Results 21 to 30 of about 7,998 (203)
SUMO-1 Modification Alters ADAR1 Editing Activity [PDF]
Molecular Biology of the Cell, 2005 We identify ADAR1, an RNA-editing enzyme with transient nucleolar localization, as a novel substrate for sumoylation. We show that ADAR1 colocalizes with SUMO-1 in a subnucleolar region that is distinct from the fibrillar center, the dense fibrillar component, and the granular component.
Desterro, Joana +5 more
openaire +3 more sources
Cell Reports, 2021 Summary: Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS). ADAR1 converts adenosines into inosines within dsRNA. This process called A-to-I
Richard de Reuver +11 more
doaj +1 more source
ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity [PDF]
Frontiers in Immunology, 2019 Specialized receptors that recognize molecular patterns such as double stranded RNA duplexes-indicative of viral replication-are potent triggers of the innate immune system. Although their activation is beneficial during viral infection, RNA transcribed from endogenous mobile genetic elements may also act as ligands potentially causing autoimmunity ...
Lamers, Mart +2 more
openaire +3 more sources
ADAR1 Editing and its Role in Cancer [PDF]
Genes, 2018 It is well established that somatic mutations and escape of immune disruption are two essential factors in cancer initiation and progression. With an increasing number of second-generation sequencing data, transcriptomic modifications, so called RNA mutations, are emerging as significant forces that drive the transition from normal cell to malignant ...
Li-Di Xu, Marie Öhman
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Genome Biology, 2017 Background Adenosine-to-inosine (A-to-I) editing of dsRNA by ADAR proteins is a pervasive epitranscriptome feature. Tens of thousands of A-to-I editing events are defined in the mouse, yet the functional impact of most is unknown. Editing causing protein
Jacki E. Heraud-Farlow +10 more
doaj +1 more source
ADAR1 is a prognostic biomarker and is correlated with immune infiltration in lung adenocarcinoma
Cancer Medicine, 2023 Background Lung adenocarcinoma (LUAD) is a common subtype of non‐small cell lung cancer with high morbidity and mortality rates and is usually detected at advanced stages because of the early onset of metastasis. Adenosine deaminase RNA‐specific 1 (ADAR1)
Wendi Yang +7 more
doaj +1 more source
DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]
, 2017 Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A +2 more
core +1 more source
RNA editing by ADAR1 marks dsRNA as “self” [PDF]
Cell Research, 2015 A paper recently published in Science reports that adenosine deaminase acting on RNA 1-dependent adenosine-to-inosine editing marks endogenous double strand RNA as self and prevents their immune recognition by cytosolic RNA sensor MDA5.
Zhou, Yu, Taoyong, Chen, Xuetao, Cao
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ADAR1-mediated RNA editing promotes B cell lymphomagenesis
iScience, 2023 Diffuse large B cell lymphoma (DLBCL) is one of the most common types of aggressive lymphoid malignancies. Here, we explore the contribution of RNA editing to DLBCL pathogenesis. We observed that DNA mutations and RNA editing events are often mutually exclusive, suggesting that tumors can modulate pathway outcomes by altering sequences at either the ...
Pecori, Riccardo +28 more
openaire +4 more sources
Journal of Experimental & Clinical Cancer Research, 2019 Background Adenosine deaminases acting on RNA (ADARs) are involved in adenosine-to-inosine (A-to-I) editing and implicated in tumorigenesis and prognosis.
Xue Liu +9 more
doaj +1 more source