Results 51 to 60 of about 274,536 (135)

Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity

Nature Communications
Tumor infiltration by XCR1⁺ conventional dendritic cells (cDC1) correlates strongly with favorable prognosis and improved responses to immunotherapy. Yet, tumor-driven immunosuppressive programs restrict efficient cDC1 recruitment, highlighting the need ...
Louise Gorline, Fillipe Luiz Rosa do Carmo, Pierre Bourdely, Jérémie Bornères, Nathan Vaudiau, Aurélie Semervil, Mathias Vetillard, Aboubacar Sidiki K Coulibaly, Natacha Jugniot, Agathe Ok, Mathilde Bausart, Oriane Fiquet, Marine Andrade, Dicken Fardol, Ikrame Haddar, Zeina Abou Nader, Judith Weber, Hannah Theobald, Matthieu Collin, Joseph Calmette, Giorgio Anselmi, Flavia Fico, Florent Ginhoux, Laleh Majlessi, Emmanuel L. Gautier, Loredana Saveanu, Julie Helft, Marc Dalod, Mathilde Dusseaux, James P. Di Santo, Stéphanie Hugues, Pierre Guermonprez   +31 more
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Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients

Nature Communications, 2019
Here, the authors characterize immunological and microbiome alterations in a cohort of obese asthmatics, finding that disease severity negatively correlates with fecal abundance of Akkermansia muciniphila, and show in a mouse model that administration of
David Michalovich, Noelia Rodriguez-Perez, Sylwia Smolinska, Michal Pirozynski, David Mayhew, Sorif Uddin, Stephanie Van Horn, Milena Sokolowska, Can Altunbulakli, Andrzej Eljaszewicz, Benoit Pugin, Weronika Barcik, Magdalena Kurnik-Lucka, Ken A. Saunders, Karen D. Simpson, Peter Schmid-Grendelmeier, Ruth Ferstl, Remo Frei, Noriane Sievi, Malcolm Kohler, Pawel Gajdanowicz, Katrine B. Graversen, Katrine Lindholm Bøgh, Marek Jutel, James R. Brown, Cezmi A. Akdis, Edith M. Hessel, Liam O’Mahony   +27 more
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HBV-Specific Adaptive Immunity

Viruses, 2009
The successful control of HBV infection requires an efficient expansion of distinct elements of the adaptive immune system (B cells, helper and cytotoxic T cells) that, due to the hepatotropic nature of HBV, need to operate in the liver parenchyma.
Adam J. Gehring, Antonio Bertoletti, Anthony T. Tan   +2 more
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Adaptive immunity or evolutionary adaptation? Transgenerational immune systems at the crossroads

Biology & Philosophy, 2022
AbstractIn recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive immune system. Particularly the discovery of CRISPR-Cas9-based systems has triggered a discussion about how to classify adaptive ...
openaire   +3 more sources

Trained Immunity and its Role in Health and Diseases: A Review [PDF]

Indian Journal of Medical Biochemistry
The term immunity mostly refers to adaptive immunity, even though innate immunity also plays a crucial role. Immunological memory is the key feature distinguishing adaptive immunity from innate immunity.
Santosh Kumar Gupta
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CMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans

EMBO Reports
The transmembrane protein CMTM6 promotes plasma membrane expression of the immune checkpoint protein PD-L1, a key suppressor of anti-tumor immunity. Targeting CMTM6 has been proposed as a strategy to enhance tumor cell killing by reducing PD-L1 surface ...
Tereza Semberova, Michaela Pribikova, Veronika Cimermanova, Tijana Trivic, Rafik Haderbache, Darina Paprckova, Luca Christen, Helena Kissiova, Ondrej Stepanek, Peter Draber   +9 more
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Aberrant adaptive immune response underlies genetic susceptibility to tuberculosis

Frontiers in Immunology
Mycobacterium tuberculosis (Mtb) remains a major threat worldwide, although only a fraction of infected individuals develops tuberculosis (TB). TB susceptibility is shaped by multiple genetic factors, and we performed comparative immunological analysis ...
Anastasiia Tsareva, Pavel V. Shelyakin, Pavel V. Shelyakin, Irina A. Shagina, Irina A. Shagina, Mikhail Yu. Myshkin, Ekaterina M. Merzlyak, Ekaterina M. Merzlyak, Valeriia V. Kriukova, Alexander S. Apt, Irina A. Linge, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Olga V. Britanova, Olga V. Britanova, Olga V. Britanova   +17 more
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Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq

Frontiers in Immunology
IntroductionThe functional programs of CD4+ T helper (Th) cell clones play a central role in shaping immune responses to different challenges. While advances in single-cell RNA sequencing (scRNA-Seq) have significantly improved our understanding of the ...
Daniil K. Lukyanov, Daniil K. Lukyanov, Valeriia V. Kriukova, Kristin Ladell, Irina A. Shagina, Irina A. Shagina, Dmitry B. Staroverov, Dmitry B. Staroverov, Bella E. Minasian, Anna S. Fedosova, Pavel Shelyakin, Oleg N. Suchalko, Alexander Y. Komkov, Konstantin A. Blagodatskikh, Kelly L. Miners, Olga V. Britanova, Olga V. Britanova, Olga V. Britanova, Andre Franke, David A. Price, David A. Price, Dmitry M. Chudakov, Dmitry M. Chudakov, Dmitry M. Chudakov, Dmitry M. Chudakov, Dmitry M. Chudakov   +25 more
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Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations

Frontiers in Immunology
BackgroundT cells play a crucial role in the adaptive immune response against acute virus infections. The extensive diversity of T cell receptors (TCRs) presents a complex challenge for understanding its implications in immune responses.
Maria A. Salnikova, Maria A. Salnikova, Maria A. Salnikova, Ksenia K. Tuchynskaya, Anastasia A. Minervina, Mikhail V. Pogorelyy, Egor V. Okhezin, Galina G. Karganova, Galina G. Karganova, Ilgar Z. Mamedov, Yuri B. Lebedev, Yuri B. Lebedev   +11 more
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Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes

ImmunoTargets and Therapy, 2017
Arata Itoh, William M Ridgway Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA Abstract: Type 1 diabetes (T1D) is characterized by specific destruction of pancreatic insulin-producing ...
Itoh A, Ridgway WM
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