Results 121 to 130 of about 8,922 (205)

ADAR1, a promising “protecting” biomarker in oral squamous cell carcinoma [PDF]

, 2019
Campisi, Giuseppina, CAPONIO, VITO CARLO ALBERTO, Dioguardi, Mario, Lo Muzio, Lorenzo, Mascitti, Marco, Santarelli, Andrea   +5 more
core   +1 more source

Characterization of the molecular dysfunctions occurring in Aicardi-Goutières syndrome patients with mutations in ADAR1

, 2023
Sofian Al Wardat, Loredana Frassinelli, Elisa Orecchini, Federica Rey, Silvia Anna Ciafrè, Silvia Galardi, Jessica Garau, Stella Gagliardi, Simona Orcesi, Davide Tonduti, Stephana Carelli, Cristina Cereda, Ernesto Picardi, Alessandro Michienzi   +13 more
openalex   +1 more source

ADAR1 has an oncogenic function and can be a prognostic factor in cervical cancer [PDF]

, 2022
Keiichiro Nakamura, Kunitoshi Shigeyasu, Kazuhiro Okamoto, Hirofumi Matsuoka, Hisashi Masuyama   +4 more
openalex   +1 more source

Dimerization of ADAR1 modulates site-specificity of RNA editing

Nature Communications
Adenosine-to-inosine editing is catalyzed by adenosine deaminases acting on RNA (ADARs) in double-stranded RNA (dsRNA) regions. Although three ADARs exist in mammals, ADAR1 is responsible for the vast majority of the editing events and acts on thousands ...
Allegra Mboukou, Vinod Rajendra, Serafina Messmer, Therese C. Mandl, Marjorie Catala, Carine Tisné, Michael F. Jantsch, Pierre Barraud   +7 more
doaj   +1 more source

ADAR1 p150 prevents HSV-1 from triggering PKR/eIF2α-mediated translational arrest and is required for efficient viral replication.

PLoS Pathogens
Adenosine deaminase acting on dsRNA 1 (ADAR1) catalyzes the deamination of adenosines to inosines in double-stranded RNAs (dsRNA) and regulates innate immunity by preventing the hyperactivation of cytosolic dsRNA sensors such as MDA5, PKR or ZBP1.
Adwait Parchure, Mia Cesarec, Antonija Braut, Robert Kolman, Vlatka Ivanišević, Marina Čunko, Slađana Bursać, Richard de Reuver, Antonija J Begonja, Umberto Rosani, Siniša Volarević, Jonathan Maelfait, Igor Jurak   +12 more
doaj   +1 more source

ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway [PDF]

Ying Wang, Jiang Chang, Fa Wang, Lianying Lai, ShiXu Yang, Yueying Fu, Xingtian Ma, Chuan Yun   +7 more
openalex   +1 more source

Restricting retrotransposons: ADAR1 is another guardian of the human genome [PDF]

, 2017
Elisa Orecchini, Loredana Frassinelli, Alessandro Michienzi   +2 more
openalex   +1 more source

Structural and mechanistic basis of ADAR1-mediated RNA editing and immune regulation

Cell Insight
Adenosine deaminase acting on RNA 1 (ADAR1) is a central regulator of innate immunity. By binding to and catalyzing adenosine-to-inosine deamination within double-stranded RNAs, ADAR1 mitigates the immunogenicity of self-derived RNAs and preserves ...
Xiangyu Deng, Mariam Elsharkawy, Yang Gao   +2 more
doaj   +1 more source

MOESM1 of ADAR1-mediated RNA-editing of 3′UTRs in breast cancer

, 2018
Eduardo A. Sagredo, Alejandro Blanco, Alfredo Sagredo, Paola Pérez, Gonzalo Sepúlveda-Hermosilla, Fernanda Morales, Bettina Müller, Ricardo A. Verdugo, Katherine Marcelain, Olivier Harismendy, Ricardo Armisén   +10 more
openalex   +1 more source

RNA editing regulates host immune response and T cell homeostasis in SARS-CoV-2 infection.

PLoS ONE
Adenosine to inosine (A-to-I) RNA editing by ADAR1 has been implicated in maintaining self-tolerance, preventing autoimmunity, and mediating antiviral immunity.
Molly Huang, Adam Mark, Jessica Pham, Karina Vera, Amanda M Saravia-Butler, Afshin Beheshti, Qingfei Jiang, Kathleen M Fisch   +7 more
doaj   +1 more source