Results 51 to 60 of about 40,794 (233)
ADARs have effects beyond RNA editing [PDF]
Cell Cycle, 2009 hairpin-mediated silencing and partially restores the red eye pigment. Inactive ADAR1p150 restored the pigmentation to 40% of ADAR1p150 levels suggesting that binding alone can influence processing of long duplexes into siRNAs. Cleavage by DICER is thought to be affected as this antagonism occurs in the cytoplasm and DICER can partially suppress the ...
Heale, Bret S E +2 more
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Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections
BMC Genomics, 2023 Background RNA editing is a process that increases transcriptome diversity, often through Adenosine Deaminases Acting on RNA (ADARs) that catalyze the deamination of adenosine to inosine.
Benjamin Wales-McGrath +2 more
doaj +1 more source
T time for
EMBO reports, 2018 ADAR1, an RNA‐editing enzyme, plays a key role in preventing self‐RNAs from triggering autoinflammatory responses. In this issue of EMBO reports , Nakahama and colleagues uncover a novel role for ADAR1 in T cells [1]. The authors report that in T cells, ADAR1‐mediated suppression of type I interferon‐stimulated gene (ISG) expression is required for ...
Hachung Chung, Charles M. Rice
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Global Transcriptome Analysis of RNA Abundance Regulation by ADAR in Lung Adenocarcinoma
EBioMedicine, 2018 Despite tremendous advances in targeted therapies against lung adenocarcinoma, the majority of patients do not benefit from personalized treatments. A deeper understanding of potential therapeutic targets is crucial to increase the survival of patients ...
Michael F. Sharpnack +7 more
doaj +1 more source
Matching commercial thrips predating phytoseids with the highly diversified climatic conditions of different strawberry production systems [PDF]
, 2017 Flower inhabiting thrips (Order: Thysanoptera) are a major threat to fruit quality in strawberry production around the world. As chemical control is often inefficient, alternative control measures are of broad and current interest.
Beliën, T +10 more
core +2 more sources
ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression
Cell Reports, 2013 Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells.
Isabel X. Wang +5 more
doaj +1 more source
Stochastic Block Models with Multiple Continuous Attributes [PDF]
, 2018 The stochastic block model (SBM) is a probabilistic model for community structure in networks. Typically, only the adjacency matrix is used to perform SBM parameter inference.
Bonacci, Thomas +4 more
core +3 more sources
Inferring Person-to-person Proximity Using WiFi Signals [PDF]
, 2016 Today's societies are enveloped in an ever-growing telecommunication infrastructure. This infrastructure offers important opportunities for sensing and recording a multitude of human behaviors.
Lehmann, Sune +4 more
core +2 more sources
ADARs: Viruses and Innate Immunity [PDF]
, 2011 Double-stranded RNA (dsRNA) functions both as a substrate of ADARs and also as a molecular trigger of innate immune responses. ADARs, adenosine deaminases that act on RNA, catalyze the deamination of adenosine (A) to produce inosine (I) in dsRNA. ADARs thereby can destablize RNA structures, because the generated I:U mismatch pairs are less stable than ...
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Mechanistic insights into editing-site specificity of ADARs [PDF]
Proceedings of the National Academy of Sciences, 2012 Adenosine deaminases that act on RNA (ADARs) deaminate adenosines in dsRNA to produce inosines. ADARs are essential in mammals and are particularly important in the nervous system. Altered levels of adenosine-to-inosine (A-to-I) editing are observed in several diseases. The extent to which an adenosine is edited depends on sequence context. Human ADAR2
Ashani Kuttan, Brenda L. Bass
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