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RNA editing in cardiovascular health and disease. [PDF]

Commun Biol
Huang X, Solomon C, McVey DG, Ye S.
europepmc   +1 more source

The post-pandemic pivot: mRNA therapeutics enter the chronic rare disease arena. [PDF]

Mol Ther Nucleic Acids
Giangrande PH.
europepmc   +1 more source

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RNA Editing by Mammalian ADARs

2011
The main type of RNA editing in mammals is the conversion of adenosine to inosine which is translated as if it were guanosine. The enzymes that catalyze this reaction are ADARs (adenosine deaminases that act on RNA), of which there are four in mammals, two of which are catalytically inactive. ADARs edit transcripts that encode proteins expressed mainly
Marion, Hogg, Simona, Paro, Liam P, Keegan, Mary A, O'Connell   +3 more
openaire   +2 more sources

ADAR and Immune Silencing in Cancer

Trends in Cancer, 2019
The regulation of immune responses by tumors is central to their survival. By diminishing the production of interferon (IFN) and other inflammatory mediators, tumors enhance immune evasion. Responses initiated by nucleic acid sensors and triggered by dysregulated RNA transcription and cytoplasmic DNA undergo down-modulation in tumors.
openaire   +2 more sources

Role of ADARs in Mouse Development

2011
RNA editing by deamination of adenosine to inosine (A-to-I editing) is a physiologically important posttranscriptional mechanism that can regulate expression of genes by modifying their transcripts. A-to-I editing is mediated by adenosine deaminases acting on RNA (ADAR) that can catalytically exchange adenosines to inosines, with varying efficiency ...
Carl R, Walkley, Brian, Liddicoat, Jochen C, Hartner   +2 more
openaire   +2 more sources

Purification and Assay of ADAR Activity

2007
ADAR editing enzymes are found in all multicellular animals and are conserved in sequence and protein organization. The number of ADAR genes differs between animals, ranging from three in mammals to one in Drosophila. ADAR is also alternatively spliced to generate isoforms that can differ significantly in enzymatic activity.
Liam P, Keegan, Joshua J, Rosenthal, Loretta M, Roberson, Mary A, O'Connell   +3 more
openaire   +2 more sources

Regulation and Functions of ADAR in Drosophila

2011
Drosophila melanogaster has a single Adar gene encoding a protein related to mammalian ADAR2 that edits transcripts encoding glutamate receptor subunits. We describe the structure of the Drosophila Adar locus and use ModENCODE information to supplement published data on Adar gene transcription, and splicing.
Simona, Paro, Xianghua, Li, Mary A, O'Connell, Liam P, Keegan   +3 more
openaire   +2 more sources