ADAR Family Proteins: A Structural Review
Current Issues in Molecular BiologyThis review aims to highlight the structures of ADAR proteins that have been crucial in the discernment of their functions and are relevant to future therapeutic development.
Carolyn N. Ashley +2 more
doaj +4 more sources
Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs [PDF]
Genome Biology, 2017 One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes.
Carl R. Walkley, Jin Billy Li
doaj +7 more sources
Aicardi-Goutières syndrome type 6: report of ADAR variant and clinical outcome after ruxolitinib treatment in the neonatal period [PDF]
Pediatric Rheumatology Online JournalBackground Aicardi-Goutières Syndrome is a monogenic type 1 interferonopathy with infantile onset, characterized by a variable degree of neurological damage.
Alba Gabaldon-Albero +12 more
doaj +3 more sources
Identification and Spatiotemporal Expression of Adenosine Deaminases Acting on RNA (ADAR) during Earthworm Regeneration: Its Possible Implication in Muscle Redifferentiation [PDF]
Biology, 2020 Adenosine deaminases acting on RNA (ADAR) catalyze the hydrolytic deamination of adenosine (A) to produce inosine (I) in double-stranded RNA substrates.
Yoo Bin Yoon +4 more
doaj +2 more sources
New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins [PDF]
Biomolecules, 2015 The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Niamh Mannion +4 more
doaj +4 more sources
Frontiers in Molecular Neuroscience, 2023 RNA editing holds great promise for the therapeutic correction of pathogenic, single nucleotide variants (SNV) in the human transcriptome since it does not risk creating permanent off-targets edits in the genome and has the potential for innovative ...
Julia-Sophia Bellingrath +5 more
doaj +2 more sources
The role of distinct APOBEC/ADAR mRNA levels in mutational signatures linked to aging and ultraviolet radiation [PDF]
Scientific ReportsThe APOBEC/AID family is known for its mutator activity, and recent evidence also supports the potential impact of ADARs. Furthermore, the mutator impacts of APOBEC/ADAR mutations have not yet been investigated.
Ahmadreza Niavarani
doaj +3 more sources
RNA Biology, 2023 Adenosine-to-inosine (A-to-I) RNA editing, mediated by metazoan ADAR enzymes, is a prevalent post-transcriptional modification that diversifies the proteome and promotes adaptive evolution of organisms. The Drosophila Adar gene has an auto-recoding site (
Ling Ma +8 more
doaj +2 more sources
Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections
BMC Genomics, 2023 Background RNA editing is a process that increases transcriptome diversity, often through Adenosine Deaminases Acting on RNA (ADARs) that catalyze the deamination of adenosine to inosine.
Benjamin Wales-McGrath +2 more
doaj +2 more sources
Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR. [PDF]
PLoS ONETherapeutic targeting of the adenosine deaminase ADAR has great potential in cancer and other indications; however, it remains unclear what approach can enable effective and selective therapeutic inhibition.
Benjamin G Gowen +12 more
doaj +2 more sources