Results 21 to 30 of about 42,601 (251)
Genome Biology, 2012 Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional process by which adenosines are selectively converted to inosines in double-stranded RNA (dsRNA) substrates. A highly conserved group of enzymes, the adenosine deaminase acting on RNA (ADAR) family, mediates this reaction.
Savva, Yiannis A +2 more
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ADAR expression and copy number variation in patients with advanced gastric cancer
BMC Gastroenterology, 2020 Background Gastric cancer (GC) is a world health problem and it is the third leading cause of cancer deaths worldwide. The current practice for prognosis assessment in GC is based on radiological and pathological criteria and they may not result in an ...
Javad Behroozi +3 more
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ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications [PDF]
Annals of Translational Medicine, 2019 Adenosine deaminases acting on RNA (ADARs) catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNA, which can change the codons after transcription. Abnormal ADAR editing is present in a variety of cancers. However, the study of the biological effects of ADARs in cancer is not very deep.
Yue, Zhang +3 more
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The A to I editing landscape in melanoma and its relation to clinical outcome
RNA Biology, 2022 RNA editing refers to non-transient RNA modifications that occur after transcription and prior to translation by the ribosomes. RNA editing is more widespread in cancer cells than in non-transformed cells and is associated with tumorigenesis of various ...
Austeja Amweg +11 more
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Dynamic hyper-editing underlies temperature adaptation in Drosophila. [PDF]
PLoS Genetics, 2017 In Drosophila, A-to-I editing is prevalent in the brain, and mutations in the editing enzyme ADAR correlate with specific behavioral defects. Here we demonstrate a role for ADAR in behavioral temperature adaptation in Drosophila.
Ilana Buchumenski +6 more
doaj +1 more source
Prediction of scientific collaborations through multiplex interaction networks [PDF]
, 2020 Link prediction algorithms can help to understand the structure and dynamics of scientific collaborations and the evolution of Science. However, available algorithms based on similarity between nodes of collaboration networks are bounded by the limited ...
Aleta, Alberto +4 more
core +4 more sources
Heterochromatin: On the ADAR Radar? [PDF]
Current Biology, 2005 Vigilin proteins, the absence of which is known to cause abnormalities in heterochromatin, have been found to bind edited RNAs. Molecular complexes including vigilin comprise proteins involved with RNA editing and with DNA repair, making connections between these processes and RNA-based silencing mechanisms.
Fernandez, H.R. +3 more
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2023 RNA editing holds great promise for the therapeutic correction of pathogenic, single nucleotide variants (SNV) in the human transcriptome since it does not risk creating permanent off-targets edits in the genome and has the potential for innovative ...
Julia-Sophia Bellingrath +5 more
doaj +1 more source
The Advantage of Evidential Attributes in Social Networks [PDF]
, 2017 Nowadays, there are many approaches designed for the task of detecting communities in social networks. Among them, some methods only consider the topological graph structure, while others take use of both the graph structure and the node attributes.
adar +7 more
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BMC Biology, 2020 Background In fly brains, the Drosophila Adar (adenosine deaminase acting on RNA) enzyme edits hundreds of transcripts to generate edited isoforms of encoded proteins.
Anzer Khan +8 more
doaj +1 more source