Results 11 to 20 of about 4,855,871 (373)
The Adipocyte and Adaptive Immunity
Frontiers in Immunology, 2020 Not only do Adipocytes have energy storage and endocrine functions, but they also play an immunological role. Adipocytes are involved in adaptive immunity to mediate the pathological processes of a variety of chronic inflammatory diseases and autoimmune ...
Jianfeng Song +4 more
doaj +2 more sources
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Nature, 1997 Ruslan Medzhitov +2 more
openalex +2 more sources
Role of platelets and megakaryocytes in adaptive immunity
Platelets, 2021 The immune system is comprised of two principal interconnected components called innate and adaptive immunity. While the innate immune system mounts a nonspecific response that provides protection against the spread of foreign pathogens, the adaptive ...
Genevieve Marcoux +3 more
doaj +2 more sources
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
Nature Immunology, 2022 Despite the success of the BNT162b2 mRNA vaccine, the immunological mechanisms that underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive responses to BNT162b2 in mice, and show that immunization stimulated potent antibody
Chunfeng Li +23 more
semanticscholar +1 more source
Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity
Circulation Research, 2022 Classically, platelets have been described as the cellular blood component that mediates hemostasis and thrombosis. This important platelet function has received significant research attention for >150 years.
Milka Koupenova, A. Livada, C. Morrell
semanticscholar +1 more source
Periphery and brain, innate and adaptive immunity in Parkinson’s disease
Acta Neuropathologica, 2021 Parkinson’s disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a central role in the death and dysfunction of neurons, both, in central, as well as in the peripheral nervous system.
A. Harms +2 more
semanticscholar +1 more source
NLRP3 Inflammasome: Checkpoint Connecting Innate and Adaptive Immunity in Autoimmune Diseases
Frontiers in Immunology, 2021 Autoimmune diseases are a broad spectrum of human diseases that are characterized by the breakdown of immune tolerance and the production of autoantibodies.
Yiwen Zhang +3 more
semanticscholar +1 more source
Understanding Early-Life Adaptive Immunity to Guide Interventions for Pediatric Health
Frontiers in Immunology, 2021 Infants are capable of mounting adaptive immune responses, but their ability to develop long-lasting immunity is limited. Understanding the particularities of the neonatal adaptive immune system is therefore critical to guide the design of immune-based ...
E. C. Semmes +5 more
semanticscholar +1 more source
Frontiers in Immunology, 2022 Spondyloarthritis (SpA) comprises a number of inflammatory rheumatic diseases with overlapping clinical manifestations. Strong association with several HLA-I alleles and T cell infiltration into an inflamed joint suggest involvement of T cells in SpA ...
Ekaterina A. Komech +20 more
doaj +1 more source
Exploring the pre-immune landscape of antigen-specific T cells
Genome Medicine, 2018 Background Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells.
Mikhail V. Pogorelyy +11 more
doaj +1 more source