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Adaptive immunity, chronic inflammation and the clock
Seminars in Immunopathology, 2022 The adaptive arm of the immune system facilitates recognition of specific foreign pathogens and, via the action of T and B lymphocytes, induces a fine-tuned response to target the pathogen and develop immunological memory.
K. Gray, J. Gibbs
semanticscholar +1 more source
Adaptive immunity or evolutionary adaptation? Transgenerational immune systems at the crossroads
Biology & Philosophy, 2022 AbstractIn recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive immune system. Particularly the discovery of CRISPR-Cas9-based systems has triggered a discussion about how to classify adaptive ...
openaire +3 more sources
Exploring the pre-immune landscape of antigen-specific T cells
Genome Medicine, 2018 Background Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells.
Mikhail V. Pogorelyy +11 more
doaj +1 more source
'Towards a Conceptual Framework for Innate Immunity' [PDF]
, 2005 Innate immunity now occupies a central role in immunology. However, artificial immune system models have largely been inspired by adaptive not innate immunity.
Aickelin, Uwe, Twycross, Jamie
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NLRP3 Inflammasome: Checkpoint Connecting Innate and Adaptive Immunity in Autoimmune Diseases
Frontiers in Immunology, 2021 Autoimmune diseases are a broad spectrum of human diseases that are characterized by the breakdown of immune tolerance and the production of autoantibodies.
Yiwen Zhang +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2018 Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination.
Alexey N. Davydov +25 more
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Intestinal macromolecular transport supporting adaptive immunity [PDF]
, 2019 The gastrointestinal tract performs opposing functions of nutrient absorption, barrier maintenance, and the delivery of luminal substances for the appropriate induction of tolerogenic or protective adaptive immunity.
Kulkarni, Devesha H, Newberry, Rodney D
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Understanding Early-Life Adaptive Immunity to Guide Interventions for Pediatric Health
Frontiers in Immunology, 2021 Infants are capable of mounting adaptive immune responses, but their ability to develop long-lasting immunity is limited. Understanding the particularities of the neonatal adaptive immune system is therefore critical to guide the design of immune-based ...
E. C. Semmes +5 more
semanticscholar +1 more source
Adaptive Immunity and Inflammation [PDF]
International Journal of Inflammation, 2015 Inflammation is part of a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. Local signals at the sites of inflammation mediate rapid cells mobilization and recruitment and dictate differentiation programs whereby these cells drive clearance of “inflammatory inducers” and promote ...
Brancaleone Vincenzo +3 more
doaj +3 more sources
Livestock abundance predicts vampire bat demography, immune profiles, and bacterial infection risk [PDF]
, 2018 Human activities create novel food resources that can alter wildlife–pathogen interactions. If resources amplify or dampen, pathogen transmission probably depends on both host ecology and pathogen biology, but studies that measure responses to ...
Altizer, Sonia +13 more
core +3 more sources