Results 11 to 20 of about 8,355 (219)

ADAR Family Proteins: A Structural Review

Current Issues in Molecular Biology
This review aims to highlight the structures of ADAR proteins that have been crucial in the discernment of their functions and are relevant to future therapeutic development.
Carolyn N. Ashley, Emmanuel Broni, Whelton A. Miller   +2 more
doaj   +3 more sources

What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs [PDF]

Open Biology, 2020
Adenosine-to-inosine (A-to-I) editing is a post-transcriptional modification of RNA which changes its sequence, coding potential and secondary structure.
Jacki E. Heraud-Farlow, Carl R. Walkley   +1 more
doaj   +1 more source

The role of dsRNA A-to-I editing catalyzed by ADAR family enzymes in the pathogeneses

RNA Biology
The process of adenosine deaminase (ADAR)-catalyzed double-stranded RNA (dsRNA) Adenosine-to-Inosine (A-to-I) editing is essential for the correction of pathogenic mutagenesis, as well as the regulation of gene expression and protein function in mammals.
Wanqing Liu, Yufan Wu, Tong Zhang, Xiaobo Sun, Dean Guo, Zizhao Yang   +5 more
doaj   +2 more sources

ADAR Therapeutics as a New Tool for Personalized Medicine. [PDF]

Genes (Basel)
Bertoli M, La Via L, Barbon A.
europepmc   +2 more sources

Heterochromatin: On the ADAR Radar? [PDF]

Current Biology, 2005
Vigilin proteins, the absence of which is known to cause abnormalities in heterochromatin, have been found to bind edited RNAs. Molecular complexes including vigilin comprise proteins involved with RNA editing and with DNA repair, making connections between these processes and RNA-based silencing mechanisms.
Weiwu Xie, Harsh H. Kavi, James A. Birchler, Harvey R. Fernandez   +3 more
openaire   +2 more sources

Identification of the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria [PDF]

Jichu yixue yu linchuang, 2023
Objective To analyze the clinical features and to identify the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria (DSH).
YANG Xueting, GUO Kexin, SUN Yang, WANG Rongrong, MA Donglai, ZHANG Xue
doaj   +1 more source

Programming ADAR-recruiting hairpin RNA sensor to detect endogenous molecules. [PDF]

Nucleic Acids Res
Qin PP, Chen PR, Tan L, Chu X, Ye BC, Yin BC.   +5 more
europepmc   +2 more sources

The ADAR protein family [PDF]

Genome Biology, 2012
Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional process by which adenosines are selectively converted to inosines in double-stranded RNA (dsRNA) substrates. A highly conserved group of enzymes, the adenosine deaminase acting on RNA (ADAR) family, mediates this reaction.
Yiannis A. Savva, Leila E. Rieder, Robert A. Reenan   +2 more
openaire   +3 more sources

Elevated ADAR expression is significantly linked to shorter overall survival and immune infiltration in patients with lung adenocarcinoma

Mathematical Biosciences and Engineering, 2023
To date, few studies have investigated whether the RNA-editing enzymes adenosine deaminases acting on RNA (ADARs) influence RNA functioning in lung adenocarcinoma (LUAD).
Siqi Hu , Fang Wang, Junjun Yang, Xingxiang Xu   +3 more
doaj   +1 more source

ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications [PDF]

Annals of Translational Medicine, 2019
Adenosine deaminases acting on RNA (ADARs) catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNA, which can change the codons after transcription. Abnormal ADAR editing is present in a variety of cancers. However, the study of the biological effects of ADARs in cancer is not very deep.
Wen Gao, Yue Zhang, Jing Xu, Huizhu Qian
openaire   +3 more sources