Results 1 to 10 of about 42,601 (251)

Adar contributes to genome integrity by regulating R-loop homeostasis in Drosophila [PDF]

BMC Biology
Background Adenosine deaminase acting on RNA (Adar) is a critical enzyme involved in post-transcriptional epigenetic regulation through adenosine-to-inosine (A-to-I) RNA editing.
Xuedi Zhang, Hongyun Liu, Ju Peng, Guangbin Wang, Xiangyu Wu, Shuai Li, Jie Zheng, Qianwen Sun, Guanjun Gao   +8 more
doaj   +4 more sources

An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing [PDF]

Nature Communications
Custom RNA base editing exploiting the human Adenosine Deaminase Acting on RNA (ADAR) enzyme may enable therapeutic gene editing without DNA damage or use of foreign proteins.
Susan M. Byrne, Stephen M. Burleigh, Robert Fragoza, Yue Jiang, Yiannis Savva, Ricky Pabon, Evan Kania, Joseph Rainaldi, Andrew Portell, Prashant Mali, Adrian W. Briggs   +10 more
doaj   +4 more sources

Identification and Spatiotemporal Expression of Adenosine Deaminases Acting on RNA (ADAR) during Earthworm Regeneration: Its Possible Implication in Muscle Redifferentiation [PDF]

Biology, 2020
Adenosine deaminases acting on RNA (ADAR) catalyze the hydrolytic deamination of adenosine (A) to produce inosine (I) in double-stranded RNA substrates.
Yoo Bin Yoon, Yun-Sang Yu, Beom Jun Park, Sung-Jin Cho, Soon Cheol Park   +4 more
doaj   +2 more sources

A loss-of-function human ADAR variant activates innate immune response and promotes bowel inflammation [PDF]

Nature Communications
Inflammatory bowel disease (IBD) arises from genetic-environmental interactions. Adenosine deaminases acting on RNA 1 (ADAR), an RNA-editing enzyme converting adenosine (A) to inosine (I), is essential for tissue homeostasis.
Pengfei Xu, Yue Xi, Jong-Won Kim, Min Zhang, Chen Gao, Yue Wang, Meishu Xu, Xingchen Wang, Songrong Ren, Da Yang, Qingde Wang, Wen Xie   +11 more
doaj   +2 more sources

Abundant A-to-I RNA editing in spermatocytes may suppress transposons to compensate for piRNA downregulation in male germlines [PDF]

RNA Biology
The germline genome serves as a crucial battleground for transposon expansion, as transposons can increase their copy numbers in offspring when activated within germ cells.
Yuange Duan, Qiuhua Xie, Ling Ma, Qi Cao
doaj   +2 more sources

Systematic analysis of A-to-I RNA editing upon release of ADAR from the nucleolus [PDF]

RNA Biology
Adenosine-to-inosine (A-to-I) RNA editing, catalysed by two ADAR isoforms (p110 and p150) and ADARB1, is a critical regulatory step in gene expression.
Ruben Lattuca, Rümeyza Bascetin, Vincent Detours, Denis L. J. Lafontaine   +3 more
doaj   +2 more sources

Tripartite motif 47 promotes the development of thyroid carcinoma through ADAR ubiquitination [PDF]

Molecular Medicine
Background Tripartite motif 47 (TRIM47) plays a vital role in the carcinogenesis and drug resistance of various cancers, whereas the function of TRIM47 in thyroid carcinoma (TC) remains unclear.
Hongzhou Liu, Xiaodong Hu, Tan Li, Yuhan Wang, Xiaomin Fu   +4 more
doaj   +2 more sources

Phylogenetic and structural analysis of Hydra ADAR

Archives of Biochemistry and Biophysics
Adenosine deaminases acting on RNAs (ADARs) perform adenosine-to-inosine (A-to-I) RNA editing for essential biological functions. While studies of editing sites in diverse animals have revealed unique biological roles of ADAR editing including temperature adaptation and reproductive maturation, rigorous biochemical and structural studies of these ADARs
Xander E. Wilcox, Heng Zhang, Jasmine L. Mah, Jack F. Cazet, Sukanya Mozumder, Srinidhi Venkatesh, Celina E. Juliano, Peter A. Beal, Andrew J. Fisher   +8 more
openalex   +4 more sources

ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression

Cell Reports, 2013
Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells.
Isabel X. Wang, Elizabeth So, James L. Devlin, Yue Zhao, Ming Wu, Vivian G. Cheung   +5 more
doaj   +2 more sources

ADAR Family Proteins: A Structural Review

Current Issues in Molecular Biology
This review aims to highlight the structures of ADAR proteins that have been crucial in the discernment of their functions and are relevant to future therapeutic development.
Carolyn N. Ashley, Emmanuel Broni, Whelton A. Miller   +2 more
doaj   +3 more sources