Results 51 to 60 of about 43,703 (264)
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Viral RNA may be edited by enzymes of the ADAR family that deaminate adenosine residues with ensuing A→G mutations. We found multiple A→G mutations in minor viral populations of the SARS-CoV-2 genome.
Johan Ringlander +10 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance APOL1-associated kidney disease occurs in some but not all individuals carrying two copies of APOL1 genetic risk variants. The factors leading to kidney disease are incompletely understood. Viral illnesses or other environmental triggers are
Cristian V Riella +13 more
semanticscholar +1 more source
ADAR RNA editing below the backbone [PDF]
RNA, 2017 ADAR RNA editing enzymes (adenosine deaminases acting on RNA) that convert adenosine bases to inosines were first identified biochemically 30 years ago. Since then, studies on ADARs in genetic model organisms, and evolutionary comparisons between them, continue to reveal a surprising range of pleiotropic biological effects of ADARs. This review focuses
Liam Keegan +3 more
openaire +2 more sources
Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]
, 2016 Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
core +1 more source
Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome
Cell Reports, 2015 Little is known about how RNA editing operates in cancer. Transcriptome analysis of 68 normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly, on the same loci, across tissues.
Debora Fumagalli +18 more
doaj +1 more source
A-to-I-Edited miR-1304-3p Inhibits Glycolysis and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inactivating Wnt5a/ROR2 Signaling. [PDF]
Mol CarcinogABSTRACT A‐to‐I RNA editing is a pervasive mechanism in the human genome that affects the regulation of gene expression and is closely associated with the pathogenesis of numerous diseases. This study elucidates the regulatory mechanism of A‐to‐I edited miR‐1304‐3p in esophageal squamous cell carcinoma (ESCC). Western blot, immunohistochemistry, and RT‐
Chen P +8 more
europepmc +2 more sources
The Advantage of Evidential Attributes in Social Networks [PDF]
, 2017 Nowadays, there are many approaches designed for the task of detecting communities in social networks. Among them, some methods only consider the topological graph structure, while others take use of both the graph structure and the node attributes.
adar +7 more
core +3 more sources
Viruses, 2023 The Adenosine Deaminases Acting on RNA (ADAR) catalyze the posttranscriptional deamination of adenosine residues to inosine in double-stranded RNAs (dsRNAs, A-to-I editing), preventing the overactivation of dsRNA sensor molecules and interferons.
Vlatka Ivanišević +5 more
doaj +1 more source
Adenovirus VAI RNA Antagonizes the RNA-Editing Activity of the ADAR Adenosine Deaminase [PDF]
, 1998 The virus-associated VAI RNA of adenovirus is a small highly structured RNA that is required for the efficient translation of cellular and viral mRNAs at late times after infection.
Lei, Ming, Liu, Yong, Samuel, Charles E.
core +1 more source
ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site
Nucleic Acids Research, 2022 ADARs (adenosine deaminases acting on RNA) can be directed to sites in the transcriptome by complementary guide strands allowing for the correction of disease-causing mutations at the RNA level.
Erin E. Doherty +7 more
semanticscholar +1 more source