Results 21 to 30 of about 42,221 (215)
Identification of the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria [PDF]
Jichu yixue yu linchuang, 2023 Objective To analyze the clinical features and to identify the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria (DSH).
YANG Xueting, GUO Kexin, SUN Yang, WANG Rongrong, MA Donglai, ZHANG Xue
doaj +1 more source
Genome Biology, 2012 Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional process by which adenosines are selectively converted to inosines in double-stranded RNA (dsRNA) substrates. A highly conserved group of enzymes, the adenosine deaminase acting on RNA (ADAR) family, mediates this reaction.
Savva, Yiannis A +2 more
openaire +2 more sources
ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications [PDF]
Annals of Translational Medicine, 2019 Adenosine deaminases acting on RNA (ADARs) catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNA, which can change the codons after transcription. Abnormal ADAR editing is present in a variety of cancers. However, the study of the biological effects of ADARs in cancer is not very deep.
Yue, Zhang +3 more
openaire +2 more sources
Heterochromatin: On the ADAR Radar? [PDF]
Current Biology, 2005 Vigilin proteins, the absence of which is known to cause abnormalities in heterochromatin, have been found to bind edited RNAs. Molecular complexes including vigilin comprise proteins involved with RNA editing and with DNA repair, making connections between these processes and RNA-based silencing mechanisms.
Fernandez, H.R. +3 more
openaire +2 more sources
ADARs have effects beyond RNA editing [PDF]
Cell Cycle, 2009 hairpin-mediated silencing and partially restores the red eye pigment. Inactive ADAR1p150 restored the pigmentation to 40% of ADAR1p150 levels suggesting that binding alone can influence processing of long duplexes into siRNAs. Cleavage by DICER is thought to be affected as this antagonism occurs in the cytoplasm and DICER can partially suppress the ...
Heale, Bret S E +2 more
openaire +3 more sources
Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome
Cell Reports, 2015 Little is known about how RNA editing operates in cancer. Transcriptome analysis of 68 normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly, on the same loci, across tissues.
Debora Fumagalli +18 more
doaj +1 more source
Measuring Tie Strength in Implicit Social Networks [PDF]
, 2011 Given a set of people and a set of events they attend, we address the problem of measuring connectedness or tie strength between each pair of persons given that attendance at mutual events gives an implicit social network between people.
Eliassi-Rad, Tina, Gupte, Mangesh
core +2 more sources
Prediction of scientific collaborations through multiplex interaction networks [PDF]
, 2020 Link prediction algorithms can help to understand the structure and dynamics of scientific collaborations and the evolution of Science. However, available algorithms based on similarity between nodes of collaboration networks are bounded by the limited ...
Aleta, Alberto +4 more
core +4 more sources
Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]
, 2016 Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
core +1 more source
Promoting RNA editing by ADAR attraction [PDF]
Genome Biology, 2017 Concentration is important and not only while driving; a new study indicates how an adjacent genomic element helps to increase the efficiency of a specific adenosine to inosine RNA editing reaction, by providing a means to increase the local concentration of the RNA editing enzyme ADAR.
Miri Danan-Gotthold, Erez Y. Levanon
openaire +3 more sources