Results 41 to 50 of about 33,819 (267)

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells [PDF]

, 2015
Cytotoxic lymphocytes share the presence of the activating receptor NK receptor group 2, member D (NKG2D) and the signaling-competent adaptor DNAX-activating protein 10 (DAP10), which together play an important role in antitumor immune surveillance ...
CAPUANO, CRISTINA, CIPPITELLI, Marco, FIONDA, Cinzia, GALANDRINI, Ricciarda, MOLFETTA, Rosa, PAOLINI, Rossella, PERUZZI, Giovanna, QUATRINI, LINDA, SANTONI, Angela, ZITTI, BEATRICE   +9 more
core   +1 more source

Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes

Biology Direct, 2011
Background Mammalian genome sequence data are being acquired in large quantities and at enormous speeds. We now have a tremendous opportunity to better understand which genes are the most variable or conserved, and what their particular functions and ...
Wang Lei, Liu Fei, Wang Dapeng, Huang Shi, Yu Jun   +4 more
doaj   +1 more source

Future therapeutic strategies: Implications for Brk targeting [PDF]

, 2011
The official published article can be found at the link below - Copyright @ 2011 InTech. This Article has been provided by the Brunel Open Access Publishing Fund.Rajpal Burmi was supported by a Breast Cancer Campaign project ...
Burmi, RS, Harvey, AJ
core   +2 more sources

The Role of Signal-Transducing Adaptor Protein-2 in Early T Lymphopoiesis in Thymus

Blood, 2014
Abstract Immune cells show quick responses to infection. Many studies concerning cellular and humoral immunity have focused on the regulation of mature lymphocyte function. However, recent studies revealed that the early stage of hematopoiesis plays an important role in the immune system.
Michiko Ichii, Natsuko Fujita, Daisuke Okuzaki, Tetsuo Maeda, Yuichi Sekine, Shigeyuki Kon, Ryuta Muromoto, Kenji Oritani, Tadashi Matsuda, Yuzuru Kanakura   +9 more
openaire   +1 more source

The Adaptor Protein Paxillin Is Essential for Normal Development in the Mouse and Is a Critical Transducer of Fibronectin Signaling [PDF]

Molecular and Cellular Biology, 2002
The integrin family of cell adhesion receptors are important for a diverse set of biological responses during development. Although many integrins have been shown to engage a similar set of cytoplasmic effector proteins in vitro, the importance of these proteins in the biological events mediated by different integrin receptors and ligands is uncertain.
Margit, Hagel, Elizabeth L, George, Ann, Kim, Rulla, Tamimi, Sarah L, Opitz, Christopher E, Turner, Akira, Imamoto, Sheila M, Thomas   +7 more
openaire   +2 more sources

TCR triggering induces the formation of Lck-RACK1-actinin-1 multiprotein network affecting Lck redistribution

Frontiers in Immunology, 2016
The initiation of T-cell signaling is critically dependent on the function of the member of Src family tyrosine kinases (SFKs), Lck. Upon TCR triggering, Lck kinase activity induces the nucleation of signal-transducing hubs that regulate the formation of
Ondrej Ballek, Jan Valečka, Martina Dobešová, Adéla Broučková, Jasper Manning, Pavel Řehulka, Jiří Stulík, Dominik Filipp   +7 more
doaj   +1 more source

Functional characterization of a short peptidoglycan recognition protein from Chinese giant salamander (Andrias davidianus) [PDF]

, 2017
This work was supported by the National Natural Science Foundation of China (Grant no. 31302221, 31172408 and 31272666) and Jiangsu Province (Grant no.
Chang, Mingxian, Nie, Pin, Qi, Zhitao, Qiao, Guo, Ren, Shisi, Wang, Zisheng, Xu, Qiaoqing, Zhang, Qihuan, Zou, Jun   +8 more
core   +1 more source

TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding

PLoS ONE, 2011
The receptor for advanced glycation end products (RAGE) is thought to be involved in the pathogenesis of a broad range of inflammatory, degenerative and hyperproliferative diseases. It binds to diverse ligands and activates multiple intracellular signaling pathways.
Masakiyo Sakaguchi, Hitoshi Murata, Ken-ichi Yamamoto, Tomoyuki Ono, Yoshihiko Sakaguchi, Akira Motoyama, Toshihiko Hibino, Ken Kataoka, Nam-ho Huh   +8 more
openaire   +4 more sources

Ubiquitination in Control of EGF Receptor Endocytosis [PDF]

, 2008
Growth factors and growth factor receptors comprise a signaling network regulating cell differentiation and growth. Tightly regulation of this network is important to avoid excessive signaling and cell growth, which may result in cancer.
Bertelsen, Vibeke
core   +1 more source

Hrs, a Mammalian Master Molecule in Vesicular Transport and Protein Sorting, Suppresses the Degradation of ESCRT Proteins Signal Transducing Adaptor Molecule 1 and 2 [PDF]

Journal of Biological Chemistry, 2005
The degradation and sorting of cytoplasmic and cell-surface proteins are crucial steps in the control of cellular functions. We previously identified three mammalian Vps (vacuolar protein sorting) proteins, Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and signal transducing adaptor molecule (STAM) 1 and -2, which are tyrosine ...
Hideyuki, Kobayashi, Nobuyuki, Tanaka, Hironobu, Asao, Shigeto, Miura, Masanao, Kyuuma, Kayoko, Semura, Nobuhisa, Ishii, Kazuo, Sugamura   +7 more
openaire   +2 more sources