Results 1 to 10 of about 42,221 (215)
Biology, 2020 Adenosine deaminases acting on RNA (ADAR) catalyze the hydrolytic deamination of adenosine (A) to produce inosine (I) in double-stranded RNA substrates.
Yoo Bin Yoon +4 more
doaj +1 more source
ADAR expression and copy number variation in patients with advanced gastric cancer
BMC Gastroenterology, 2020 Background Gastric cancer (GC) is a world health problem and it is the third leading cause of cancer deaths worldwide. The current practice for prognosis assessment in GC is based on radiological and pathological criteria and they may not result in an ...
Javad Behroozi +3 more
doaj +1 more source
The A to I editing landscape in melanoma and its relation to clinical outcome
RNA Biology, 2022 RNA editing refers to non-transient RNA modifications that occur after transcription and prior to translation by the ribosomes. RNA editing is more widespread in cancer cells than in non-transformed cells and is associated with tumorigenesis of various ...
Austeja Amweg +11 more
doaj +1 more source
Dynamic hyper-editing underlies temperature adaptation in Drosophila. [PDF]
PLoS Genetics, 2017 In Drosophila, A-to-I editing is prevalent in the brain, and mutations in the editing enzyme ADAR correlate with specific behavioral defects. Here we demonstrate a role for ADAR in behavioral temperature adaptation in Drosophila.
Ilana Buchumenski +6 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 RNA editing holds great promise for the therapeutic correction of pathogenic, single nucleotide variants (SNV) in the human transcriptome since it does not risk creating permanent off-targets edits in the genome and has the potential for innovative ...
Julia-Sophia Bellingrath +5 more
doaj +1 more source
The Advantage of Evidential Attributes in Social Networks [PDF]
, 2017 Nowadays, there are many approaches designed for the task of detecting communities in social networks. Among them, some methods only consider the topological graph structure, while others take use of both the graph structure and the node attributes.
adar +7 more
core +3 more sources
BMC Biology, 2020 Background In fly brains, the Drosophila Adar (adenosine deaminase acting on RNA) enzyme edits hundreds of transcripts to generate edited isoforms of encoded proteins.
Anzer Khan +8 more
doaj +1 more source
Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons
Cell Reports, 2020 Summary: Adenosine-to-inosine RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, alters RNA sequences from those encoded by DNA. These editing events are dynamically regulated, but few trans regulators of ADARs are known in vivo.
Anne L. Sapiro +8 more
doaj +1 more source
Global Medical Genetics, 2023 Interferon (IFN)-β is the first-line disease management choice in multiple sclerosis (MS) with profound effects; however, in up to 50% of patients, clinical response does not occur.
Fakhr Fakhr +6 more
doaj +1 more source
DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]
, 2017 Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A +2 more
core +1 more source