Results 21 to 30 of about 4,855,871 (373)

Comparative Analysis of B-Cell Receptor Repertoires Induced by Live Yellow Fever Vaccine in Young and Middle-Age Donors

Frontiers in Immunology, 2018
Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination.
Alexey N. Davydov, Anna S. Obraztsova, Anna S. Obraztsova, Mikhail Y. Lebedin, Maria A. Turchaninova, Maria A. Turchaninova, Maria A. Turchaninova, Dmitriy B. Staroverov, Dmitriy B. Staroverov, Ekaterina M. Merzlyak, Ekaterina M. Merzlyak, George V. Sharonov, George V. Sharonov, Olga Kladova, Mikhail Shugay, Mikhail Shugay, Mikhail Shugay, Mikhail Shugay, Olga V. Britanova, Olga V. Britanova, Olga V. Britanova, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov   +25 more
doaj   +1 more source

Intestinal macromolecular transport supporting adaptive immunity [PDF]

, 2019
The gastrointestinal tract performs opposing functions of nutrient absorption, barrier maintenance, and the delivery of luminal substances for the appropriate induction of tolerogenic or protective adaptive immunity.
Kulkarni, Devesha H, Newberry, Rodney D
core   +2 more sources

Adaptive immunity in cancer immunology and therapeutics. [PDF]

, 2014
Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution,
Lockley, M, Spurrell, EL
core   +2 more sources

Inactivated tick-borne encephalitis vaccine elicits several overlapping waves of T cell response

Frontiers in Immunology, 2022
The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century.
Anastasiia L. Sycheva, Ekaterina A. Komech, Ekaterina A. Komech, Mikhail V. Pogorelyy, Anastasia A. Minervina, Shamil Z. Urazbakhtin, Maria A. Salnikova, Maria A. Salnikova, Mikhail F. Vorovitch, Mikhail F. Vorovitch, Eugene P. Kopantzev, Ivan V. Zvyagin, Ivan V. Zvyagin, Alexander Y. Komkov, Alexander Y. Komkov, Ilgar Z. Mamedov, Yuri B. Lebedev, Yuri B. Lebedev   +17 more
doaj   +1 more source

CD98hc facilitates B cell proliferation and adaptive humoral immunity. [PDF]

, 2009
The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-specific deletion of the heavy chain of CD98 (CD98hc) resulted in lower antibody responses due to total ...
A Mondino, AP Warren, AW Freidman, C Brakebusch, CA Fenczik, CA Fenczik, CC Feral, CC Feral, Cecille D Browne, CG Lo, CG Proud, Chloé C Féral, CL Abram, D Torrents, DC Otero, DE White, DM Rose, E Arana, F Esteban, FD Batista, FM Burnet, GW Prager, H Tsumura, J Bertran, J Fernandez-Herrera, J Hasbold, JG Cyster, JH Kehrl, JL Walker, Joseph Cantor, K Hara, K Roovers, KB Lin, KL Wolniak, L Kass, L Van Parijs, LA Diaz Jr., MA Schwartz, Mark H Ginsberg, MD Cooper, ML Motti, NC Henderson, R Zent, Raphael Ruppert, RC Rickert, Reinhard Fässler, RK Assoian, RO Hynes, Robert C Rickert, RT Abraham, SG Tangye, SJ Fleire, T Lammermann, T Uinuk-Ool, TN Sims, TT Lu, Y Shimizu   +56 more
core   +2 more sources

Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes

Journal for ImmunoTherapy of Cancer, 2019
Background The role of tumor-infiltrating B-cells (TIBs) and intratumorally-produced antibodies in cancer-immunity interactions essentially remains terra incognita.
O. I. Isaeva, G. V. Sharonov, E. O. Serebrovskaya, M. A. Turchaninova, A. R. Zaretsky, M. Shugay, D. M. Chudakov   +6 more
doaj   +1 more source

Measles-induced immune amnesia and its effects in concurrent epidemics [PDF]

, 2021
It has been recently discovered that the measles virus can wipe out the adaptive immune system, destroying B lymphocytes and reducing the diversity of non-specific B cells of the infected host. In particular, this implies that previously acquired immunization from vaccination or direct exposition to other pathogens could be erased in a phenomenon named
arxiv   +1 more source

Livestock abundance predicts vampire bat demography, immune profiles, and bacterial infection risk [PDF]

, 2018
Human activities create novel food resources that can alter wildlife–pathogen interactions. If resources amplify or dampen, pathogen transmission probably depends on both host ecology and pathogen biology, but studies that measure responses to ...
Altizer, Sonia, Becker, Daniel, Bentz, Alexandra B., Camus, Melinda S., Carrera, Jorge E., Chizhikov, Vladimir E., Czirjak, Gabor A., Fenton, M. Brock, Gilbert, Amy T., Navara, Kristen J., Recuenco, Sergio E., Simmons, Nancy B., Streicker, Daniel, Volokhov, Dmitriy V.   +13 more
core   +3 more sources

Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs

eLife, 2020
The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4+ T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptors (TCRs).
Sofya A Kasatskaya, Kristin Ladell, Evgeniy S Egorov, Kelly L Miners, Alexey N Davydov, Maria Metsger, Dmitry B Staroverov, Elena K Matveyshina, Irina A Shagina, Ilgar Z Mamedov, Mark Izraelson, Pavel V Shelyakin, Olga V Britanova, David A Price, Dmitriy M Chudakov   +14 more
doaj   +1 more source

Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood

Frontiers in Immunology, 2021
T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In this work, we analyzed this subset for NKG2C expression. In both CD56+ and CD56− subsets most of the NKG2C+ T cells had a phenotype of
Elena I. Kovalenko, Ivan V. Zvyagin, Maria A. Streltsova, Artem I. Mikelov, Artem I. Mikelov, Sofya A. Erokhina, William G. Telford, Alexander M. Sapozhnikov, Yury B. Lebedev   +8 more
doaj   +1 more source