Results 91 to 100 of about 7,998 (203)

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown [PDF]

Cell, 2018
Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA), is incompletely understood. Mutations in ADAR1, an adenosine-to-inosine editing enzyme of dsRNA, cause Aicardi-Goutières syndrome, an autoinflammatory disorder associated
Hachung, Chung, Jorg J A, Calis, Xianfang, Wu, Tony, Sun, Yingpu, Yu, Stephanie L, Sarbanes, Viet Loan, Dao Thi, Abigail R, Shilvock, H-Heinrich, Hoffmann, Brad R, Rosenberg, Charles M, Rice   +10 more
openaire   +2 more sources

RNA editing enzyme ADAR1 is required for early T cell development

Blood Science, 2020
. The RNA editing enzyme ADAR1 has been shown to be an essential molecule for hematopoietic cell differentiation, embryonic development, and regulation of immune responses.
Richard Xufeng, Daibang Nie, Qiong Yang, Wang Wang, Tao Cheng, Qingde Wang   +5 more
doaj   +1 more source

An RNA editing fingerprint of cancer stem cell reprogramming [PDF]

, 2015
BackgroundDeregulation of RNA editing by adenosine deaminases acting on dsRNA (ADARs) has been implicated in the progression of diverse human cancers including hematopoietic malignancies such as chronic myeloid leukemia (CML).
Angela C Court, Catriona Jamieson, Christian L Barrett, Elisa Lazzari, Kelly A Frazer, Leslie A Crews, Maria A Zipeto, Qingfei Jiang, Shawn Ali   +8 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 2, Page 409-427, February 2026.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Endonuclease V: From Transcriptome Regulator to Chemical Biology Tool

ChemistryEurope, Volume 4, Issue 2, February 2026.
Post‐transcriptional modifications play a pivotal role in regulating the health and physiology of human cells, and adenosine‐to‐inosine (A‐to‐I) editing is one of the most abundant of these modifications. Inosine is read as guanosine by the cellular machinery, and this change impacts both the regulation and genetic code of RNA, in turn effectively ...
Prasanth Thota, Tyson D. Todd, Devanshi Purohit, Weina Cheng, Aastha, Jennifer M. Heemstra   +5 more
wiley   +1 more source

Antagonistic and stimulative roles of ADAR1 in RNA silencing [PDF]

RNA Biology, 2013
Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs (dsRNA). This A-to-I RNA editing pathway and the RNA interference (RNAi) pathway seem to interact antagonistically by competing for their common dsRNA substrates. For instance, A-to-I editing of certain
Kazuko, Nishikura, Masayuki, Sakurai, Kantaro, Ariyoshi, Hiromitsu, Ota   +3 more
openaire   +2 more sources

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling [PDF]

, 2013
The Hedgehog (HH) signaling pathway has important roles in tumorigenesis and in embryonal patterning. The Gliomaassociated oncogene 1 (GLI1) is a key molecule in HH signaling, acting as a transcriptional effector and, moreover, is considered to be a ...
Mohammed Ferdous-Ur, Rahman, Palaniswamy, R., Pivarcsi, A., Shimokawa, T., Sonkoly, E., Ståhle, M., Tostar, U., Zaphiropoulos, P. G.   +7 more
core   +1 more source

Gut metabolites identified in cerebrospinal fluid of genetic interferonopathy support gut–brain endothelial dysfunction

Clinical &Translational Immunology, Volume 15, Issue 2, 2026.
Abstract Objective Aicardi–Goutières syndrome (AGS) is a rare genetic interferonopathy because of aberrant DNA or RNA metabolism with secondary host anti‐viral (interferon) activation. This metabolomics study aimed to improve the biological understanding of AGS and explore potential biomarkers.
Russell C Dale, Madysen Elbourne, Markus J Hofer, Shrujna Patel, Shekeeb Mohammad, Velda X Han, Josephine Yu, Shanlin Fu, Arlene D'Silva, Michelle A Farrar, Sushil Bandodkar, Jingya J Yan   +11 more
wiley   +1 more source

Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms [PDF]

, 2011
Understanding the genesis of the block haplotype structure of the genome is a major challenge. With the completion of the sequencing of the Human Genome and the initiation of the HapMap project the concept that the chromosomes of the mammalian genome are
Carnegie, P., Dawkins, R.L., Lester, S., Lindley, R.A., Millman, J.A., Pain, G.N., Steele, E.J., Stewart, B.J., Williamson, J.F.   +8 more
core   +2 more sources