Results 11 to 20 of about 5,026,401 (367)

Adaptive Immunity in Hypertension [PDF]

Current Hypertension Reports, 2019
In recent years, a vast body of evidence has accumulated indicating the role of the immune system in the regulation of blood pressure and modulation of hypertensive pathology.
T. Mikołajczyk, T. Guzik
semanticscholar   +3 more sources

Adaptive immunity in the liver [PDF]

Cellular & Molecular Immunology, 2016
The anatomical architecture of the human liver and the diversity of its immune components endow the liver with its physiological function of immune competence. Adaptive immunity is a major arm of the immune system that is organized in a highly specialized and systematic manner, thus providing long-lasting protection with immunological memory.
Shuai, Zongwen, Leung, Miranda WY, He, Xiaosong, Zhang, Weici, Yang, Guoxiang, Leung, Patrick SC, Eric Gershwin, M   +6 more
openaire   +2 more sources

Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity

Circulation Research, 2022
Classically, platelets have been described as the cellular blood component that mediates hemostasis and thrombosis. This important platelet function has received significant research attention for >150 years.
Milka Koupenova, Alison C. Livada, C. Morrell   +2 more
semanticscholar   +1 more source

The use of non-functional clonotypes as a natural calibrator for quantitative bias correction in adaptive immune receptor repertoire profiling

eLife, 2023
High-throughput sequencing of adaptive immune receptor repertoires is a valuable tool for receiving insights in adaptive immunity studies. Several powerful TCR/BCR repertoire reconstruction and analysis methods have been developed in the past decade ...
Anastasia O Smirnova, Anna M Miroshnichenkova, Yulia V Olshanskaya, Michael A Maschan, Yuri B Lebedev, Dmitriy M Chudakov, Ilgar Z Mamedov, Alexander Komkov   +7 more
doaj   +1 more source

Novel bimodal TRBD1-TRBD2 rearrangements with dual or absent D-region contribute to TRB V-(D)-J combinatorial diversity

Frontiers in Immunology, 2023
T-cell receptor (TR) diversity of the variable domains is generated by recombination of both the alpha (TRA) and beta (TRB) chains. The textbook process of TRB chain production starts with TRBD and TRBJ gene rearrangement, followed by the rearrangement ...
Anastasia O. Smirnova, Anastasia O. Smirnova, Anna M. Miroshnichenkova, Laima D. Belyaeva, Ilya V. Kelmanson, Yuri B. Lebedev, Yuri B. Lebedev, Ilgar Z. Mamedov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Alexander Y. Komkov, Alexander Y. Komkov, Alexander Y. Komkov   +14 more
doaj   +1 more source

Adaptive Immunity to Fungi [PDF]

Annual Review of Immunology, 2012
Only a handful of the more than 100,000 fungal species on our planet cause disease in humans, yet the number of life-threatening fungal infections in patients has recently skyrocketed as a result of advances in medical care that often suppress immunity intensely.
Marcel, Wüthrich, George S, Deepe, Bruce, Klein   +2 more
openaire   +2 more sources

Pharmacological validation of targets regulating CD14 during macrophage differentiation

EBioMedicine, 2020
The signalling receptor for LPS, CD14, is a key marker of, and facilitator for, pro-inflammatory macrophage function. Pro-inflammatory macrophage differentiation remains a process facilitating a broad array of disease pathologies, and has recently ...
Gisela Jimenez-Duran, Rosario Luque-Martin, Meghana Patel, Emma Koppe, Sharon Bernard, Catriona Sharp, Natalie Buchan, Ceara Rea, Menno P.J. de Winther, Nil Turan, Davina Angell, Christine A. Wells, Rick Cousins, Palwinder K. Mander, Seth L. Masters   +14 more
doaj   +1 more source

Periphery and brain, innate and adaptive immunity in Parkinson’s disease

Acta Neuropathologica, 2021
Parkinson’s disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a central role in the death and dysfunction of neurons, both, in central, as well as in the peripheral nervous system.
A. Harms, Sara A. Ferreira, M. Romero-Ramos   +2 more
semanticscholar   +1 more source

Adaptive Immunity to Fungi [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
Life-threatening fungal infections have risen sharply in recent years, owing to the advances and intensity of medical care that may blunt immunity in patients. This emerging crisis has created the growing need to clarify immune defense mechanisms against fungi with the ultimate goal of therapeutic intervention.
Akash, Verma, Marcel, Wüthrich, George, Deepe, Bruce, Klein   +3 more
openaire   +2 more sources

TCR repertoire profiling revealed antigen-driven CD8+ T cell clonal groups shared in synovial fluid of patients with spondyloarthritis

Frontiers in Immunology, 2022
Spondyloarthritis (SpA) comprises a number of inflammatory rheumatic diseases with overlapping clinical manifestations. Strong association with several HLA-I alleles and T cell infiltration into an inflamed joint suggest involvement of T cells in SpA ...
Ekaterina A. Komech, Ekaterina A. Komech, Anastasia D. Koltakova, Anna A. Barinova, Anna A. Barinova, Anastasia A. Minervina, Maria A. Salnikova, Evgeniya I. Shmidt, Tatiana V. Korotaeva, Elena Y. Loginova, Shandor F. Erdes, Ekaterina A. Bogdanova, Ekaterina A. Bogdanova, Mikhail Shugay, Mikhail Shugay, Sergey Lukyanov, Sergey Lukyanov, Yury B. Lebedev, Yury B. Lebedev, Ivan V. Zvyagin, Ivan V. Zvyagin   +20 more
doaj   +1 more source