Results 1 to 10 of about 7,998 (203)

ADAR1: a central regulator of dsRNA sensing in host-virus interactions [PDF]

Frontiers in Immunology
Adenosine deaminase acting on RNA 1 (ADAR1) is a key regulator of RNA homeostasis and innate immunity through its adenosine-to-inosine (A-to-I) editing of double-stranded RNAs (dsRNAs).
Congnuan Liu, Younho Choi
doaj   +2 more sources

Structural and mechanistic basis of ADAR1-mediated RNA editing and immune regulation [PDF]

Cell Insight
Adenosine deaminase acting on RNA 1 (ADAR1) is a central regulator of innate immunity. By binding to and catalyzing adenosine-to-inosine deamination within double-stranded RNAs, ADAR1 mitigates the immunogenicity of self-derived RNAs and preserves ...
Xiangyu Deng, Mariam Elsharkawy, Yang Gao   +2 more
doaj   +2 more sources

ADAR1 Regulates the ERK/c-FOS/MMP-9 Pathway to Drive the Proliferation and 
Migration of Non-small Cell Lung Cancer Cells [PDF]

Chinese Journal of Lung Cancer
Background and objective Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) binds to double-stranded RNA and catalyzes the deamination of adenosine (A) to inosine (I).
Li ZHANG, Xue PAN, Wenqing YAN, Shuilian ZHANG, Chiyu MA, Chenpeng LI, Kexin ZHU, Nijia LI, Zizhong YOU, Xueying ZHONG, Zhi XIE, Zhiyi LV, Weibang GUO, Yu CHEN, Danxia LU, Xuchao ZHANG   +15 more
doaj   +2 more sources

ADAR1 as a prognostic marker for patients with colorectal cancer and synchronous liver metastasis and a predictor of chemotherapy efficacy [PDF]

Scientific Reports
RNA editing by adenosine deaminase acting on RNA (ADAR) enzymes plays a role in cancer progression. However, its clinical significance in metastatic colorectal cancer (CRC) remains unclear.
Kaori Nitta, Kunitoshi Shigeyasu, Yoshitaka Kondo, Hibiki Umeda, Toshiaki Takahashi, Kazuya Moriwake, Kazuhiro Yoshida, Sho Takeda, Yuki Matsumi, Hiroyuki Kishimoto, Tomokazu Fuji, Kazuya Yasui, Kosei Takagi, Masashi Kayano, Shunsuke Nakamura, Hiroyuki Michiue, Hideki Yamamoto, Nobuhiko Kanaya, Yuhei Kondo, Eiki Miyake, Yusuke Yoshida, Ryohei Shoji, Yoshihiko Kakiuchi, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara   +25 more
doaj   +2 more sources

ADAR1 expression is associated with cervical cancer progression and negatively regulates NK cell activity [PDF]

JCI Insight
ADAR1 edits double-stranded RNAs (dsRNAs) by deaminating adenosines into inosines, preventing aberrant activation of innate immunity by endogenous dsRNAs, which may resemble viral structures.
Valentina Tassinari, Marta Kaciulis, Stefano Petrai, Helena Stabile, Angelina Pernazza, Martina Leopizzi, Valeria Di Maio, Francesca Belleudi, Danilo Ranieri, Vanessa Mancini, Innocenza Palaia, Federica Tanzi, Ludovica Lospinoso Severini, Silvia Ruggeri, Maria Emanuela Greco, Giovanni Bernardini, Alessandra Zingoni, Marco Cippitelli, Cristina Cerboni, Alessandra Soriani   +19 more
doaj   +2 more sources

ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17

Acta Pharmaceutica Sinica B, 2023
Pulmonary hypertension (PH) is an extremely malignant pulmonary vascular disease of unknown etiology. ADAR1 is an RNA editing enzyme that converts adenosine in RNA to inosine, thereby affecting RNA expression. However, the role of ADAR1 in PH development
Junting Zhang, Yiying Li, Jianchao Zhang, Lu Liu, Yuan Chen, Xusheng Yang, Xueyi Liao, Muhua He, Zihui Jia, Jun Fan, Jin-Song Bian, Xiaowei Nie   +11 more
doaj   +1 more source

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

Frontiers in Endocrinology, 2022
IntroductionEnterovirus infection has long been suspected as a possible trigger for type 1 diabetes. Upon infection, viral double-stranded RNA (dsRNA) is recognized by membrane and cytosolic sensors that orchestrate type I interferon signaling and the ...
Florian Szymczak, Roni Cohen-Fultheim, Sofia Thomaidou, Alexandra Coomans de Brachène, Angela Castela, Maikel Colli, Piero Marchetti, Erez Levanon, Decio Eizirik, Arnaud Zaldumbide   +9 more
doaj   +1 more source

RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.

PLoS Genetics, 2021
Adenosine deaminase acting on RNA 1 (ADAR1), an enzyme responsible for adenosine-to-inosine RNA editing, is composed of two isoforms: nuclear p110 and cytoplasmic p150.
Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara   +11 more
doaj   +1 more source

Expression and clinical significance of adenosine deaminase acting on RNA-1 in lung adenocarcinoma

Di-san junyi daxue xuebao, 2021
Objective To investigate the expression of adenosine deaminase acting on RNA-1 (ADAR1) in lung adenocarcinoma and its association with clinicopathological characteristics and prognosis.
YANG Wendi, YU Qian, GUO Zhengjun, PENG Yuan, YANG Zhenzhou   +4 more
doaj   +1 more source

ADAR1 has an oncogenic function and can be a prognostic factor in cervical cancer

Scientific Reports, 2023
Adenosine deaminase acting on RNA 1 (ADAR1), a recently described epigenetic modifier, is believed to play a critical oncogenic role in human cancers. However, its functional role and clinical significance in cervical cancer (CC) remain unclear.
Keiichiro Nakamura, Kunitoshi Shigeyasu, Kazuhiro Okamoto, Hirofumi Matsuoka, Hisashi Masuyama   +4 more
doaj   +1 more source