Results 121 to 130 of about 43,703 (264)
Stochastic Block Models with Multiple Continuous Attributes [PDF]
, 2018 The stochastic block model (SBM) is a probabilistic model for community structure in networks. Typically, only the adjacency matrix is used to perform SBM parameter inference.
Bonacci, Thomas +4 more
core +3 more sources
Tuning of RNA editing by ADAR is required in Drosophila [PDF]
The EMBO Journal, 2005 RNA editing increases during development in more than 20 transcripts encoding proteins involved in rapid synaptic neurotransmission in Drosophila central nervous system and muscle. Adar (adenosine deaminase acting on RNA) mutant flies expressing only genome-encoded, unedited isoforms of ion-channel subunits are viable but show severe locomotion defects.
Mary A O'Connell +5 more
openaire +3 more sources
The Rare Syndrome Aicardi–Goutières 4: A Case Report and Literature Review
Developmental Neurobiology, Volume 85, Issue 2, April 2025.ABSTRACT Aicardi–Goutières syndrome (AGS) is a genetically heterogeneous type of interferonopathy resulting from defects in the processing or sensing of nucleic acids. The AGS phenotype encompasses a broad range of neurological and non‐neurological findings.
Hilal Aydin, Hilmi Bolat
wiley +1 more source
Evidence for transcriptome-wide RNA editing among Sus scrofa PRE-1 SINE elements
BMC Genomics, 2017 Background RNA editing by ADAR (adenosine deaminase acting on RNA) proteins is a form of transcriptional regulation that is widespread among humans and other primates.
Scott A. Funkhouser +5 more
doaj +1 more source
Journal of Medical Virology, Volume 97, Issue 4, April 2025.ABSTRACT We surveyed single nucleotide variant (SNV) patterns from 5 903 647 complete SARS‐CoV‐2 genomes. Among 10 012 SNVs, APOBEC‐mediated C‐to‐U (C > U) deamination was the most prevalent, followed by G > U and other RNA editing‐related substitutions including (A > G, U > C, G > A).
Xierzhatijiang Sulaiman +9 more
wiley +1 more source
Graph neural link predictor based on cycle structure
CAAI Transactions on Intelligence Technology, Volume 10, Issue 2, Page 615-632, April 2025.Abstract Currently, the link prediction algorithms primarily focus on studying the interaction between nodes based on chain structure and star structure, which predominantly rely on low‐order structural information and do not explore the multivariate interactions between nodes from the perspective of higher‐order structural information present in the ...
Yanlin Yang +4 more
wiley +1 more source
Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases
Microbiology and Immunology, Volume 69, Issue 4, Page 191-202, April 2025.ABSTRACT Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein ...
Tianli Zhang +4 more
wiley +1 more source
The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis
eLife, 2017 ADAR proteins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs. Loss of ADARs affects neuronal function in all animals studied to date.
Sarah N Deffit +9 more
doaj +1 more source
An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype
Nucleic Acids Research, 2020 The RNA-editing protein ADAR is essential for early development in the mouse. Genetic evidence suggests that A to I editing marks endogenous RNAs as ‘self’.
Prajakta Bajad +8 more
semanticscholar +1 more source
Metabolic diseases and interferon immune responses
Interdisciplinary Medicine, Volume 3, Issue 2, March 2025.This review examines the complex relationship between metabolic diseases (obesity, diabetes, and MAFLD) and interferon (IFN) immune responses. It highlights how metabolic dysregulation alters IFN signaling, affecting immune response efficiency. The review also explores how changes in IFN signaling influence the onset and progression of these diseases ...
Haiyan Zhou +3 more
wiley +1 more source