Results 91 to 100 of about 8,922 (205)

ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer

Tumor Biology, 2017
Tumours with a high mutation burden exhibit considerable neoantigens and tumour-infiltrating lymphocytes. RNA editing by ADAR1 is a source of changes in epitope.
In Hye Song, Young-Ae Kim, Sun-Hee Heo, In Ah Park, Miseon Lee, Won Seon Bang, Hye Seon Park, Gyungyub Gong, Hee Jin Lee   +8 more
doaj   +1 more source

Base extrusion is found at helical junctions between right- and left-handed forms of DNA and RNA [PDF]

, 2009
Base extrusion is a major structural feature at the junction between B- and Z-DNA (the B–Z junction) where a base pair is broken, and the two bases are extruded from the double helix. Despite the demonstration of base extrusion at the B–Z junction, it is
Kim, Dong Young, Kim, Doyoun, Kim, Kyeong Kyu, Kim, Yang-Gyun, Lee, Sangho, Reddy, Sanjith, Rich, Alexander   +6 more
core   +2 more sources

Effect of interferons on expression of adenosine deaminase acting on RNA 1 and hepatitis B virus replication in human hepatocellular carcinoma cells in vitro

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of type Ⅰ interferons (IFN-α and IFN-β) and type Ⅱ interferon (IFN-γ) on the expression of adenosine deaminase acting on RNA 1 (ADAR1, P110 and P150) and hepatitis B virus (HBV) replication in hepatocellular carcinoma (
LI Yimin, LI Yimin, YUAN Lin, YUAN Lin, YANG Shengyong   +4 more
doaj   +1 more source

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling [PDF]

, 2013
The Hedgehog (HH) signaling pathway has important roles in tumorigenesis and in embryonal patterning. The Gliomaassociated oncogene 1 (GLI1) is a key molecule in HH signaling, acting as a transcriptional effector and, moreover, is considered to be a ...
Mohammed Ferdous-Ur, Rahman, Palaniswamy, R., Pivarcsi, A., Shimokawa, T., Sonkoly, E., Ståhle, M., Tostar, U., Zaphiropoulos, P. G.   +7 more
core   +1 more source

Sono‐Controllable Janus Hydrogel Platform for Sequential Tumor Eradication and Bone Regeneration in Metastatic Breast Cancer

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Sequential tumor eradication and bone regeneration remain a significant challenge for patients with breast cancer bone metastases. This study develops a novel Janus hydrogel platform, which can achieve tumor elimination and bone repair under the action of different ultrasound frequencies.
Yitong Li, Yunyun Liu, Chuyun Lou, Xuejun Chen, Ying Zhang, Hui Shi, Jiayi Qiu, Shen Zhang, Taixia Wang, Xiaowei Wang, Haohao Yin, Huixiong Xu, Yifeng Zhang   +12 more
wiley   +1 more source

The majority of A-to-I RNA editing is not required for mammalian homeostasis

Genome Biology, 2019
Background Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sites across mammalian transcriptomes.
Alistair M. Chalk, Scott Taylor, Jacki E. Heraud-Farlow, Carl R. Walkley   +3 more
doaj   +1 more source

An RNA editing fingerprint of cancer stem cell reprogramming [PDF]

, 2015
BackgroundDeregulation of RNA editing by adenosine deaminases acting on dsRNA (ADARs) has been implicated in the progression of diverse human cancers including hematopoietic malignancies such as chronic myeloid leukemia (CML).
Angela C Court, Catriona Jamieson, Christian L Barrett, Elisa Lazzari, Kelly A Frazer, Leslie A Crews, Maria A Zipeto, Qingfei Jiang, Shawn Ali   +8 more
core   +1 more source

Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing

Cell Reports
Summary: Leukemia-initiating cells (LICs) are regarded as the origin of leukemia relapse and therapeutic resistance. Identifying direct stemness determinants that fuel LIC self-renewal is critical for developing targeted approaches.
Maria Rivera, Haoran Zhang, Jessica Pham, Jane Isquith, Qingchen Jenny Zhou, Larisa Balaian, Roman Sasik, Sabina Enlund, Adam Mark, Wenxue Ma, Frida Holm, Kathleen M. Fisch, Dennis John Kuo, Catriona Jamieson, Qingfei Jiang   +14 more
doaj   +1 more source

Overexpression of Egr1 Transcription Regulator Contributes to Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1 Knockout Mice

Cells
Adenosine deaminase acting on RNA 1 (ADAR1) is the principal enzyme for the adenosine-to-inosine RNA editing that prevents the aberrant activation of cytosolic nucleic acid sensors by endogenous double stranded RNAs and the activation of interferon ...
Lisa Zerad, Nadjet Gacem, Fanny Gayda, Lucie Day, Ketty Sinigaglia, Laurence Richard, Melanie Parisot, Nicolas Cagnard, Stephane Mathis, Christine Bole-Feysot, Mary A. O’Connell, Veronique Pingault, Emilie Dambroise, Liam P. Keegan, Jean Michel Vallat, Nadege Bondurand   +15 more
doaj   +1 more source

Lamarck and immunity: Somatic and germline evolution of antibody genes [PDF]

, 2009
Current work on the mechanism of hypermutation of somatically rearranged antibody variable (V) genes shows that the most likely mechanism involves both direct DNA modification (deamination of cytosines to uracils by AID deaminase) and strand nicking plus
Steele, E.J.
core   +1 more source