Results 51 to 60 of about 5,026,401 (367)
Telomere and adaptive immunity [PDF]
Mechanisms of Ageing and Development, 2008 The adaptive immune response relies on the ability of lymphocytes to undergo periodic massive expansion. It is an enigma how lymphocytes are able to undergo this seemingly unlimited number of cell divisions. Telomeres and telomerase play a critical role in regulation of the replicative lifespan of cells, providing a potential mechanism which ...
openaire +2 more sources
Regulatory T Cells Beyond Autoimmunity: From Pregnancy to Cancer and Cardiovascular Disease
Frontiers in Immunology, 2020 The evolution of the full range of functions of regulatory T cells (Treg) coincides with the evolution of mammalian pregnancy. Accordingly, Treg function has been shown to be crucial for maternal-fetal tolerance and implantation. As reproduction is a key
Elisa Martini +6 more
doaj +1 more source
Evolution and function of interleukin-4 receptor signaling in adaptive immunity and neutrophils
Genes and Immunity, 2020 The cytokines interleukin (IL)-4 and IL-13, signaling via the IL-4 receptor (IL-4R), orchestrate type 2 immunity to helminth infections and toxins. Activation of epithelial and myeloid cells, and a transient neutrophils influx initiates type 2 immune ...
L. Heeb, C. Egholm, O. Boyman
semanticscholar +1 more source
Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity [PDF]
, 2017 Indexación: Web of Science; Scopus.The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide.
Alexis M. Kalergis +9 more
core +2 more sources
PLoS Biology, 2004 The ongoing battle between hosts and pathogens has long been of interest to evolutionary biologists.
openaire +4 more sources
Method for identification of condition-associated public antigen receptor sequences
eLife, 2018 Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease ...
Mikhail V Pogorelyy +6 more
doaj +1 more source
Development and function of protective and pathologic memory CD4 T cells [PDF]
, 2015 Immunological memory is one of the defining features of the adaptive immune system. As key orchestrators and mediators of immunity, CD4 T cells are central to the vast majority of adaptive immune responses.
Jaigirdar, Shafqat Ahrar +1 more
core +3 more sources
To TRIM the Immunity: From Innate to Adaptive Immunity
Frontiers in Immunology, 2020 The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in various biological processes, especially in regulating a wide range of signaling pathways involved in immune responses.
Wenyong Yang +3 more
semanticscholar +1 more source
Journal of Cachexia, Sarcopenia and Muscle, 2022 Background Cytochrome P450 4F3 (CYP4F3) is an ω‐hydroxylase that oxidizes leukotriene B4 (LTB4), prostaglandins, and fatty acid epoxides. LTB4 is synthesized by leukocytes and acts as a chemoattractant for neutrophils, making it an essential component of
Elien Smeets +18 more
doaj +1 more source
eLife, 2023 Inhibitory CD4+ T cells have been linked with suboptimal immune responses against cancer and pathogen chronicity. However, the mechanisms that underpin the development of these regulatory cells, especially in the context of ongoing antigen exposure, have
Mathew Clement +16 more
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