Results 91 to 100 of about 43,703 (264)

Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]

, 2013
The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal signaling during development and in maintaining the stability of established networks in the face of altered sensory input.
Ales eBalik, Andrew Charles Penn, Andrew Charles Penn, Ingo H Greger   +3 more
core   +2 more sources

Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges

Advanced Genetics, EarlyView.
This review provides a comprehensive comparison of RNA‐ and protein‐centric methodologies for investigating RNA–protein interactions, emphasizing their respective advantages, limitations, and suitable applications. It highlights recent technological innovations, outlines strategic method selection criteria, and addresses key challenges.
Wenkai Yi, Jian Yan
wiley   +1 more source

In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. [PDF]

, 2019
We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated the
Chen, Genghao, Ganesh, Ashwin, Katrekar, Dhruva, Mali, Prashant, Meluzzi, Dario, Shih, Yu-Ru, Varghese, Shyni, Worlikar, Atharv   +7 more
core   +1 more source

Handling oversampling in dynamic networks using link prediction [PDF]

, 2015
Oversampling is a common characteristic of data representing dynamic networks. It introduces noise into representations of dynamic networks, but there has been little work so far to compensate for it. Oversampling can affect the quality of many important
A-L Barabási, J Zhu, LA Adamic, MH Hansen, N Eagle, P Baldi, P Erdős, P Holme, P Sarkar, V Freschi, Y Liu   +10 more
core   +1 more source

Using participatory scenario planning to explore the synergies and trade‐offs from upland treescape expansion

People and Nature, EarlyView.
Abstract The future of land use in the UK uplands is highly debated, with growing interest in increasing tree cover and other land use changes, alongside a desire to maintain traditional land use patterns and practices. Treescape expansion is likely to result in synergies and trade‐offs between different outcomes, so integrating stakeholder preferences
Melissa Minter, Susan Baker, Euan Bowditch, Sheena Carlisle, Natasha Constant, Alix Syder, Tom Finch   +6 more
wiley   +1 more source

Deep transcriptome profiling reveals limited conservation of A-to-I RNA editing in Xenopus

BMC Biology, 2023
Background Xenopus has served as a valuable model system for biomedical research over the past decades. Notably, ADAR was first detected in frog oocytes and embryos as an activity that unwinds RNA duplexes. However, the scope of A-to-I RNA editing by the
Tram Anh Nguyen, Jia Wei Joel Heng, Yan Ting Ng, Rui Sun, Shira Fisher, Gokce Oguz, Pornchai Kaewsapsak, Shifeng Xue, Bruno Reversade, Adaikalavan Ramasamy, Eli Eisenberg, Meng How Tan   +11 more
doaj   +1 more source

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects [PDF]

, 2010
Flies with mutations in the single Drosophila Adar gene encoding an RNA editing enzyme involved in editing 4% of all transcripts have severe locomotion defects and develop age-dependent neurodegeneration.
Brindle, James, Keegan, Liam P., Li, Xianghua, McGurk, Leeane, O'Connell, Mary A., Palavicini, Juan Pablo, Paro, Simona, Rosenthal, Joshua J. C.   +7 more
core   +6 more sources

Upregulation of ADAR Promotes Breast Cancer Progression and Serves as a Potential Therapeutic Target

Journal of Oncology, 2021
Background Breast cancer (BC) is the most common cause of cancer death worldwide, and its incidence is increasing every year. This study aims to investigate the expression characteristics of ADAR gene in breast cancer and to explore its role in the ...
Xiao Li, Guangshun Sun, Liangliang Wu, Guoqiang Sun, Ye Cheng, Jing Tao, Zhouxiao Li, Weiwei Tang, Hanjin Wang   +8 more
semanticscholar   +1 more source

Editing independent effects of ADARs on the miRNA/siRNA pathways [PDF]

The EMBO Journal, 2009
Adenosine deaminases acting on RNA (ADARs) are best known for altering the coding sequences of mRNA through RNA editing, as in the GluR-B Q/R site. ADARs have also been shown to affect RNA interference (RNAi) and microRNA processing by deamination of specific adenosines to inosine.
Heale, Bret S. E., Keegan, Liam P., McGurk, Leeanne, Michlewski, Gracjan, Brindle, James, Stanton, Chloe M., Caceres, Javier F., O'Connell, Mary A.   +7 more
openaire   +5 more sources

Making moral selves through comparison: Narratives of moral decline and the modern virtuous self among middle‐class older adults in Nepal

Ethos, EarlyView.
Abstract During fieldwork among older adults in middle‐class families in the city of Bhaktapur (2018–2019), I recurrently came across comparative narratives of moral decline, depicting a stark contrast between the present time and a mythical past where ageing parents were treated “as gods.” In this paper, I analyze how, through acts of comparisons ...
Paola Tinè
wiley   +1 more source