) diversity of the variable domains is generated by recombination of both the alpha (TRA) and beta (TRB) chains. The textbook process of TRB chain production starts with TRBD and TRBJ gene rearrangement, followed by the rearrangement ...
Anastasia O. Smirnova, Anastasia O. Smirnova, Anna M. Miroshnichenkova, Laima D. Belyaeva, Ilya V. Kelmanson, Yuri B. Lebedev, Yuri B. Lebedev, Ilgar Z. Mamedov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Alexander Y. Komkov, Alexander Y. Komkov, Alexander Y. Komkov   +14 more
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Pharmacological validation of targets regulating CD14 during macrophage differentiation

EBioMedicine, 2020
The signalling receptor for LPS, CD14, is a key marker of, and facilitator for, pro-inflammatory macrophage function. Pro-inflammatory macrophage differentiation remains a process facilitating a broad array of disease pathologies, and has recently ...
Gisela Jimenez-Duran, Rosario Luque-Martin, Meghana Patel, Emma Koppe, Sharon Bernard, Catriona Sharp, Natalie Buchan, Ceara Rea, Menno P.J. de Winther, Nil Turan, Davina Angell, Christine A. Wells, Rick Cousins, Palwinder K. Mander, Seth L. Masters   +14 more
doaj   +1 more source