Results 21 to 30 of about 44,969 (289)

8-Azaadenosine and 8-Chloroadenosine are not Selective Inhibitors of ADAR [PDF]

Cancer Research Communications, 2021
The RNA editing enzyme ADAR, is an attractive therapeutic target for multiple cancers. Through its deaminase activity, ADAR edits adenosine to inosine in dsRNAs.
Kyle A. Cottrell, Luisangely Soto-Torres, Michael G. Dizon, Jason D. Weber   +3 more
semanticscholar   +5 more sources

ADAR Editing in Viruses: An Evolutionary Force to Reckon with [PDF]

Genome Biology and Evolution, 2021
Adenosine Deaminases that Act on RNA (ADARs) are RNA editing enzymes that play a dynamic and nuanced role in regulating transcriptome and proteome diversity.
H. Piontkivska, Benjamin Wales-McGrath, M. Miyamoto, M. Wayne   +3 more
semanticscholar   +3 more sources

Systematic analysis of A-to-I RNA editing upon release of ADAR from the nucleolus

RNA Biology
Adenosine-to-inosine (A-to-I) RNA editing, catalysed by two ADAR isoforms (p110 and p150) and ADARB1, is a critical regulatory step in gene expression.
Ruben Lattuca, Rümeyza Bascetin, Vincent Detours, Denis L.J. Lafontaine   +3 more
doaj   +2 more sources

Long non-coding RNA ATXN8OS promotes ferroptosis and inhibits the temozolomide-resistance of gliomas through the ADAR/GLS2 pathway

Brain Research Bulletin, 2022
As the most common malignant tumor, gliomas remain a poor prognosis while chemotherapy resistance is a medical problem for the treatment of glioma.
Jin Luo, Rui Bai, Yunxiao Liu, Hong Bi, Xiangzhen Shi, Chongxiao Qu   +5 more
doaj   +2 more sources

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability. [PDF]

Mol Oncol
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Skolariki A, Jady-Clark RL, Parkes EE.
europepmc   +2 more sources

What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs [PDF]

Open Biology, 2020
Adenosine-to-inosine (A-to-I) editing is a post-transcriptional modification of RNA which changes its sequence, coding potential and secondary structure.
Jacki E. Heraud-Farlow, Carl R. Walkley   +1 more
doaj   +1 more source

ADAR RNA Modifications, the Epitranscriptome and Innate Immunity. [PDF]

Trends in Biochemical Sciences, 2021
Modified bases act as marks on cellular RNAs so that they can be distinguished from foreign RNAs, reducing innate immune responses to endogenous RNA. In humans, mutations giving reduced levels of one base modification, adenosine-to-inosine deamination, cause a viral infection mimic syndrome, a congenital encephalitis with aberrant interferon induction.
J. Quin, Jiří Sedmík, Dragana Vukić, Anzer Khan, L. Keegan, M. O’Connell   +5 more
semanticscholar   +5 more sources

Programming ADAR-recruiting hairpin RNA sensor to detect endogenous molecules. [PDF]

Nucleic Acids Res
Qin PP, Chen PR, Tan L, Chu X, Ye BC, Yin BC.   +5 more
europepmc   +2 more sources

Heterochromatin: On the ADAR Radar? [PDF]

Current Biology, 2005
Vigilin proteins, the absence of which is known to cause abnormalities in heterochromatin, have been found to bind edited RNAs. Molecular complexes including vigilin comprise proteins involved with RNA editing and with DNA repair, making connections between these processes and RNA-based silencing mechanisms.
Weiwu Xie, Harsh H. Kavi, James A. Birchler, Harvey R. Fernandez   +3 more
openaire   +2 more sources

The ADAR protein family [PDF]

Genome Biology, 2012
Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional process by which adenosines are selectively converted to inosines in double-stranded RNA (dsRNA) substrates. A highly conserved group of enzymes, the adenosine deaminase acting on RNA (ADAR) family, mediates this reaction.
Yiannis A. Savva, Leila E. Rieder, Robert A. Reenan   +2 more
openaire   +3 more sources