Results 1 to 10 of about 8,903 (187)

ADAR1 Regulates the ERK/c-FOS/MMP-9 Pathway to Drive the Proliferation and 
Migration of Non-small Cell Lung Cancer Cells [PDF]

Chinese Journal of Lung Cancer
Background and objective Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) binds to double-stranded RNA and catalyzes the deamination of adenosine (A) to inosine (I).
Li ZHANG, Xue PAN, Wenqing YAN, Shuilian ZHANG, Chiyu MA, Chenpeng LI, Kexin ZHU, Nijia LI, Zizhong YOU, Xueying ZHONG, Zhi XIE, Zhiyi LV, Weibang GUO, Yu CHEN, Danxia LU, Xuchao ZHANG   +15 more
doaj   +2 more sources

Loss of Adenosine Deaminase Acting on RNA 1 Induces Panoptosis and Immune Response in Ulcerative Colitis Gut Mucosa [PDF]

MedComm
The gut virome is a complex community that exists in equilibrium with the host. Disruptions of this balance could drive the development of inflammatory diseases, such as inflammatory bowel disease (IBD). RNA editing, particularly A‐to‐I editing by ADAR1,
Andrea Iannucci, Marco Colella, Macarena Quiroga, Rachele Frascatani, Lorenzo Tomassini, Claudia Maresca, Eleonora Franzè, Federica Laudisi, Giuseppe Sica, Irene Marafini, Alessandro Michienzi, Ivan Zanoni, Giovanni Monteleone, Ivan Monteleone   +13 more
doaj   +2 more sources

ADAR1 as a prognostic marker for patients with colorectal cancer and synchronous liver metastasis and a predictor of chemotherapy efficacy [PDF]

Scientific Reports
RNA editing by adenosine deaminase acting on RNA (ADAR) enzymes plays a role in cancer progression. However, its clinical significance in metastatic colorectal cancer (CRC) remains unclear.
Kaori Nitta, Kunitoshi Shigeyasu, Yoshitaka Kondo, Hibiki Umeda, Toshiaki Takahashi, Kazuya Moriwake, Kazuhiro Yoshida, Sho Takeda, Yuki Matsumi, Hiroyuki Kishimoto, Tomokazu Fuji, Kazuya Yasui, Kosei Takagi, Masashi Kayano, Shunsuke Nakamura, Hiroyuki Michiue, Hideki Yamamoto, Nobuhiko Kanaya, Yuhei Kondo, Eiki Miyake, Yusuke Yoshida, Ryohei Shoji, Yoshihiko Kakiuchi, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara   +25 more
doaj   +2 more sources

Propofol addiction drives neuronal senescence and cognitive decline via autophagy-mediated ADAR1/SIRT1 disruption. [PDF]

Commun Biol
Wang X, Lin S, Zou Z, Zhu D, Zhou J, Zhang X, Lv J, Zhou W, Liu Y, Si Z.   +9 more
europepmc   +2 more sources

In Silico Characterization of ADAR1: Structure, Dynamics, and Functional Implications. [PDF]

Curr Issues Mol Biol
Ashley CN, Broni E, Wood CM, Miller WA.
europepmc   +3 more sources

High-speed atomic force microscopy and 3D modeling reveal the structural dynamics of ADAR1 complexes [PDF]

Nature Communications
Targeting abnormal dysregulation of adenosine-to-inosine deamination by ADAR enzymes offers a promising therapeutic strategy in cancer research. However, the development of effective inhibitors is impeded by the incomplete structural information on ADAR1
Madhu Biyani, Yasuhiro Isogai, Kirti Sharma, Shoei Maeda, Hinako Akashi, Yui Sugai, Masataka Nakano, Noriyuki Kodera, Manish Biyani, Miki Nakajima   +9 more
doaj   +2 more sources

ADAR1 expression is associated with cervical cancer progression and negatively regulates NK cell activity [PDF]

JCI Insight
ADAR1 edits double-stranded RNAs (dsRNAs) by deaminating adenosines into inosines, preventing aberrant activation of innate immunity by endogenous dsRNAs, which may resemble viral structures.
Valentina Tassinari, Marta Kaciulis, Stefano Petrai, Helena Stabile, Angelina Pernazza, Martina Leopizzi, Valeria Di Maio, Francesca Belleudi, Danilo Ranieri, Vanessa Mancini, Innocenza Palaia, Federica Tanzi, Ludovica Lospinoso Severini, Silvia Ruggeri, Maria Emanuela Greco, Giovanni Bernardini, Alessandra Zingoni, Marco Cippitelli, Cristina Cerboni, Alessandra Soriani   +19 more
doaj   +2 more sources

ZYS-1 is not an ADAR1 inhibitor. [PDF]

RNA
Smoak CN, Gardner EN, Chua RN, Cottrell KA.   +3 more
europepmc   +3 more sources

ADAR1-Mediated RNA Editing Regulates Innate Immunity in Pulmonary Hypertension. [PDF]

Circ Res
Shen Y, Bisserier M.
europepmc   +3 more sources

ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17

Acta Pharmaceutica Sinica B, 2023
Pulmonary hypertension (PH) is an extremely malignant pulmonary vascular disease of unknown etiology. ADAR1 is an RNA editing enzyme that converts adenosine in RNA to inosine, thereby affecting RNA expression. However, the role of ADAR1 in PH development
Junting Zhang, Yiying Li, Jianchao Zhang, Lu Liu, Yuan Chen, Xusheng Yang, Xueyi Liao, Muhua He, Zihui Jia, Jun Fan, Jin-Song Bian, Xiaowei Nie   +11 more
doaj   +1 more source