Aicardi-Goutières syndrome type 6: report of ADAR variant and clinical outcome after ruxolitinib treatment in the neonatal period [PDF]
Pediatric Rheumatology Online JournalBackground Aicardi-Goutières Syndrome is a monogenic type 1 interferonopathy with infantile onset, characterized by a variable degree of neurological damage.
Alba Gabaldon-Albero +12 more
doaj +3 more sources
VIRMA promotes NSCLC progression by modifying ADAR m6A and increasing the activity of the TGF-β signaling pathway [PDF]
Scientific ReportsThe N6-methyladenosine (m6A) modification is prevalently found in mRNAs and lncRNAs in various eukaryotic organisms, playing a crucial role in biological processes.
Yuchen Shan +8 more
doaj +3 more sources
The role of distinct APOBEC/ADAR mRNA levels in mutational signatures linked to aging and ultraviolet radiation [PDF]
Scientific ReportsThe APOBEC/AID family is known for its mutator activity, and recent evidence also supports the potential impact of ADARs. Furthermore, the mutator impacts of APOBEC/ADAR mutations have not yet been investigated.
Ahmadreza Niavarani
doaj +3 more sources
Identification and Spatiotemporal Expression of Adenosine Deaminases Acting on RNA (ADAR) during Earthworm Regeneration: Its Possible Implication in Muscle Redifferentiation [PDF]
Biology, 2020 Adenosine deaminases acting on RNA (ADAR) catalyze the hydrolytic deamination of adenosine (A) to produce inosine (I) in double-stranded RNA substrates.
Yoo Bin Yoon +4 more
doaj +2 more sources
Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR. [PDF]
PLoS ONETherapeutic targeting of the adenosine deaminase ADAR has great potential in cancer and other indications; however, it remains unclear what approach can enable effective and selective therapeutic inhibition.
Benjamin G Gowen +12 more
doaj +2 more sources
Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs [PDF]
Genome Biology, 2017 One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes.
Carl R. Walkley, Jin Billy Li
doaj +2 more sources
QCD3 dualities and the F-theorem [PDF]
Journal of High Energy Physics, 2018 There has recently been a surge of new ideas and results for 2+1 dimensional gauge theories. We consider a recently proposed duality for 2+1 dimensional QCD, which predicts a symmetry-breaking phase.
Adar Sharon
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Charting and probing the activity of ADARs in human development and cell-fate specification [PDF]
Nature CommunicationsAdenosine deaminases acting on RNA (ADARs) impact diverse cellular processes and pathological conditions, but their functions in early cell-fate specification remain less understood.
Amir Dailamy +10 more
doaj +2 more sources
A-to-I-Edited miR-1304-3p Inhibits Glycolysis and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inactivating Wnt5a/ROR2 Signaling. [PDF]
Mol CarcinogABSTRACT A‐to‐I RNA editing is a pervasive mechanism in the human genome that affects the regulation of gene expression and is closely associated with the pathogenesis of numerous diseases. This study elucidates the regulatory mechanism of A‐to‐I edited miR‐1304‐3p in esophageal squamous cell carcinoma (ESCC). Western blot, immunohistochemistry, and RT‐
Chen P +8 more
europepmc +2 more sources
Detecting haplotype-specific transcript variation in long reads with FLAIR2 [PDF]
Genome BiologyBackground RNA-seq has brought forth significant discoveries regarding aberrations in RNA processing, implicating these RNA variants in a variety of diseases.
Alison D. Tang +5 more
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