Results 91 to 100 of about 42,221 (215)

A-to-I editing of Malacoherpesviridae RNAs supports the antiviral role of ADAR1 in mollusks

BMC Evolutionary Biology, 2019
Background Adenosine deaminase enzymes of the ADAR family are conserved in metazoans. They convert adenine into inosine in dsRNAs and thus alter both structural properties and the coding potential of their substrates.
Umberto Rosani, Chang-Ming Bai, Lorenzo Maso, Maxwell Shapiro, Miriam Abbadi, Stefania Domeneghetti, Chong-Ming Wang, Laura Cendron, Thomas MacCarthy, Paola Venier   +9 more
doaj   +1 more source

On Einstein equations on manifolds and supermanifolds

, 2002
The Einstein equations (EE) are certain conditions on the Riemann tensor on the real Minkowski space M. In the twistor picture, after complexification and compactification M becomes the Grassmannian $Gr_{2}^{4}$ of 2-dimensional subspaces in the 4 ...
Leites, D., Poletaeva, E., Serganova, V.
core   +2 more sources

Amblyomma cajennense Sensu Stricto (Fabricius, 1787) and Amblyomma sculptum (Berlese, 1888) Tick Saliva Elicit Immune‐Modulatory Activity in Isolated Murine Macrophages With an Insight Into Proteomic Analysis

Parasite Immunology, Volume 48, Issue 3, March 2026.
ABSTRACT Tick saliva is known to cause immunosuppression and help pathogen transmission. Amblyomma sculptum is a public health concern as a vector of Rickettsia rickettsii. Another close‐related species is Amblyomma cajennense sensu stricto (s.s.). The impact of saliva from these species on murine macrophages remains unclear.
André de Abreu Rangel Aguirre, Valdison Pereira dos Reis, Sulamita da Silva Setúbal, Angélica Lorena Pereira Mendes Carioca, Ketlei Monteiro Tavares, Geisa Paulino Caprini Evaristo, Joseph Albert Medeiros Evaristo, Fábio César Sousa Nogueira, Jansen Fernandes Medeiros, Juliana Pavan Zuliani   +9 more
wiley   +1 more source

Evidence for transcriptome-wide RNA editing among Sus scrofa PRE-1 SINE elements

BMC Genomics, 2017
Background RNA editing by ADAR (adenosine deaminase acting on RNA) proteins is a form of transcriptional regulation that is widespread among humans and other primates.
Scott A. Funkhouser, Juan P. Steibel, Ronald O. Bates, Nancy E. Raney, Darius Schenk, Catherine W. Ernst   +5 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 2, Page 409-427, February 2026.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Finding Streams in Knowledge Graphs to Support Fact Checking

, 2017
The volume and velocity of information that gets generated online limits current journalistic practices to fact-check claims at the same rate. Computational approaches for fact checking may be the key to help mitigate the risks of massive misinformation ...
Ciampaglia, Giovanni Luca, Flammini, Alessandro, Menczer, Filippo, Shiralkar, Prashant   +3 more
core   +1 more source

Charting and probing the activity of ADARs in human development and cell-fate specification

Nature Communications
Adenosine deaminases acting on RNA (ADARs) impact diverse cellular processes and pathological conditions, but their functions in early cell-fate specification remain less understood.
Amir Dailamy, Weiqi Lyu, Sami Nourreddine, Michael Tong, Joseph Rainaldi, Daniella McDonald, Rebecca Panwala, Alysson Muotri, Michael S. Breen, Kun Zhang, Prashant Mali   +10 more
doaj   +1 more source

The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis

eLife, 2017
ADAR proteins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs. Loss of ADARs affects neuronal function in all animals studied to date.
Sarah N Deffit, Brian A Yee, Aidan C Manning, Suba Rajendren, Pranathi Vadlamani, Emily C Wheeler, Alain Domissy, Michael C Washburn, Gene W Yeo, Heather A Hundley   +9 more
doaj   +1 more source

Evolving Political Accountability in Kenya [PDF]

, 2010
published or submitted for publicationnot peer ...
Jacob Butler
core  

An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

Cell Reports
Summary: Adar null mutant mouse embryos die with aberrant double-stranded RNA (dsRNA)-driven interferon induction, and Adar Mavs double mutants, in which interferon induction is prevented, die soon after birth.
Ketty Sinigaglia, Anna Cherian, Qiupei Du, Valentina Lacovich, Dragana Vukić, Janka Melicherová, Pavla Linhartova, Lisa Zerad, Stanislav Stejskal, Radek Malik, Jan Prochazka, Nadège Bondurand, Radislav Sedláček, Mary A. O’Connell, Liam P. Keegan   +14 more
doaj   +1 more source