Results 141 to 150 of about 8,523 (174)

ADARs, RNA editing and more in hematological malignancies

Leukemia, 2020
Adenosine-to-inosine (A-to-I) editing is the most prevalent type of RNA editing in humans, mediated by the adenosine deaminases acting on RNA (ADARs). Physiologically, these enzymes are present in the nucleus and/or the cytoplasm, where they catalyze the conversion of adenosines (A) to inosines (I) on double-stranded mRNA molecules.
Phaik Ju Teoh, Mun Yee Koh, Wee Joo Chng
openaire   +2 more sources

Adar: Adversarial Activity Recognition in Wearables

2019 IEEE/ACM International Conference on Computer-Aided Design (ICCAD), 2019
Recent advances in machine learning and deep neural networks have led to the realization of many important applications in the area of personalized medicine. Whether it is detecting activities of daily living or analyzing images for cancerous cells, machine learning algorithms have become the dominant choice for such emerging applications.
Ramesh Kumar Sah, Hassan Ghasemzadeh 0001   +1 more
openaire   +1 more source

Artificial RNA Editing with ADAR for Gene Therapy

Current Gene Therapy, 2020
Editing mutated genes is a potential way for the treatment of genetic diseases. G-to-A mutations are common in mammals and can be treated by adenosine-to-inosine (A-to-I) editing, a type of substitutional RNA editing. The molecular mechanism of A-to-I editing involves the hydrolytic deamination of adenosine to an inosine base; this reaction is mediated
Sonali Bhakta, Toshifumi Tsukahara
openaire   +2 more sources

Editing specificity of ADAR isoforms

Adenosine to inosine deaminases acting on RNA (ADARs) enzymes are found in all metazoa. Their sequence and protein organization is conserved but also shows distinct differences. Moreover, the number of ADAR genes differs between organisms, ranging from one in flies to three in mammals.
Cornelia, Vesely, Michael F, Jantsch
openaire   +2 more sources

Modulation of MicroRNA Expression and Function by ADARs

2011
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by preventing the translation of specific messenger RNAs. Adenosine deaminases acting on RNAs (ADARs) catalyze adenosine-to-inosine (A-to-I) RNA editing, the conversion of adenosines into inosines, in double-stranded RNAs. Because inosine preferentially base pairs with cytidine,
Bjorn-Erik, Wulff, Kazuko, Nishikura
openaire   +2 more sources

Adenosine Deaminases That Act on RNA (ADARs)

2017
Inosine is one of the most common modifications found in human RNAs and the Adenosine Deaminases that act on RNA (ADARs) are the main enzymes responsible for its production. ADARs were first discovered in the 1980s and since then our understanding of ADARs has advanced tremendously.
Yuru, Wang, Yuxuan, Zheng, Peter A, Beal
openaire   +2 more sources

ADAR Proteins: Structure and Catalytic Mechanism

2011
Since the discovery of the adenosine deaminase (ADA) acting on RNA (ADAR) family of proteins in 1988 (Bass and Weintraub, Cell 55:1089-1098, 1988) (Wagner et al. Proc Natl Acad Sci U S A 86:2647-2651, 1989), we have learned much about their structure and catalytic mechanism.
Rena A, Goodman, Mark R, Macbeth, Peter A, Beal   +2 more
openaire   +2 more sources

Mouse models for understanding physiological functions of ADARs

Adenosine-to-inosine (A-to-I) editing, is a highly prevalent posttranscriptional modification of RNA, mediated by the adenosine deaminases acting on RNA (ADAR) proteins. Mammalian transcriptomes contain tens of thousands to millions of A-to-I editing events.
Qinyi Zhang, Carl R. Walkley
openaire   +2 more sources

Adar, n.

2023
openaire   +1 more source

Impact of ADAR-induced editing of minor viral RNA populations on replication and transmission of SARS-CoV-2

Proceedings of the National Academy of Sciences of the United States of America, 2022
Johan Ringlander, Joshua Fingal, Hanna Kann   +2 more
exaly