Results 51 to 60 of about 5,085,110 (360)

Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity [PDF]

, 2017
Indexación: Web of Science; Scopus.The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide.
Alexis M. Kalergis, Alexis M. Kalergis, Claudia A. Riedel, Emma Rey-Jurado, Gisela Canedo-Marroquín, Juan M. Saavedra, Margarita K. Lay, Margarita K. Lay, Orlando Acevedo-Acevedo, Susan M. Bueno   +9 more
core   +2 more sources

Smoking changes adaptive immunity with persistent effects

Nature
Individuals differ widely in their immune responses, with age, sex and genetic factors having major roles in this inherent variability1–6. However, the variables that drive such differences in cytokine secretion—a crucial component of the host response ...
Violaine Saint-André, B. Charbit, Anne Biton, V. Rouilly, C. Posseme, Anthony Bertrand, M. Rotival, Jacob Bergstedt, E. Patin, Matthew L. Albert, L. Quintana-Murci, Darragh Duffy, Laurent Andres Hugues Philippe Nollaig Petter Pierre Nadin Abel Alcover Aschard Bousso Bourke Brodin Bruhns C, L. Abel, Andrés Alcover, H. Aschard, Philippe Bousso, Nollaig M. Bourke, P. Brodin, Pierre Bruhns, Nadine Cerf-Bensussan, A. Cumano, Christophe d’Enfert, C. Demangel, L. Deriano, M. Dillies, James P. Di Santo, G. Eberl, J. Enninga, J. Fellay, Ivo Gomperts-Boneca, Milena Hasan, Gunilla Karlsson Hedestam, Serge Hercberg, Molly A. Ingersoll, Olivier Lantz, Rose Anne Kenny, M. Ménager, Frédérique Michel, Hugo Mouquet, Cliona O'Farrelly, A. Rausell, F. Rieux-Laucat, Lars Rogge, Magnus Fontes, A. Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer L. Shorte, Frédéric Tangy, A. Toubert, M. Touvier, M. Ungeheuer, Christophe Zimmer   +53 more
semanticscholar   +1 more source

Evolution and function of interleukin-4 receptor signaling in adaptive immunity and neutrophils

Genes and Immunity, 2020
The cytokines interleukin (IL)-4 and IL-13, signaling via the IL-4 receptor (IL-4R), orchestrate type 2 immunity to helminth infections and toxins. Activation of epithelial and myeloid cells, and a transient neutrophils influx initiates type 2 immune ...
L. Heeb, C. Egholm, O. Boyman
semanticscholar   +1 more source

BBSome-deficient cells activate intraciliary CDC42 to trigger actin-dependent ciliary ectocytosis

EMBO Reports
Bardet-Biedl syndrome (BBS) is a pleiotropic ciliopathy caused by dysfunction of the BBSome, a cargo adaptor essential for export of transmembrane receptors from cilia.
Avishek Prasai, Olha Ivashchenko, Kristyna Maskova, Sofiia Bykova, Marketa Schmidt Cernohorska, Ondrej Stepanek, Martina Huranova   +6 more
doaj   +1 more source

Innate and Adaptive Immunity in Fish: A Review

مجلة الانبار للعلوم البيطرية, 2020
The fish inhabitant in an aquatic environment so it persists exposure to pathogen and stressor factors so they have a developing immune system similar to that in high vertebrate with some differences points.
Mustafa, Enas, AL-Taee, Shahbaa
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

ABIN1 is a negative regulator of effector functions in cytotoxic T cells

EMBO Reports
T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by the T-cell antigen ...
Sarka Janusova, Darina Paprckova, Juraj Michalik, Valeria Uleri, Ales Drobek, Eva Salyova, Louise Chorfi, Ales Neuwirth, Arina Andreyeva, Jan Prochazka, Radislav Sedlacek, Peter Draber, Ondrej Stepanek   +12 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

To TRIM the Immunity: From Innate to Adaptive Immunity

Frontiers in Immunology, 2020
The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in various biological processes, especially in regulating a wide range of signaling pathways involved in immune responses.
Wenyong Yang, Zhiwen Gu, Huiyuan Zhang, Hongbo Hu   +3 more
semanticscholar   +1 more source

A Framework for Annotation of Antigen Specificities in High-Throughput T-Cell Repertoire Sequencing Studies

Frontiers in Immunology, 2019
Recently developed molecular methods allow large-scale profiling of T-cell receptor (TCR) sequences that encode for antigen specificity and immunological memory of these cells.
Mikhail V. Pogorelyy, Mikhail V. Pogorelyy, Mikhail Shugay, Mikhail Shugay, Mikhail Shugay   +4 more
doaj   +1 more source