Results 21 to 30 of about 40,794 (233)
Charting and probing the activity of ADARs in human development and cell-fate specification [PDF]
Nature CommunicationsAdenosine deaminases acting on RNA (ADARs) impact diverse cellular processes and pathological conditions, but their functions in early cell-fate specification remain less understood.
Amir Dailamy +10 more
doaj +2 more sources
Scientific ReportsThe APOBEC/AID family is known for its mutator activity, and recent evidence also supports the potential impact of ADARs. Furthermore, the mutator impacts of APOBEC/ADAR mutations have not yet been investigated.
Ahmadreza Niavarani
doaj +2 more sources
What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs [PDF]
Open Biology, 2020 Adenosine-to-inosine (A-to-I) editing is a post-transcriptional modification of RNA which changes its sequence, coding potential and secondary structure.
Jacki E. Heraud-Farlow +1 more
doaj +1 more source
Genome Biology, 2012 Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional process by which adenosines are selectively converted to inosines in double-stranded RNA (dsRNA) substrates. A highly conserved group of enzymes, the adenosine deaminase acting on RNA (ADAR) family, mediates this reaction.
Yiannis A. Savva +2 more
openaire +3 more sources
Heterochromatin: On the ADAR Radar? [PDF]
Current Biology, 2005 Vigilin proteins, the absence of which is known to cause abnormalities in heterochromatin, have been found to bind edited RNAs. Molecular complexes including vigilin comprise proteins involved with RNA editing and with DNA repair, making connections between these processes and RNA-based silencing mechanisms.
Weiwu Xie +3 more
openaire +2 more sources
ADARs: pleiotropy in function, versatility in application. [PDF]
Nucleic Acids ResAbstract RNA processing is essential for proper cellular function, contributing to protein and cell state diversity, and is often dysregulated in diseased states. A key subset of RNA regulators is the double-stranded RNA-specific adenosine deaminase (ADAR) protein family, which hydrolytically deaminates double-stranded RNA, causing an ...
Zhang Y, Bryant J, Herron L, Mali P.
europepmc +2 more sources
ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications [PDF]
Annals of Translational Medicine, 2019 Adenosine deaminases acting on RNA (ADARs) catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNA, which can change the codons after transcription. Abnormal ADAR editing is present in a variety of cancers. However, the study of the biological effects of ADARs in cancer is not very deep.
Wen Gao, Yue Zhang, Jing Xu, Huizhu Qian
openaire +3 more sources
Promoting RNA editing by ADAR attraction [PDF]
Genome Biology, 2017 Concentration is important and not only while driving; a new study indicates how an adjacent genomic element helps to increase the efficiency of a specific adenosine to inosine RNA editing reaction, by providing a means to increase the local concentration of the RNA editing enzyme ADAR.
Miri Danan-Gotthold, Erez Y. Levanon
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ADAR RNA Modifications, the Epitranscriptome and Innate Immunity [PDF]
Trends in Biochemical Sciences, 2021 Modified bases act as marks on cellular RNAs so that they can be distinguished from foreign RNAs, reducing innate immune responses to endogenous RNA. In humans, mutations giving reduced levels of one base modification, adenosine-to-inosine deamination, cause a viral infection mimic syndrome, a congenital encephalitis with aberrant interferon induction.
Quin, Jaclyn +5 more
openaire +4 more sources
Evaluation of the Interplay between the ADAR Editome and Immunotherapy in Melanoma [PDF]
Non-Coding RNA, 2021 Background: RNA editing is a highly conserved posttranscriptional mechanism that contributes to transcriptome diversity. In mammals, it includes nucleobase deaminations that convert cytidine (C) into uridine (U) and adenosine (A) into inosine (I).
Steve Pascolo +11 more
openaire +6 more sources