Results 131 to 140 of about 7,998 (203)

Improving the Segmentation of Anatomical Structures in Chest Radiographs using U-Net with an ImageNet Pre-trained Encoder

, 2018
Accurate segmentation of anatomical structures in chest radiographs is essential for many computer-aided diagnosis tasks. In this paper we investigate the latest fully-convolutional architectures for the task of multi-class segmentation of the lungs ...
AA Novikov, B Ginneken Van, H Greenspan, J Shiraishi, LC Chen, O Ronneberger, S Hwang, SSM Salehi, W Yang   +8 more
core   +1 more source

ADAR1, a promising “protecting” biomarker in oral squamous cell carcinoma [PDF]

, 2019
Campisi, Giuseppina, CAPONIO, VITO CARLO ALBERTO, Dioguardi, Mario, Lo Muzio, Lorenzo, Mascitti, Marco, Santarelli, Andrea   +5 more
core   +1 more source

High-speed atomic force microscopy and 3D modeling reveal the structural dynamics of ADAR1 complexes

Nature Communications
Targeting abnormal dysregulation of adenosine-to-inosine deamination by ADAR enzymes offers a promising therapeutic strategy in cancer research. However, the development of effective inhibitors is impeded by the incomplete structural information on ADAR1
Madhu Biyani, Yasuhiro Isogai, Kirti Sharma, Shoei Maeda, Hinako Akashi, Yui Sugai, Masataka Nakano, Noriyuki Kodera, Manish Biyani, Miki Nakajima   +9 more
doaj   +1 more source

ADAR1 p150 prevents HSV-1 from triggering PKR/eIF2α-mediated translational arrest and is required for efficient viral replication.

PLoS Pathogens
Adenosine deaminase acting on dsRNA 1 (ADAR1) catalyzes the deamination of adenosines to inosines in double-stranded RNAs (dsRNA) and regulates innate immunity by preventing the hyperactivation of cytosolic dsRNA sensors such as MDA5, PKR or ZBP1.
Adwait Parchure, Mia Cesarec, Antonija Braut, Robert Kolman, Vlatka Ivanišević, Marina Čunko, Slađana Bursać, Richard de Reuver, Antonija J Begonja, Umberto Rosani, Siniša Volarević, Jonathan Maelfait, Igor Jurak   +12 more
doaj   +1 more source

Different forms of the double helix: architecture and function [PDF]

, 2004
The DNA double helix was discovered 50 years ago. This motif was found in several other places, most notably in RNA molecules. It is also found in DNA-RNA hybrids as well as transfer RNA molecules where double helical segments combine to form a more ...
Rich, Alexander
core  

RNA editing regulates host immune response and T cell homeostasis in SARS-CoV-2 infection.

PLoS ONE
Adenosine to inosine (A-to-I) RNA editing by ADAR1 has been implicated in maintaining self-tolerance, preventing autoimmunity, and mediating antiviral immunity.
Molly Huang, Adam Mark, Jessica Pham, Karina Vera, Amanda M Saravia-Butler, Afshin Beheshti, Qingfei Jiang, Kathleen M Fisch   +7 more
doaj   +1 more source

ADAR1: a mast regulator of aging and immunity

Signal Transduction and Targeted Therapy, 2023
Yigan Zhang, Jinyue Zhang, Yuanchao Xue
openaire   +3 more sources

The anti-apoptotic function of ADAR1 [PDF]

Nature Reviews Molecular Cell Biology, 2017
openaire   +1 more source

ADARs have effects beyond RNA editing [PDF]

, 2009
Heale, Bret S E, Keegan, Liam P, O'Connell, Mary A   +2 more
core   +1 more source

Adenosine-to-Inosine (A-to-I) RNA Editing by ADAR1 to Control RNA Sensing in Cardiovascular Disease. [PDF]

Arterioscler Thromb Vasc Biol
Weldy CS, Li JB, Quertermous T.
europepmc   +1 more source