Results 91 to 100 of about 40,794 (233)
Selective Recognition of RNA Substrates by ADAR Deaminase Domains [PDF]
Biochemistry, 2018 Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA and is catalyzed by ADAR1 and ADAR2 in humans. ADAR1 and ADAR2 have different substrate selectivity, which is believed to mainly originate from the proteins' deaminase domains (hADAR1d and hADAR2d, respectively).
Yuru Wang, SeHee Park, Peter A. Beal
openaire +5 more sources
Lessons from discovery of true ADAR RNA editing sites in a human cell line
BMC Biology, 2023 Background Conversion or editing of adenosine (A) into inosine (I) catalyzed by specialized cellular enzymes represents one of the most common post-transcriptional RNA modifications with emerging connection to disease.
Fang Wang +9 more
doaj +1 more source
The staying power of self interest: Kenya's unshakeable elites [PDF]
, 2012 Kenyan political discourse has been dominated by elites and politics of self-interest since its independence. Kenya is notorious for its levels of corruption and questionable levels of accountability.
Lower, Matthew Charles
core
Cell Proliferation, EarlyView.FAM20C regulates the composition of the YTHDC1‐NCL‐KAP1‐LINE1 RNAs complex, thereby affecting neuronal differentiation in hypoxic–ischemic brain damage (HIBD). ABSTRACT Neurodevelopmental impairment due to hypoxic–ischemic brain damage (HIBD) lacks effective biomarkers and therapeutic targets.
Chen‐xi Feng +8 more
wiley +1 more source
Folia Neuropathologica, 2016 Pathogenic molecular variants in the ADAR gene are a known cause of rare diseases, autosomal recessive Aicardi- Goutières syndrome type 6, severe infantile encephalopathy with intracranial calcifications and dominant dyschromatosis symmetrica hereditaria,
Dorota Piekutowska-Abramczuk +9 more
doaj +1 more source
Difficult‐to‐Treat Epilepsy With Developmental Implications
Annals of the Child Neurology Society, EarlyView.
Samuel Kamoroff +2 more
wiley +1 more source
Cell Proliferation, EarlyView.CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far +4 more
wiley +1 more source
A-to-I editing of Malacoherpesviridae RNAs supports the antiviral role of ADAR1 in mollusks
BMC Evolutionary Biology, 2019 Background Adenosine deaminase enzymes of the ADAR family are conserved in metazoans. They convert adenine into inosine in dsRNAs and thus alter both structural properties and the coding potential of their substrates.
Umberto Rosani +9 more
doaj +1 more source
Economics &Politics, EarlyView.ABSTRACT This study analyzes voting behavior in Türkiye's parliamentary elections from 2007 to 2023 under the rule of the Justice and Development Party (AKP), focusing on regional disparities and rising political discontent. Using province‐level data and feasible generalized least squares (FGLS) estimation with region‐specific interactions, the ...
Özge Kozal +2 more
wiley +1 more source
Tuning of RNA editing by ADAR is required in Drosophila [PDF]
The EMBO Journal, 2005 RNA editing increases during development in more than 20 transcripts encoding proteins involved in rapid synaptic neurotransmission in Drosophila central nervous system and muscle. Adar (adenosine deaminase acting on RNA) mutant flies expressing only genome-encoded, unedited isoforms of ion-channel subunits are viable but show severe locomotion defects.
Mary A O'Connell +5 more
openaire +3 more sources