Results 11 to 20 of about 274,536 (135)

Exploring the pre-immune landscape of antigen-specific T cells

Genome Medicine, 2018
Background Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells.
Mikhail V. Pogorelyy, Alla D. Fedorova, James E. McLaren, Kristin Ladell, Dmitri V. Bagaev, Alexey V. Eliseev, Artem I. Mikelov, Anna E. Koneva, Ivan V. Zvyagin, David A. Price, Dmitry M. Chudakov, Mikhail Shugay   +11 more
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TCR repertoire profiling revealed antigen-driven CD8+ T cell clonal groups shared in synovial fluid of patients with spondyloarthritis

Frontiers in Immunology, 2022
Spondyloarthritis (SpA) comprises a number of inflammatory rheumatic diseases with overlapping clinical manifestations. Strong association with several HLA-I alleles and T cell infiltration into an inflamed joint suggest involvement of T cells in SpA ...
Ekaterina A. Komech, Ekaterina A. Komech, Anastasia D. Koltakova, Anna A. Barinova, Anna A. Barinova, Anastasia A. Minervina, Maria A. Salnikova, Evgeniya I. Shmidt, Tatiana V. Korotaeva, Elena Y. Loginova, Shandor F. Erdes, Ekaterina A. Bogdanova, Ekaterina A. Bogdanova, Mikhail Shugay, Mikhail Shugay, Sergey Lukyanov, Sergey Lukyanov, Yury B. Lebedev, Yury B. Lebedev, Ivan V. Zvyagin, Ivan V. Zvyagin   +20 more
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Comparative Analysis of B-Cell Receptor Repertoires Induced by Live Yellow Fever Vaccine in Young and Middle-Age Donors

Frontiers in Immunology, 2018
Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination.
Alexey N. Davydov, Anna S. Obraztsova, Anna S. Obraztsova, Mikhail Y. Lebedin, Maria A. Turchaninova, Maria A. Turchaninova, Maria A. Turchaninova, Dmitriy B. Staroverov, Dmitriy B. Staroverov, Ekaterina M. Merzlyak, Ekaterina M. Merzlyak, George V. Sharonov, George V. Sharonov, Olga Kladova, Mikhail Shugay, Mikhail Shugay, Mikhail Shugay, Mikhail Shugay, Olga V. Britanova, Olga V. Britanova, Olga V. Britanova, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov   +25 more
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Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes

Journal for ImmunoTherapy of Cancer, 2019
Background The role of tumor-infiltrating B-cells (TIBs) and intratumorally-produced antibodies in cancer-immunity interactions essentially remains terra incognita.
O. I. Isaeva, G. V. Sharonov, E. O. Serebrovskaya, M. A. Turchaninova, A. R. Zaretsky, M. Shugay, D. M. Chudakov   +6 more
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Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs

eLife, 2020
The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4+ T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptors (TCRs).
Sofya A Kasatskaya, Kristin Ladell, Evgeniy S Egorov, Kelly L Miners, Alexey N Davydov, Maria Metsger, Dmitry B Staroverov, Elena K Matveyshina, Irina A Shagina, Ilgar Z Mamedov, Mark Izraelson, Pavel V Shelyakin, Olga V Britanova, David A Price, Dmitriy M Chudakov   +14 more
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Inactivated tick-borne encephalitis vaccine elicits several overlapping waves of T cell response

Frontiers in Immunology, 2022
The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century.
Anastasiia L. Sycheva, Ekaterina A. Komech, Ekaterina A. Komech, Mikhail V. Pogorelyy, Anastasia A. Minervina, Shamil Z. Urazbakhtin, Maria A. Salnikova, Maria A. Salnikova, Mikhail F. Vorovitch, Mikhail F. Vorovitch, Eugene P. Kopantzev, Ivan V. Zvyagin, Ivan V. Zvyagin, Alexander Y. Komkov, Alexander Y. Komkov, Ilgar Z. Mamedov, Yuri B. Lebedev, Yuri B. Lebedev   +17 more
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Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood

Frontiers in Immunology, 2021
T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In this work, we analyzed this subset for NKG2C expression. In both CD56+ and CD56− subsets most of the NKG2C+ T cells had a phenotype of
Elena I. Kovalenko, Ivan V. Zvyagin, Maria A. Streltsova, Artem I. Mikelov, Artem I. Mikelov, Sofya A. Erokhina, William G. Telford, Alexander M. Sapozhnikov, Yury B. Lebedev   +8 more
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CXCL12 Mediates Aberrant Costimulation of B Lymphocytes in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Immunodeficiency

Frontiers in Immunology, 2017
The Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is an immunodeficiency caused by mutations in chemokine receptor CXCR4. WHIM patient adaptive immunity defects remain largely unexplained.
Giuliana Roselli, Elisa Martini, Vassilios Lougaris, Raffaele Badolato, Antonella Viola, Antonella Viola, Marinos Kallikourdis, Marinos Kallikourdis   +7 more
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Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

Cell Reports, 2020
Summary: Overtly self-reactive T cells are removed during thymic selection. However, it has been recently established that T cell self-reactivity promotes protective immune responses.
Veronika Horkova, Ales Drobek, Daniel Mueller, Celine Gubser, Veronika Niederlova, Lena Wyss, Carolyn G. King, Dietmar Zehn, Ondrej Stepanek   +8 more
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Method for identification of condition-associated public antigen receptor sequences

eLife, 2018
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease ...
Mikhail V Pogorelyy, Anastasia A Minervina, Dmitriy M Chudakov, Ilgar Z Mamedov, Yuri B Lebedev, Thierry Mora, Aleksandra M Walczak   +6 more
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