Results 11 to 20 of about 42,601 (251)

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins [PDF]

Biomolecules, 2015
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Niamh Mannion, Fabiana Arieti, Angela Gallo, Liam P. Keegan, Mary A. O'Connell   +4 more
doaj   +4 more sources

Bilateral striatal necrosis caused by ADAR mutations in two siblings with dystonia and freckles-like skin changes that should be differentiated from Leigh syndrome [PDF]

Folia Neuropathologica, 2016
Pathogenic molecular variants in the ADAR gene are a known cause of rare diseases, autosomal recessive Aicardi- Goutières syndrome type 6, severe infantile encephalopathy with intracranial calcifications and dominant dyschromatosis symmetrica hereditaria,
Dorota Piekutowska-Abramczuk, Hanna Mierzewska, Monika Bekiesińska-Figatowska, Elżbieta Ciara, Joanna Trubicka, Maciej Pronicki, Dariusz Rokicki, Małgorzata Rydzanicz, Rafał Płoski, Ewa Pronicka   +9 more
doaj   +2 more sources

Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR. [PDF]

PLoS ONE
Therapeutic targeting of the adenosine deaminase ADAR has great potential in cancer and other indications; however, it remains unclear what approach can enable effective and selective therapeutic inhibition.
Benjamin G Gowen, Kory Melton, Weng In Leong, Prachi Khekare, Shannon McCawley, Jean Chan, Pierre Boivin, Vihasi Jani, Aaron J Cantor, Akshay Tambe, Mary Haak-Frendscho, Mary J Janatpour, Spencer C Wei   +12 more
doaj   +2 more sources

Evaluation of in vitro liver models and non-human primates for predicting ADAR RNA editing efficiency in human liver. [PDF]

Sci Rep
Aguila M, Cnubben NHP, Parfitt DA, Albuquerque B, de Visser PC, Molendijk M, Marques L, van Berkel M, Platenburg GJ.   +8 more
europepmc   +3 more sources

RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells [PDF]

Molecular Metabolism
Objective: A longstanding question in type 1 diabetes (T1D) research pertains to the selective loss of β-cells whilst neighboring islet α-cells remain unharmed.
Shani Peleg, Liza Zamashanski, Jonathan Belin, Roy Novoselsky, Roni Cohen-Fultheim, Udi Ehud Knebel, Benjamin Glaser, Shalev Itzkovitz, Klaus H. Kaestner, Alvin C. Powers, Erez Y. Levanon, Agnes Klochendler, Yuval Dor   +12 more
doaj   +2 more sources

Emerging clinical applications of ADAR based RNA editing. [PDF]

Stem Cells Transl Med
Rainaldi J, Mali P, Nourreddine S.
europepmc   +2 more sources

What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs [PDF]

Open Biology, 2020
Adenosine-to-inosine (A-to-I) editing is a post-transcriptional modification of RNA which changes its sequence, coding potential and secondary structure.
Jacki E. Heraud-Farlow, Carl R. Walkley   +1 more
doaj   +1 more source

ANALYSIS OF FAST NEUTRON TRANSPORT IN CHLORIDE SALTS USING MONTE CARLO METHOD

Acta Polytechnica CTU Proceedings, 2020
The aim of this paper is to present results of fast neutron behavior analysis within the chloride salts environment using simulations based on Monte Carlo method (MCNP 6.2).
Ondřej Šťastný, Karel Katovský, Dušan Král, Antonín Krása, Kamil Števanka   +4 more
doaj   +1 more source

Elevated ADAR expression is significantly linked to shorter overall survival and immune infiltration in patients with lung adenocarcinoma

Mathematical Biosciences and Engineering, 2023
To date, few studies have investigated whether the RNA-editing enzymes adenosine deaminases acting on RNA (ADARs) influence RNA functioning in lung adenocarcinoma (LUAD).
Siqi Hu , Fang Wang, Junjun Yang, Xingxiang Xu   +3 more
doaj   +1 more source

Identification of the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria [PDF]

Jichu yixue yu linchuang, 2023
Objective To analyze the clinical features and to identify the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria (DSH).
YANG Xueting, GUO Kexin, SUN Yang, WANG Rongrong, MA Donglai, ZHANG Xue
doaj   +1 more source