Results 11 to 20 of about 40,794 (233)

Tripartite motif 47 promotes the development of thyroid carcinoma through ADAR ubiquitination [PDF]

Molecular Medicine
Background Tripartite motif 47 (TRIM47) plays a vital role in the carcinogenesis and drug resistance of various cancers, whereas the function of TRIM47 in thyroid carcinoma (TC) remains unclear.
Hongzhou Liu, Xiaodong Hu, Tan Li, Yuhan Wang, Xiaomin Fu   +4 more
doaj   +3 more sources

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs [PDF]

Genome Biology, 2017
One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes.
Carl R. Walkley, Jin Billy Li
doaj   +7 more sources

Aicardi-Goutières syndrome type 6: report of ADAR variant and clinical outcome after ruxolitinib treatment in the neonatal period [PDF]

Pediatric Rheumatology Online Journal
Background Aicardi-Goutières Syndrome is a monogenic type 1 interferonopathy with infantile onset, characterized by a variable degree of neurological damage.
Alba Gabaldon-Albero, Carla Martin-Grau, Miguel Marti-Masanet , Alejandro Lopez-Jimenez, Roberto Llorens, Beatriz Beseler-Soto, Sergio Martin-Zamora, Berta Lopez, Inmaculada Calvo, Sara Hernandez-Muela, Monica Rosello, Carmen Orellana, Francisco Martinez   +12 more
doaj   +3 more sources

An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing [PDF]

Nature Communications
Custom RNA base editing exploiting the human Adenosine Deaminase Acting on RNA (ADAR) enzyme may enable therapeutic gene editing without DNA damage or use of foreign proteins.
Susan M. Byrne, Stephen M. Burleigh, Robert Fragoza, Yue Jiang, Yiannis Savva, Ricky Pabon, Evan Kania, Joseph Rainaldi, Andrew Portell, Prashant Mali, Adrian W. Briggs   +10 more
doaj   +3 more sources

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins [PDF]

Biomolecules, 2015
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Niamh Mannion, Fabiana Arieti, Angela Gallo, Liam P. Keegan, Mary A. O'Connell   +4 more
doaj   +4 more sources

Adar contributes to genome integrity by regulating R-loop homeostasis in Drosophila [PDF]

BMC Biology
Background Adenosine deaminase acting on RNA (Adar) is a critical enzyme involved in post-transcriptional epigenetic regulation through adenosine-to-inosine (A-to-I) RNA editing.
Xuedi Zhang, Hongyun Liu, Ju Peng, Guangbin Wang, Xiangyu Wu, Shuai Li, Jie Zheng, Qianwen Sun, Guanjun Gao   +8 more
doaj   +2 more sources

Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR. [PDF]

PLoS ONE
Therapeutic targeting of the adenosine deaminase ADAR has great potential in cancer and other indications; however, it remains unclear what approach can enable effective and selective therapeutic inhibition.
Benjamin G Gowen, Kory Melton, Weng In Leong, Prachi Khekare, Shannon McCawley, Jean Chan, Pierre Boivin, Vihasi Jani, Aaron J Cantor, Akshay Tambe, Mary Haak-Frendscho, Mary J Janatpour, Spencer C Wei   +12 more
doaj   +2 more sources

RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells [PDF]

Molecular Metabolism
Objective: A longstanding question in type 1 diabetes (T1D) research pertains to the selective loss of β-cells whilst neighboring islet α-cells remain unharmed.
Shani Peleg, Liza Zamashanski, Jonathan Belin, Roy Novoselsky, Roni Cohen-Fultheim, Udi Ehud Knebel, Benjamin Glaser, Shalev Itzkovitz, Klaus H. Kaestner, Alvin C. Powers, Erez Y. Levanon, Agnes Klochendler, Yuval Dor   +12 more
doaj   +2 more sources

ADAR Family Proteins: A Structural Review

Current Issues in Molecular Biology
This review aims to highlight the structures of ADAR proteins that have been crucial in the discernment of their functions and are relevant to future therapeutic development.
Carolyn N. Ashley, Emmanuel Broni, Whelton A. Miller   +2 more
doaj   +3 more sources

VIRMA promotes NSCLC progression by modifying ADAR m6A and increasing the activity of the TGF-β signaling pathway [PDF]

Scientific Reports
The N6-methyladenosine (m6A) modification is prevalently found in mRNAs and lncRNAs in various eukaryotic organisms, playing a crucial role in biological processes.
Yuchen Shan, Yongfei Fan, Xudong Zhu, Yi Zhao, Xiangseng Liu, Xiaoyu Duan, Zhaojia Gao, Ming Lou, Kai Yuan   +8 more
doaj   +2 more sources